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Volumn 92, Issue 2, 2014, Pages 71-82

Risk of arterial thromboembolic events with vascular endothelial growth factor receptor tyrosine kinase inhibitors: An up-to-date meta-analysis

Author keywords

Angiogenesis inhibitors; Arterial thromboembolic events; Meta analysis; VEGFR TKIs

Indexed keywords

AXITINIB; BRIVANIB; CEDIRANIB; PAZOPANIB; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; VANDETANIB; PROTEIN KINASE INHIBITOR; VASCULOTROPIN RECEPTOR;

EID: 84908325508     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2014.04.004     Document Type: Review
Times cited : (62)

References (65)
  • 1
    • 0015311426 scopus 로고
    • Anti-angiogenesis: new concept for therapy of solid tumors
    • Folkman J. Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg 1972, 175:409-416.
    • (1972) Ann Surg , vol.175 , pp. 409-416
    • Folkman, J.1
  • 2
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin D.J., Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005, 23:1011-1027.
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 3
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial
    • Demetri G.D., van Oosterom A.T., Garrett C.R., Blackstein M.E., Shah M.H., Verweij J., et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 2006, 368:1329-1338.
    • (2006) Lancet , vol.368 , pp. 1329-1338
    • Demetri, G.D.1    van Oosterom, A.T.2    Garrett, C.R.3    Blackstein, M.E.4    Shah, M.H.5    Verweij, J.6
  • 5
    • 49149114782 scopus 로고    scopus 로고
    • Activity of sunitinib in patients with advanced neuroendocrine tumors
    • Kulke M.H., Lenz H.J., Meropol N.J., Posey J., Ryan D.P., Picus J., et al. Activity of sunitinib in patients with advanced neuroendocrine tumors. J Clin Oncol 2008, 26:3403-3410.
    • (2008) J Clin Oncol , vol.26 , pp. 3403-3410
    • Kulke, M.H.1    Lenz, H.J.2    Meropol, N.J.3    Posey, J.4    Ryan, D.P.5    Picus, J.6
  • 8
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial
    • Sternberg C.N., Davis I.D., Mardiak J., Szczylik C., Lee E., Wagstaff J., et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 2010, 28:1061-1068.
    • (2010) J Clin Oncol , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3    Szczylik, C.4    Lee, E.5    Wagstaff, J.6
  • 9
    • 84861098484 scopus 로고    scopus 로고
    • Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial
    • van der Graaf W.T., Blay J.Y., Chawla S.P., Kim D.W., Bui-Nguyen B., Casali P.G., et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2012, 379:1879-1886.
    • (2012) Lancet , vol.379 , pp. 1879-1886
    • van der Graaf, W.T.1    Blay, J.Y.2    Chawla, S.P.3    Kim, D.W.4    Bui-Nguyen, B.5    Casali, P.G.6
  • 10
    • 84655175698 scopus 로고    scopus 로고
    • Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial
    • Wells SA.Jr., Robinson B.G., Gagel R.F., Dralle H., Fagin J.A., Santoro M., et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J Clin Oncol 2012, 30:134-141.
    • (2012) J Clin Oncol , vol.30 , pp. 134-141
    • Wells, S.1    Robinson, B.G.2    Gagel, R.F.3    Dralle, H.4    Fagin, J.A.5    Santoro, M.6
  • 11
    • 84876974877 scopus 로고    scopus 로고
    • Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial
    • Motzer R.J., Escudier B., Tomczak P., Hutson T.E., Michaelson M.D., Negrier S., et al. Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol 2013, 14:552-562.
    • (2013) Lancet Oncol , vol.14 , pp. 552-562
    • Motzer, R.J.1    Escudier, B.2    Tomczak, P.3    Hutson, T.E.4    Michaelson, M.D.5    Negrier, S.6
  • 12
    • 82755183572 scopus 로고    scopus 로고
    • Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial
    • Rini B.I., Escudier B., Tomczak P., Kaprin A., Szczylik C., Hutson T.E., et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 2011, 378:1931-1939.
