Protective effects of perindopril on d-galactose and aluminum trichloride induced neurotoxicity via the apoptosis of mitochondria-mediated intrinsic pathway in the hippocampus of mice

Brain Research Bulletin

Volumn 109, Issue , 2014, Pages 46-53

  Yang, Weina ^a   Shi, Lili ^b   Chen, Lianji ^c   Zhang, Bingyi ^a   Ma, Kaige ^a   Liu, Yong ^a   Qian, Yihua ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b XI'AN MEDICAL UNIVERSITY   (China)

^c SHAANXI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Aluminum trichloride; Apoptosis; D Galactose; Hippocampus; Mouse; Perindopril

Indexed keywords

ALUMINUM; CASPASE 3; CASPASE 8; CASPASE 9; FAS ANTIGEN; GALACTOSE; PERINDOPRIL; PROTEIN BAX; PROTEIN BCL 2; ALUMINUM CHLORIDE; ALUMINUM DERIVATIVE; CHLORIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPUS; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; DISEASE MODEL; DRUG EFFECTS; DRUG INTERACTION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOCHONDRION; NEUROTOXICITY SYNDROMES; PATHOLOGY; ULTRASTRUCTURE;

ALUMINUM COMPOUNDS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 8; CHLORIDES; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; FAS LIGAND PROTEIN; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GALACTOSE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; MALE; MICE; MITOCHONDRIA; NEUROTOXICITY SYNDROMES; PERINDOPRIL; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER;

EID: 84908298031     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2014.09.010     Document Type: Article

References (42)

