A Gain-of-Function Mutation in Tnni2 Impeded Bone Development through Increasing Hif3a Expression in DA2B Mice

PLoS Genetics

Volumn 10, Issue 10, 2014, Pages

  Zhu, Xiaoquan ^a,b   Wang, Fengchao ^b   Zhao, Yanyang ^a   Yang, Peng ^b   Chen, Jun ^b   Sun, Hanzi ^b   Liu, Lei ^b   Li, Wenjun ^b   Pan, Lin ^c   Guo, Yanru ^c   Kou, Zhaohui ^b   Zhang, Yu ^b   Zhou, Cheng ^d   He, Jiang ^e   Zhang, Xue ^f   Li, Jianxin ^g   Han, Weitian ^g   Li, Jian ^a   Liu, Guanghui ^h   Gao, Shaorong ^b,i   Yang, Ze ^a   more..

^a BEIJING HOSPITAL   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^c CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^d BEIJING HOSPITAL   (China)

^e TULANE UNIVERSITY   (United States)

^f INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^g Key Laboratory of Reproductive Health   (China)

^h INSTITUTE OF BIOPHYSICS   (China)

ⁱ TONGJI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; TROPONIN I; TROPONIN I TYPE 2; UNCLASSIFIED DRUG; VASCULOTROPIN; CALCIUM; HIF3A PROTEIN, MOUSE; TNNI2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY SIZE; BONE DEFORMATION; BONE GROWTH; BONE PLATE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DISTAL ARTHROGRYPOSIS TYPE 2B; EMBRYO; ENCHONDRAL OSSIFICATION; FAST MUSCLE; GAIN OF FUNCTION MUTATION; GENE; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE FUNCTION; GENETIC DISORDER; HETEROZYGOSITY; HIF3A GENE; HOMOZYGOSITY; HUMAN; LIMB DEFORMITY; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; OSTEOBLAST; PATHOGENESIS; PHENOTYPE; PROMOTER REGION; PROTEIN BINDING; RADIUS; TNNI2 GENE; ULNA; VEGF GENE; ANIMAL; ARTHROGRYPOSIS; BIOSYNTHESIS; BONE DEVELOPMENT; GENE EXPRESSION REGULATION; GENE TARGETING; GENETICS; METABOLISM; MUSCLE CONTRACTION; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; SARCOMERE;

ANIMALS; ARTHROGRYPOSIS; BONE DEVELOPMENT; CALCIUM; GENE EXPRESSION REGULATION; GENE KNOCK-IN TECHNIQUES; HUMANS; MICE; MUSCLE CONTRACTION; MUTATION; SARCOMERES; TRANSCRIPTION FACTORS; TROPONIN I; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84908313431     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004589     Document Type: Article

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