    • (2011) Lancet , vol.378 , pp. 1931-1939
    • Rini, B.I.1    Escudier, B.2    Tomczak, P.3    Kaprin, A.4    Szczylik, C.5    Hutson, T.E.6
  • 13
    • 84871911684 scopus 로고    scopus 로고
    • FDA approves regorafenib (Stivarga) for metastatic colorectal cancer
    • FDA approves regorafenib (Stivarga) for metastatic colorectal cancer. Oncology (Williston Park) 2012, 26:896.
    • (2012) Oncology (Williston Park) , vol.26 , pp. 896
  • 14
    • 84868667483 scopus 로고    scopus 로고
    • Incidence and risk of hypertension with vandetanib in cancer patients: a systematic review and meta-analysis of clinical trials
    • Qi W.X., Shen Z., Lin F., Sun Y.J., Min D.L., Tang L.N., et al. Incidence and risk of hypertension with vandetanib in cancer patients: a systematic review and meta-analysis of clinical trials. Br J Clin Pharmacol 2013, 75:919-930.
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 919-930
    • Qi, W.X.1    Shen, Z.2    Lin, F.3    Sun, Y.J.4    Min, D.L.5    Tang, L.N.6
  • 15
    • 84874117127 scopus 로고    scopus 로고
    • Incidence and risk of hypertension with pazopanib in patients with cancer: a meta-analysis
    • Qi W.X., Lin F., Sun Y.J., Tang L.N., He A.N., Yao Y., et al. Incidence and risk of hypertension with pazopanib in patients with cancer: a meta-analysis. Cancer Chemother Pharmacol 2013, 71:431-439.
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 431-439
    • Qi, W.X.1    Lin, F.2    Sun, Y.J.3    Tang, L.N.4    He, A.N.5    Yao, Y.6
  • 16
    • 84882578238 scopus 로고    scopus 로고
    • Incidence and risk of hypertension with a novel multi-targeted kinase inhibitor axitinib in cancer patients: a systematic review and meta-analysis
    • Qi W.X., He A.N., Shen Z., Yao Y. Incidence and risk of hypertension with a novel multi-targeted kinase inhibitor axitinib in cancer patients: a systematic review and meta-analysis. Br J Clin Pharmacol 2013, 76:348-357.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 348-357
    • Qi, W.X.1    He, A.N.2    Shen, Z.3    Yao, Y.4
  • 17
    • 38549085315 scopus 로고    scopus 로고
    • Incidence and risk of hypertension with sorafenib in patients with cancer: a systematic review and meta-analysis
    • Wu S., Chen J.J., Kudelka A., Lu J., Zhu X. Incidence and risk of hypertension with sorafenib in patients with cancer: a systematic review and meta-analysis. Lancet Oncol 2008, 9:117-123.
    • (2008) Lancet Oncol , vol.9 , pp. 117-123
    • Wu, S.1    Chen, J.J.2    Kudelka, A.3    Lu, J.4    Zhu, X.5
  • 18
    • 77955523015 scopus 로고    scopus 로고
    • Incidence and risk of significantly raised blood pressure in cancer patients treated with bevacizumab: an updated meta-analysis
    • An M.M., Zou Z., Shen H., Liu P., Chen M.L., Cao Y.B., et al. Incidence and risk of significantly raised blood pressure in cancer patients treated with bevacizumab: an updated meta-analysis. Eur J Clin Pharmacol 2010, 66:813-821.
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 813-821
    • An, M.M.1    Zou, Z.2    Shen, H.3    Liu, P.4    Chen, M.L.5    Cao, Y.B.6
  • 19
    • 58149098429 scopus 로고    scopus 로고
    • Risk of hypertension and renal dysfunction with an angiogenesis inhibitor sunitinib: systematic review and meta-analysis
    • Zhu X., Stergiopoulos K., Wu S. Risk of hypertension and renal dysfunction with an angiogenesis inhibitor sunitinib: systematic review and meta-analysis. Acta Oncol 2009, 48:9-17.