1. Akifusa S., Kamio N., Shimazaki Y., Yamaguchi N., Nishihara T., Yamashita Y. Globular adiponectin-induced RAW 264 apoptosis is regulated by a reactive oxygen species-dependent pathway involving Bcl-2. Free Radic. Biol. Med. 2009, 46:1308-1316.
2. Bartley M.G., Marquardt K., Kirchhof D., Wilkins H.M., Patterson D., Linseman D.A. Overexpression of amyloid-beta protein precursor induces mitochondrial cxidative stress and activates the intrinsic apoptotic cascade. J. Alzheimers Dis. 2012, 28:855-868.
3. Braszko J.J., Karwowska-Polecka W., Halicka D., Gard P.R. Captopril and enalapril improve cognition and depressed mood in hypertensive patients. J. Basic Clin. Physiol. Pharmacol. 2003, 14:323-343.
4. Broughton B.R.S., Reutens D.C., Sobey C.G. Apoptotic mechanisms after cerebral ischemia. Stroke 2009, 40:E331-E339.
5. Cai X., Zhang H., Tong D., Tan Z., Han D., Ji F., Hu W. Corosolic acid triggers mitochondria and caspase-dependent apoptotic cell death in osteosarcoma MG-63 cells. Phytother. Res. 2011, 25:1354-1361.
6. Cangiano E., Marchesini J., Campo G., Francolini G., Fortini C., Carra G., Miccoli M., Ceconi C., Tavazzi L., Ferrari R. ACE inhibition modulates endothelial apoptosis and renewal via endothelial progenitor cells in patients with acute coronary syndromes. Am. J. Cardiovasc. Drugs 2011, 11:189-198.
7. Cui X., Zuo P., Zhang Q., Li X., Hu Y., Long J., Packer L., Liu J. Chronic systemic d-galactose exposure induces memory loss, neuro degeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J. Neurosci. Res. 2006, 84:647-654.
8. D'Amelio M., Cavallucci V., Cecconi F. Neuronal caspase-3 signaling: not only cell death. Cell Death Differ. 2010, 17:1104-1114.
9. Dong Y.F., Kataoka K., Tokutomi Y., Nako H., Nakamura T., Toyama K., Sueta D., Koibuchi N., Yamamoto E., Ogawa H., Kim-Mitsuyama S. Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease. FASEB J. 2011, 25:2911-2920.
10. Engidawork E., Gulesserian T., Yoo B.C., Cairns N., Lubec G. Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease. Biochem. Biophys. Res. Commun. 2001, 281:84-93.
11. Guimaraes C.A., Linden R. Programmed cell deaths - apoptosis and alternative deathstyles. Eur. J. Biochem. 2004, 271:1638-1650.
12. Hajjar I., Keown M., Frost B. Antihypertensive agents for aging patients who are at risk for cognitive dysfunction. Curr. Hypertens. 2005, 7:466-473.
13. He M., Zhao L., Wei M.J., Yao W.F., Zhao H.S., Chen F.J. Neuroprotective effects of (-)-epigallocatechin-3-gallate on aging mice induced by d-galactose. Pharm. Bull. 2009, 32:55-60.
14. Helzner E.P., Scarmeas N., Cosentino S., Tang M.X., Schupf N., Stern Y. Survival in Alzheimer disease A multiethnic, population-based study of incident cases. Neurology 2008, 71:1489-1495.
15. Ho S.C., Liu J.H., Wu R.Y.Y. Establishment of the mimetic aging effect in mice caused by d-galactose. Biogerontology 2003, 4:15-18.
16. Hou D.R., Wang Y., Zhou L., Chen K., Tian Y., Song Z., Bao J., Yang Q.D. Altered angiotensin-converting enzyme and its effects on the brain in a rat model of Alzheimer disease. Chin. Med. J. 2008, 121:2320-2323.
17. Huang S.H., Lin C.M., Chiang B.H. Protective effects of Angelica sinensis extract on amyloid beta-peptide-induced neurotoxicity. Phytomedicine 2008, 15:710-721.
18. Ivins K.J., Thornton P.L., Rohn T.T., Cotman C.W. Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8. Neurobiol. Dis. 1999, 6:440-449.
19. Kaizer R.R., Correa M.C., Gris L.R.S., da Rosa C.S., Bohrer D., Morsch V.M., Chitolina Schetinger M.R. Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes. Neurochem. Res. 2008, 33:2294-2301.
20. Khachaturian A.S., Zandi P.P., Lyketsos C.G., Hayden K.M., Skoog I., Norton M.C., Tschanz J.T., Mayer L.S., Welsh-Bohmer K.A., Breitner J.C.S. Antihypertensive medication use and incident Alzheimer disease - the Cache County Study. Arch. Neurol. 2006, 63:686-692.
21. Lei Y., Fu W., Chen J., Xiong C., Wu G., Wei H., Ruan J. Neuroprotective effects of Abacopterin E from Abacopteris penangiana against oxidative stress-induced neurotoxicity. J. Ethnopharmacol. 2011, 134:275-280.
22. Liang J.H., Du J., Xu L.D., Jiang T., Hao S., Bi J., Jiang B. Catalpol protects primary cultured cortical neurons induced by A beta(1-42) through a mitochondrial-dependent caspase pathway. Neurochem. Int. 2009, 55:741-746.
23. Love S. Apoptosis and brain ischaemia. Prog. Neuropsychopharmacol. Biol. Psychiatry 2003, 27:267-282.
24. Lovell M.A., Markesbery W.R. Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimers disease. Nucleic Acids Res. 2007, 35:7497-7504.
25. Lu D.C., Rabizadeh S., Chandra S., Shayya R.F., Ellerby L.M., Ye X., Salvesen G.S., Koo E.H., Bredesen D.E. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat. Med. 2000, 6:397-404.
26. Lu J., Wu D.M., Zheng Y.I., Hu B., Zhang Z.F. Purple Sweet Potato Color Alleviates d-galactose-induced brain aging in old mice by promoting survival of neurons via PI3K pathway and inhibiting cytochrome c-mediated apoptosis. Brain Pathol. 2010, 20:598-612.
27. Lu J., Zheng Y.L., Wu D.M., Luo L., Sun D.X., Shan Q. Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by d-galactose. Biochem. Pharmacol. 2007, 74:1078-1090.
28. Luo Y., Niu F., Sun Z., Cao W., Zhang X., Guan D., Lv Z., Zhang B., Xu Y. Altered expression of A beta metabolism-associated molecules from d-galactose/AlCl(3) induced mouse brain. Mech. Ageing Dev. 2009, 130:248-252.
29. Mueller W.E., Eckert A., Kurz C., Eckert G.P., Leuner K. Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease-therapeutic aspects. Mol. Neurobiol. 2010, 41:159-171.
30. Qian Y.H., Xiao Q., Chen H., Xu J. Dexamethasone inhibits camptothecin-induced apoptosis in C6-glioma via activation of Stat5/Bcl-xL pathway. Biochim. Biophys. Acta - Mol. Cell Res. 2009, 1793:764-771.
31. Roy S., Nicholson D.W. Cross-talk in cell death signaling. J. Exp. Med. 2000, 192:F21-F25.
32. Skoog I., Gustafson D. Hypertension, hypertension-clustering factors and Alzheimer's disease. Neurol. Res. 2003, 25:675-680.
33. Song C., Xiong S., Yin X., Wang H., Gong F. Class effects of several ACEIs on cadiocyte apoptosis and expression of caspase-3 and Fas/FasL genes in experimental diabetic rats. J. Wuhan. Univ. Med. 2008, 29:24-27.
34. Sugawara T., Fujimura M., Noshita N., Kim G.W., Saito A., Hayashi T., Narasimhan P., Maier C.M., Chan P.H. Neuronal death/survival signaling pathways in cerebral ischemia. Neuro. Rx. 2004, 1:17-25.
35. Sun H.L., Sun L., Li Y.Y., Shao M.M., Cheng X.Y., Ge N., Lu J.D., Li S.M. ACE-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats. Exp. Clin. Endocrinol. Diabetes 2009, 117:336-344.
36. Sun Z.Z., Chen Z.B., Jiang H., Li L.L., Li E.G., Xu Y. Alteration of A beta metabolism-related molecules in predementia induced by AlCl3 and d-galactose. Age. 2009, 31:277-284.
37. Valko M., Leibfritz D., Moncol J., Cronin M.T.D., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 2007, 39:44-84.
38. Wang J., Ho L., Chen L., Zhao Z., Zhao W., Qian X., Humala N., Seror I., Bartholomew S., Rosendorff C., Pasinetti G.M. Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. J. Clin. Invest. 2007, 117:3393-3402.
39. Yang W.N., Han H., Hu X.D., Feng G.F., Qian Y.H. The effects of perindopril on cognitive impairment induced by d-galactose and aluminum trichloride via inhibition of acetylcholinesterase activity and oxidative stress. Pharmacol. Biochem. Behav. 2013, 114:31-36.
40. Yang W.N., Wang J.J., Shi L.L., Yu L.H., Qian Y.H., Liu Y., Wang W.X., Cheng S.L. Podocyte injury and overexpression of vascular endothelial growth factor and transforming growth factor-beta 1 in adriamycin-induced nephropathy in rats. Cytokine 2012, 59:370-376.
41. Zhang H., Liu Y., Lao M., Ma Z., Yi X. Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways. Exp. Gerontol. 2011, 46:30-37.
42. Zhang Y., Goodyer C., LeBlanc A. Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3, -6, -7, and -8. J. Neurosci. 2000, 20:8384-8389.