Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model

NeuroToxicology

Volumn 44, Issue , 2014, Pages 250-262

  Sarkar, Sumit ^a   Chigurupati, Srinivasulu ^a   Raymick, James ^b   Mann, Dushyant ^c   Bowyer, John F ^a   Schmitt, Tom ^a   Beger, Richard D ^a   Hanig, Joseph P ^d   Schmued, Larry C ^a   Paule, Merle G ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b Toxicology Pathology Associates   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Endothelial cells; FT gel; Parkinson's disease; Trehalose; Tyrosine hydroxylase

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE TRANSPORTER; GLUCOSE TRANSPORTER; OCCLUDIN; PROTEIN ZO1; TREHALOSE; TYROSINE 3 MONOOXYGENASE; CHAPERONE; GLIAL FIBRILLARY ASTROCYTIC PROTEIN, MOUSE; GLUCOSE TRANSPORTER 1; NERVE PROTEIN; NEUROPROTECTIVE AGENT; SLC2A1 PROTEIN, MOUSE; TJP1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTIC HYPERTROPHY; CAUDATE PUTAMEN; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; ENVIRONMENTAL STRESS; HYPERTROPHY; IMMUNOREACTIVITY; IN VIVO STUDY; MALE; MESENCEPHALON; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN STABILITY; PUTAMEN; SUBSTANTIA NIGRA PARS COMPACTA; ANIMAL; C57BL MOUSE; CHEMISTRY; CORPUS STRIATUM; DISEASE MODEL; DRUG EFFECTS; ENCEPHALITIS; METABOLISM; PARKINSONIAN DISORDERS; VASCULARIZATION;

ANIMALS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; ENCEPHALITIS; GLUCOSE TRANSPORTER TYPE 1; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; MOLECULAR CHAPERONES; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; PARKINSONIAN DISORDERS; TREHALOSE; TYROSINE 3-MONOOXYGENASE; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84908334942     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2014.07.006     Document Type: Article

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