    • (2009) Acta Oncol , vol.48 , pp. 9-17
    • Zhu, X.1    Stergiopoulos, K.2    Wu, S.3
  • 20
    • 84898832060 scopus 로고    scopus 로고
    • Risk of hypertension in cancer patients treated with aflibercept: a systematic review and meta-analysis
    • Qi W.X., Shen Z., Tang L.N., Yao Y. Risk of hypertension in cancer patients treated with aflibercept: a systematic review and meta-analysis. Clin Drug Investig 2014, 34:231-240.
    • (2014) Clin Drug Investig , vol.34 , pp. 231-240
    • Qi, W.X.1    Shen, Z.2    Tang, L.N.3    Yao, Y.4
  • 21
    • 84866728723 scopus 로고    scopus 로고
    • The risk of hand foot skin reaction to pazopanib, a novel multikinase inhibitor: a systematic review of literature and meta-analysis
    • Balagula Y., Wu S., Su X., Feldman D.R., Lacouture M.E. The risk of hand foot skin reaction to pazopanib, a novel multikinase inhibitor: a systematic review of literature and meta-analysis. Invest New Drugs 2011.
    • (2011) Invest New Drugs
    • Balagula, Y.1    Wu, S.2    Su, X.3    Feldman, D.R.4    Lacouture, M.E.5
  • 22
    • 84879089369 scopus 로고    scopus 로고
    • The risk of hand-foot skin reaction to axitinib, a novel VEGF inhibitor: a systematic review of literature and meta-analysis
    • Fischer A., Wu S., Ho A.L., Lacouture M.E. The risk of hand-foot skin reaction to axitinib, a novel VEGF inhibitor: a systematic review of literature and meta-analysis. Invest New Drugs 2013.
    • (2013) Invest New Drugs
    • Fischer, A.1    Wu, S.2    Ho, A.L.3    Lacouture, M.E.4
  • 23
    • 84880916933 scopus 로고    scopus 로고
    • Risk of hand-foot skin reaction with the novel multikinase inhibitor regorafenib: a meta-analysis
    • Belum V.R., Wu S., Lacouture M.E. Risk of hand-foot skin reaction with the novel multikinase inhibitor regorafenib: a meta-analysis. Invest New Drugs 2013.
    • (2013) Invest New Drugs
    • Belum, V.R.1    Wu, S.2    Lacouture, M.E.3
  • 24
    • 84866736079 scopus 로고    scopus 로고
    • The risk of hand foot skin reaction to pazopanib, a novel multikinase inhibitor: a systematic review of literature and meta-analysis
    • Balagula Y., Wu S., Su X., Feldman D.R., Lacouture M.E. The risk of hand foot skin reaction to pazopanib, a novel multikinase inhibitor: a systematic review of literature and meta-analysis. Invest New Drugs 2012, 30:1773-1781.
    • (2012) Invest New Drugs , vol.30 , pp. 1773-1781
    • Balagula, Y.1    Wu, S.2    Su, X.3    Feldman, D.R.4    Lacouture, M.E.5
  • 25
    • 65249140606 scopus 로고    scopus 로고
    • Risk of hand-foot skin reaction with the multitargeted kinase inhibitor sunitinib in patients with renal cell and non-renal cell carcinoma: a meta-analysis
    • Chu D., Lacouture M.E., Weiner E., Wu S. Risk of hand-foot skin reaction with the multitargeted kinase inhibitor sunitinib in patients with renal cell and non-renal cell carcinoma: a meta-analysis. Clin Genitourin Cancer 2009, 7:11-19.
