The mycotoxin beauvericin induces apoptotic cell death in H4IIE hepatoma cells accompanied by an inhibition of NF-κB-activity and modulation of MAP-kinases

Toxicology Letters

Volumn 231, Issue 1, 2014, Pages 9-16

  Wätjen, Wim ^a,b   Debbab, Abdessamab ^b   Hohlfeld, Anke ^b   Chovolou, Yvonni ^b   Proksch, Peter ^b  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Apoptosis; Cytotoxicity; ERK; JNK; MAPK; Mycotoxin; NF B

Indexed keywords

BEAUVERICIN; CASPASE 3; CASPASE 7; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE; DEPSIPEPTIDE; MYCOTOXIN; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

ANGIOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CYTOTOXICITY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; GLIOMA CELL; HEPATOMA CELL; HUMAN; HUMAN CELL; IC50; MTT ASSAY; NONHUMAN; RAT; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; HCT116 CELL LINE; HEPG2 CELL LINE; ISOLATION AND PURIFICATION; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; NECROSIS; PATHOLOGY; PHOSPHORYLATION; TIME; TOXICITY;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL SURVIVAL; DEPSIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HCT116 CELLS; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASES; MYCOTOXINS; NECROSIS; NF-KAPPA B; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TIME FACTORS;

EID: 84908322855     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.08.021     Document Type: Article

References (26)

1. Ashour M., Edrada R., Ebel R., Wray V., Wätjen W., Padmakumar K., Müller W.E., Lin W.H., Proksch P. Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia. J. Nat. Prod. 2006, 69:1547-1553.
2. Chovolou Y., Ebada S.S., Wätjen W., Proksch P. Identification of angular naphthopyrones from the Philippine echinoderm Comanthus species as inhibitors of the NF-B signaling pathway. Eur. J. Pharmacol. 2011, 657:26-34.
3. Dombrink-Kurtzman M.A. Fumonisin and beauvericin induce apoptosis in turkey peripheral blood lymphocytes. Mycopathologia 2003, 156:357-364.
4. Dornetshuber R., Heffeter P., Kamyar M.R., Peterbauer T., Berger W., Lemmens-Gruber R. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Chem. Res. Toxicol. 2007, 20:465-473.
5. Dornetshuber R., Heffeter P., Lemmens-Gruber R., Elbling L., Marko D., Micksche M., Berger W. Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction. Mol. Nutr. Food Res. 2009, 53:1112.
6. Ferrer E., Juan-García A., Font G., Ruiz M.J. Reactive oxygen species induced by beauvericin, patulin and zearalenone in CHO-K1 cells. Toxicol. in Vitro 2009, 23:1504-1509.
7. Fukuda T., Arai M., Tomoda H., Omura S. New beauvericins potentiators of antifungal miconazole activity, produced by Beauveria sp. FKI-1366. II. Structure elucidation. J. Antibiot. 2004, 57:117-124.
8. Jestoi M. Emerging fusarium-mycotoxins fusaproliferin, beauvericin, enniatins, and moniliformin: a review. Crit. Rev. Food Sci. Nutr. 2008, 48:21-49.
9. Jow G.M., Chou C.J., Chen B.F., Tsai J.H. Beauvericin induces cytotoxic effects in human acute lymphoblastic leukemia cells through cytochrome c release caspase 3 activation: the causative role of calcium. Cancer Lett. 2004, 216:165-173.
10. Klarić M.S., Pepeljnjak S., Domijan A.M., Petrik J. Lipid peroxidation and glutathione levels in porcine kidney PK15 cells after individual and combined treatment with fumonisin B(1), beauvericin and ochratoxin A. Basic Clin. Pharmacol. Toxicol. 2007, 100:157-164.
11. Klarić M.S., Rumora L., Ljubanović D., Pepeljnjak S. Cytotoxicity and apoptosis induced by fumonisin B(1): beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment. Arch. Toxicol. 2008, 82:247-255.
12. Limper C., Wang Y., Ruhl S., Wang Z., Lou Y., Totzke F., Kubbutat M.H., Chovolou Y., Proksch P., Wätjen W. Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. J. Pharm. Pharmacol. 2013, 65:1393-1408.
13. Lin H.I., Lee Y.J., Chen B.F., Tsai M.C., Lu J.L., Chou C.J., Jow G.M. Involvement of Bcl-2 family: cytochrome c and caspase 3 in induction of apoptosis by beauvericin in human non-small cell lung cancer cells. Cancer Lett. 2005, 230:248-259.
14. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
15. Mallebrera B., Font G., Ruiz M.J. Disturbance of antioxidant capacity produced by beauvericin in CHO-K1 cells. Toxicol. Lett. 2014, 226:337-342.
16. Marin S., Ramos A.J., Cano-Sancho G., Sanchis V. Mycotoxins: occurrence toxicology, and exposure assessment. Food Chem. Toxicol. 2013, 60:218-237.
17. Michels G., Wätjen W., Weber N., Niering P., Chovolou Y., Kampkötter A., Proksch P., Kahl R. Resveratrol induces apoptotic cell death in rat H4IIE hepatoma cells but necrosis in C6 glioma cells. Toxicology 2006, 225:173-182.
18. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
19. Prosperini A., Juan-García A., Font G., Ruiz M.J. Beauvericin-induced cytotoxicity via ROS production and mitochondrial damage in Caco-2 cells. Toxicol. Lett. 2013, 222:204-211.
20. Que F.G., Gores G.J., LaRusso N.F. Development and initial application of an in vitro model of apoptosis in rodent cholangiocytes. Am. J. Physiol. 1997, 272(1 Pt 1):G106-G115.
21. Re R., Pellegrini N., Proteggente A., Pannala A., Yang M., Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol. Med. 1999, 26:1231-1237.
22. Santini A., Ritieni A., Fogliano V., Randazzo G., Mannina L., Logrieco A., Benedetti E. Structure and absolute stereochemistry of fusaproliferin, a toxic metabolite from Fusarium proliferatum. J. Nat. Prod. 1996, 59:109-112.
23. Wätjen W., Debbab A., Hohlfeld A., Chovolou Y., Kampkötter A., Edrada R.A., Ebel R., Hakiki A., Mosaddak M., Totzke F., Kubbutat M.H., Proksch P. Enniatins A1: B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol. Nutr. Food Res. 2009, 53:431-440.
24. Wang Q., Xu L. Beauvericin: a bioactive compound produced by fungi: a short review. Molecules 2012, 17:2367-2377.
25. Wu X.F., Xu R., Ouyang Z.J., Qian C., Shen Y., Wu X.D., Gu Y.H., Xu Q., Sun Y. Beauvericin ameliorates experimental colitis by inhibiting activated T cells via downregulation of the PI3K/Akt signaling pathway. PLoS One 2013, 8:e83013.
26. Zhan J., Burns A.M., Liu M.X., Faeth S.H., Gunatilaka A.A. Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum. J. Nat. Prod. 2007, 70:227-232.