    • (2009) Clin Genitourin Cancer , vol.7 , pp. 11-19
    • Chu, D.1    Lacouture, M.E.2    Weiner, E.3    Wu, S.4
  • 26
    • 84888793629 scopus 로고    scopus 로고
    • Incidence and risk of hemorrhagic events with vascular endothelial growth factor receptor tyrosine-kinase inhibitors: an up-to-date meta-analysis of 27 randomized controlled trials
    • Qi W.X., Tang L.N., Sun Y.J., He A.N., Lin F., Shen Z., et al. Incidence and risk of hemorrhagic events with vascular endothelial growth factor receptor tyrosine-kinase inhibitors: an up-to-date meta-analysis of 27 randomized controlled trials. Ann Oncol 2013, 24:2943-2952.
    • (2013) Ann Oncol , vol.24 , pp. 2943-2952
    • Qi, W.X.1    Tang, L.N.2    Sun, Y.J.3    He, A.N.4    Lin, F.5    Shen, Z.6
  • 27
    • 78049382933 scopus 로고    scopus 로고
    • Increased risk of serious hemorrhage with bevacizumab in cancer patients: a meta-analysis
    • Hapani S., Sher A., Chu D., Wu S. Increased risk of serious hemorrhage with bevacizumab in cancer patients: a meta-analysis. Oncology 2010, 79:27-38.
    • (2010) Oncology , vol.79 , pp. 27-38
    • Hapani, S.1    Sher, A.2    Chu, D.3    Wu, S.4
  • 28
    • 70349393610 scopus 로고    scopus 로고
    • Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials
    • Je Y., Schutz F.A., Choueiri T.K. Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials. Lancet Oncol 2009, 10:967-974.
    • (2009) Lancet Oncol , vol.10 , pp. 967-974
    • Je, Y.1    Schutz, F.A.2    Choueiri, T.K.3
  • 29
    • 84893805528 scopus 로고    scopus 로고
    • Risk of gastrointestinal perforation in cancer patients treated with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a systematic review and meta-analysis
    • Qi W.X., Sun Y.J., Tang L.N., Shen Z., Yao Y. Risk of gastrointestinal perforation in cancer patients treated with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a systematic review and meta-analysis. Crit Rev Oncol Hematol 2014, 89:394-403.
    • (2014) Crit Rev Oncol Hematol , vol.89 , pp. 394-403
    • Qi, W.X.1    Sun, Y.J.2    Tang, L.N.3    Shen, Z.4    Yao, Y.5
  • 30
    • 66149121478 scopus 로고    scopus 로고
    • Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis
    • Hapani S., Chu D., Wu S. Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis. Lancet Oncol 2009, 10:559-568.
    • (2009) Lancet Oncol , vol.10 , pp. 559-568
    • Hapani, S.1    Chu, D.2    Wu, S.3
  • 31
    • 77951269420 scopus 로고    scopus 로고
    • Risk of cardiac ischemia and arterial thromboembolic events with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis of randomized controlled trials
    • Ranpura V., Hapani S., Chuang J., Wu S. Risk of cardiac ischemia and arterial thromboembolic events with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis of randomized controlled trials. Acta Oncol 2010, 49:287-297.
    • (2010) Acta Oncol , vol.49 , pp. 287-297
    • Ranpura, V.1    Hapani, S.2    Chuang, J.3    Wu, S.4
  • 32
    • 34548141828 scopus 로고    scopus 로고
    • Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab
    • Scappaticci F.A., Skillings J.R., Holden S.N., Gerber H.P., Miller K., Kabbinavar F., et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst 2007, 99:1232-1239.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1232-1239
    • Scappaticci, F.A.1    Skillings, J.R.2    Holden, S.N.3    Gerber, H.P.4    Miller, K.5    Kabbinavar, F.6
  • 33
    • 79957790694 scopus 로고    scopus 로고
    • Bevacizumab increases the risk of arterial ischemia: a large study in cancer patients with a focus on different subgroup outcomes
    • Schutz F.A., Je Y., Azzi G.R., Nguyen P.L., Choueiri T.K. Bevacizumab increases the risk of arterial ischemia: a large study in cancer patients with a focus on different subgroup outcomes. Ann Oncol 2011, 22:1404-1412.
    • (2011) Ann Oncol , vol.22 , pp. 1404-1412
    • Schutz, F.A.1    Je, Y.2    Azzi, G.R.3    Nguyen, P.L.4    Choueiri, T.K.5
  • 34
    • 77952310126 scopus 로고    scopus 로고
    • Risk of arterial thromboembolic events with sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials
    • Choueiri T.K., Schutz F.A., Je Y., Rosenberg J.E., Bellmunt J. Risk of arterial thromboembolic events with sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials. J Clin Oncol 2010, 28:2280-2285.
    • (2010) J Clin Oncol , vol.28 , pp. 2280-2285
    • Choueiri, T.K.1    Schutz, F.A.2    Je, Y.3    Rosenberg, J.E.4    Bellmunt, J.5
  • 36
    • 84885587718 scopus 로고    scopus 로고
    • Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study
    • Llovet J.M., Decaens T., Raoul J.L., Boucher E., Kudo M., Chang C., et al. Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study. J Clin Oncol 2013.
    • (2013) J Clin Oncol
    • Llovet, J.M.1    Decaens, T.2    Raoul, J.L.3    Boucher, E.4    Kudo, M.5    Chang, C.6
  • 37
    • 84884821257 scopus 로고    scopus 로고
    • Cediranib in combination with fulvestrant in hormone-sensitive metastatic breast cancer: a randomized phase II study
    • Hyams D.M., Chan A., de Oliveira C., Snyder R., Vinholes J., Audeh M.W., et al. Cediranib in combination with fulvestrant in hormone-sensitive metastatic breast cancer: a randomized phase II study. Invest New Drugs 2013, 31:1345-1354.
    • (2013) Invest New Drugs , vol.31 , pp. 1345-1354
    • Hyams, D.M.1    Chan, A.2    de Oliveira, C.3    Snyder, R.4    Vinholes, J.5    Audeh, M.W.6
  • 38
    • 84888132613 scopus 로고    scopus 로고
    • Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial
    • Hutson T.E., Lesovoy V., Al-Shukri S., Stus V.P., Lipatov O.N., Bair A.H., et al. Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial. Lancet Oncol 2013, 14:1287-1294.
    • (2013) Lancet Oncol , vol.14 , pp. 1287-1294
    • Hutson, T.E.1    Lesovoy, V.2    Al-Shukri, S.3    Stus, V.P.4    Lipatov, O.N.5    Bair, A.H.6
  • 39
    • 79952748468 scopus 로고    scopus 로고
    • Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer
    • Natale R.B., Thongprasert S., Greco F.A., Thomas M., Tsai C.M., Sunpaweravong P., et al. Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol 2011, 29:1059-1066.
    • (2011) J Clin Oncol , vol.29 , pp. 1059-1066
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3    Thomas, M.4    Tsai, C.M.5    Sunpaweravong, P.6
  • 40
    • 84925548115 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • Moher D., Liberati A., Tetzlaff J., Altman D.G., Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009, 62:1006-1012.
    • (2009) J Clin Epidemiol , vol.62 , pp. 1006-1012
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4    Group, P.5
  • 41
    • 84908326345 scopus 로고    scopus 로고
    • Cancer Therapy Evaluation Program. CTC v 2.0 and common terminology criteria for adverse events criteria V3.0 (CTCAE) [assessed 27.01 13]
    • NCI, Cancer Therapy Evaluation Program. CTC v 2.0 and common terminology criteria for adverse events criteria V3.0 (CTCAE), http://ctepcancergov/protocolDevelopment/electronic_applications/ctchtm> [assessed 27.01 13].
  • 42
    • 2342661718 scopus 로고    scopus 로고
    • What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data
    • Sweeting M.J., Sutton A.J., Lambert P.C. What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data. Stat Med 2004, 23:1351-1375.
    • (2004) Stat Med , vol.23 , pp. 1351-1375
    • Sweeting, M.J.1    Sutton, A.J.2    Lambert, P.C.3
  • 43
    • 12744274510 scopus 로고    scopus 로고
    • Heterogeneity testing in meta-analysis of genome searches
    • Zintzaras E., Ioannidis J.P. Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol 2005, 28:123-137.
    • (2005) Genet Epidemiol , vol.28 , pp. 123-137
    • Zintzaras, E.1    Ioannidis, J.P.2
  • 44
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • Escudier B., Eisen T., Stadler W.M., Szczylik C., Oudard S., Staehler M., et al. Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009, 27:3312-3318.
    • (2009) J Clin Oncol , vol.27 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3    Szczylik, C.4    Oudard, S.5    Staehler, M.6
  • 45
    • 84890274647 scopus 로고    scopus 로고
    • Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study
    • Johnson P.J., Qin S., Park J.W., Poon R.T., Raoul J.L., Philip P.A., et al. Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study. J Clin Oncol 2013, 31:3517-3524.
    • (2013) J Clin Oncol , vol.31 , pp. 3517-3524
    • Johnson, P.J.1    Qin, S.2    Park, J.W.3    Poon, R.T.4    Raoul, J.L.5    Philip, P.A.6
  • 46
    • 78349298645 scopus 로고    scopus 로고
    • Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial
    • Abou-Alfa G.K., Johnson P., Knox J.J., Capanu M., Davidenko I., Lacava J., et al. Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA 2010, 304:2154-2160.
    • (2010) JAMA , vol.304 , pp. 2154-2160
    • Abou-Alfa, G.K.1    Johnson, P.2    Knox, J.J.3    Capanu, M.4    Davidenko, I.5    Lacava, J.6
  • 47
    • 84868107516 scopus 로고    scopus 로고
    • BAYPAN study: a double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer
    • Goncalves A., Gilabert M., Francois E., Dahan L., Perrier H., Lamy R., et al. BAYPAN study: a double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer. Ann Oncol 2012, 23:2799-2805.
    • (2012) Ann Oncol , vol.23 , pp. 2799-2805
    • Goncalves, A.1    Gilabert, M.2    Francois, E.3    Dahan, L.4    Perrier, H.5    Lamy, R.6
  • 48
    • 79952036599 scopus 로고    scopus 로고
    • Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study
    • Kindler H.L., Ioka T., Richel D.J., Bennouna J., Letourneau R., Okusaka T., et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Lancet Oncol 2011, 12:256-262.
    • (2011) Lancet Oncol , vol.12 , pp. 256-262
    • Kindler, H.L.1    Ioka, T.2    Richel, D.J.3    Bennouna, J.4    Letourneau, R.5    Okusaka, T.6
  • 49
    • 45449090215 scopus 로고    scopus 로고
    • Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study
    • Spano J.P., Chodkiewicz C., Maurel J., Wong R., Wasan H., Barone C., et al. Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study. Lancet 2008, 371:2101-2108.
    • (2008) Lancet , vol.371 , pp. 2101-2108
    • Spano, J.P.1    Chodkiewicz, C.2    Maurel, J.3    Wong, R.4    Wasan, H.5    Barone, C.6
  • 50
    • 84883360843 scopus 로고    scopus 로고
    • A randomized, double-blind, phase II study of erlotinib with or without sunitinib for the second-line treatment of metastatic non-small-cell lung cancer (NSCLC)
    • Groen H.J., Socinski M.A., Grossi F., Juhasz E., Gridelli C., Baas P., et al. A randomized, double-blind, phase II study of erlotinib with or without sunitinib for the second-line treatment of metastatic non-small-cell lung cancer (NSCLC). Ann Oncol 2013.
    • (2013) Ann Oncol
    • Groen, H.J.1    Socinski, M.A.2    Grossi, F.3    Juhasz, E.4    Gridelli, C.5    Baas, P.6
  • 51
    • 77951639655 scopus 로고    scopus 로고
    • Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
    • Scagliotti G., Novello S., von Pawel J., Reck M., Pereira J.R., Thomas M., et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. J Clin Oncol 2010, 28:1835-1842.
    • (2010) J Clin Oncol , vol.28 , pp. 1835-1842
    • Scagliotti, G.1    Novello, S.2    von Pawel, J.3    Reck, M.4    Pereira, J.R.5    Thomas, M.6
  • 52
    • 84872110165 scopus 로고    scopus 로고
    • A double-blind, randomised, placebo-controlled, phase 2b study evaluating sorafenib in combination with paclitaxel as a first-line therapy in patients with HER2-negative advanced breast cancer
    • Gradishar W.J., Kaklamani V., Sahoo T.P., Lokanatha D., Raina V., Bondarde S., et al. A double-blind, randomised, placebo-controlled, phase 2b study evaluating sorafenib in combination with paclitaxel as a first-line therapy in patients with HER2-negative advanced breast cancer. Eur J Cancer 2013, 49:312-322.
    • (2013) Eur J Cancer , vol.49 , pp. 312-322
    • Gradishar, W.J.1    Kaklamani, V.2    Sahoo, T.P.3    Lokanatha, D.4    Raina, V.5    Bondarde, S.6
  • 53
    • 84886534519 scopus 로고    scopus 로고
    • Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial
    • Serve H., Krug U., Wagner R., Sauerland M.C., Heinecke A., Brunnberg U., et al. Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial. J Clin Oncol 2013, 31:3110-3118.
    • (2013) J Clin Oncol , vol.31 , pp. 3110-3118
    • Serve, H.1    Krug, U.2    Wagner, R.3    Sauerland, M.C.4    Heinecke, A.5    Brunnberg, U.6
  • 54
    • 84876089340 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: a randomized, phase III trial
    • Carrato A., Swieboda-Sadlej A., Staszewska-Skurczynska M., Lim R., Roman L., Shparyk Y., et al. Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: a randomized, phase III trial. J Clin Oncol 2013.
    • (2013) J Clin Oncol
    • Carrato, A.1    Swieboda-Sadlej, A.2    Staszewska-Skurczynska, M.3    Lim, R.4    Roman, L.5    Shparyk, Y.6
  • 56
    • 84870768153 scopus 로고    scopus 로고
    • Risk of venous thromboembolism in patients with cancer treated with cisplatin: a systematic review and meta-analysis
    • Seng S., Liu Z., Chiu S.K., Proverbs-Singh T., Sonpavde G., Choueiri T.K., et al. Risk of venous thromboembolism in patients with cancer treated with cisplatin: a systematic review and meta-analysis. J Clin Oncol 2012.
    • (2012) J Clin Oncol
    • Seng, S.1    Liu, Z.2    Chiu, S.K.3    Proverbs-Singh, T.4    Sonpavde, G.5    Choueiri, T.K.6
  • 57
    • 78049501837 scopus 로고    scopus 로고
    • Risk of arterial thrombosis not increased by sorafenib or sunitinib
    • author reply e20
    • Minor D.R. Risk of arterial thrombosis not increased by sorafenib or sunitinib. J Clin Oncol 2010, 28:e619. author reply e20.
    • (2010) J Clin Oncol , vol.28 , pp. e619
    • Minor, D.R.1
  • 58
    • 79955587689 scopus 로고    scopus 로고
    • Venous thromboembolic events with chemotherapy plus bevacizumab: a pooled analysis of patients in randomized phase II and III studies
    • Hurwitz H.I., Saltz L.B., Van Cutsem E., Cassidy J., Wiedemann J., Sirzen F., et al. Venous thromboembolic events with chemotherapy plus bevacizumab: a pooled analysis of patients in randomized phase II and III studies. J Clin Oncol 2011, 29:1757-1764.
    • (2011) J Clin Oncol , vol.29 , pp. 1757-1764
    • Hurwitz, H.I.1    Saltz, L.B.2    Van Cutsem, E.3    Cassidy, J.4    Wiedemann, J.5    Sirzen, F.6
  • 59
    • 56649123212 scopus 로고    scopus 로고
    • Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis
    • Nalluri S.R., Chu D., Keresztes R., Zhu X., Wu S. Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis. JAMA 2008, 300:2277-2285.
    • (2008) JAMA , vol.300 , pp. 2277-2285
    • Nalluri, S.R.1    Chu, D.2    Keresztes, R.3    Zhu, X.4    Wu, S.5
  • 60
    • 64249135367 scopus 로고    scopus 로고
    • Risk of venous thromboembolism with bevacizumab in cancer patients
    • author reply 5-6
    • Minor D.R. Risk of venous thromboembolism with bevacizumab in cancer patients. JAMA 2009, 301:1434. author reply 5-6.
    • (2009) JAMA , vol.301 , pp. 1434
    • Minor, D.R.1
  • 61
    • 84878602173 scopus 로고    scopus 로고
    • Venous thromboembolic events with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a systematic review and meta-analysis of randomized clinical trials
    • Sonpavde G., Je Y., Schutz F., Galsky M.D., Paluri R., Rosenberg J.E., et al. Venous thromboembolic events with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a systematic review and meta-analysis of randomized clinical trials. Crit Rev Oncol Hematol 2013, 87:80-89.
    • (2013) Crit Rev Oncol Hematol , vol.87 , pp. 80-89
    • Sonpavde, G.1    Je, Y.2    Schutz, F.3    Galsky, M.D.4    Paluri, R.5    Rosenberg, J.E.6
  • 62
    • 84876142760 scopus 로고    scopus 로고
    • Risk of venous thromboembolic events associated with VEGFR-TKIs: a systematic review and meta-analysis
    • Qi W.X., Min D.L., Shen Z., Sun Y.J., Lin F., Tang L.N., et al. Risk of venous thromboembolic events associated with VEGFR-TKIs: a systematic review and meta-analysis. Int J Cancer 2013, 132:2967-2974.
    • (2013) Int J Cancer , vol.132 , pp. 2967-2974
    • Qi, W.X.1    Min, D.L.2    Shen, Z.3    Sun, Y.J.4    Lin, F.5    Tang, L.N.6
  • 63
    • 80054686355 scopus 로고    scopus 로고
    • Chemotherapy-associated thromboembolic risk in cancer outpatients and effect of nadroparin thromboprophylaxis: results of a retrospective analysis of the PROTECHT study
    • Barni S., Labianca R., Agnelli G., Bonizzoni E., Verso M., Mandala M., et al. Chemotherapy-associated thromboembolic risk in cancer outpatients and effect of nadroparin thromboprophylaxis: results of a retrospective analysis of the PROTECHT study. J Transl Med 2011, 9:179.
    • (2011) J Transl Med , vol.9 , pp. 179
    • Barni, S.1    Labianca, R.2    Agnelli, G.3    Bonizzoni, E.4    Verso, M.5    Mandala, M.6
  • 64
    • 84864322826 scopus 로고    scopus 로고
    • Risk of venous and arterial thromboembolic events associated with anti-EGFR agents: a meta-analysis of randomized clinical trials
    • Petrelli F., Cabiddu M., Borgonovo K., Barni S. Risk of venous and arterial thromboembolic events associated with anti-EGFR agents: a meta-analysis of randomized clinical trials. Ann Oncol 2012, 23:1672-1679.
    • (2012) Ann Oncol , vol.23 , pp. 1672-1679
    • Petrelli, F.1    Cabiddu, M.2    Borgonovo, K.3    Barni, S.4
  • 65
    • 84863041902 scopus 로고    scopus 로고
    • Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors
    • Steingart R.M., Bakris G.L., Chen H.X., Chen M.H., Force T., Ivy S.P., et al. Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors. Am Heart J 2012, 163:156-163.
    • (2012) Am Heart J , vol.163 , pp. 156-163
    • Steingart, R.M.1    Bakris, G.L.2    Chen, H.X.3    Chen, M.H.4    Force, T.5    Ivy, S.P.6


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