Circular muscle contraction in the mice rectum plays a key role in morphine-induced constipation

Neurogastroenterology and Motility

Volumn 26, Issue 10, 2014, Pages 1396-1407

  Ono, H ^a   Nakamura, A ^a   Matsumoto, K ^b,c   Horie, S ^b   Sakaguchi, G ^a   Kanemasa, T ^a  

^a SHIONOGI AND CO LTD   (Japan)

^b JOSAI INTERNATIONAL UNIVERSITY   (Japan)

^c KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Constipation; Morphine; Nitric oxide (NO); Rectum; opioid receptor (MOR)

Indexed keywords

ARGININE; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; N(G) NITROARGININE METHYL ESTER; NALOXONE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; CONSTIPATION; CONTROLLED STUDY; DESCENDING COLON; HISTOPATHOLOGY; ILEUM; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTESTINE CONTRACTION; ISOMETRICS; JEJUNUM; LARGE INTESTINE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSVERSE COLON; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; PATHOPHYSIOLOGY; SMALL INTESTINE; SMOOTH MUSCLE;

ANIMALS; CONSTIPATION; INTESTINE, LARGE; INTESTINE, SMALL; MALE; MICE; MORPHINE; MUSCLE, SMOOTH; NITRIC OXIDE; RECEPTORS, OPIOID, MU; RECTUM;

EID: 84908260842     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12387     Document Type: Article

References (38)

1. Twycross RG, Lack SA. Control of Alimentary Symptoms in Far Advanced Cancer. London: Churchill Livingstone, 1986: 166-207.
2. Schug SA, Zech D, Grond S. Adverse effects of systemic opioid analgesics. Drug Saf 1992; 7: 200-13.
3. Holzer P, Ahmedzai SH, Niederle N, Leyendecker P, Hopp M, Bosse B, Spohr I, Reimer K. Opioid-induced bowel dysfunction in cancer-related pain: causes, consequences, and a novel approach for its management. Opioid Manag 2009; 5: 145-51.
4. Roy S, Liu HC, Loh HH. Mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit. Brain Res Mol Brain Res 1998; 56: 281-3.
5. Stewart JJ, Weisbrodt NW, Burks TF. Central and peripheral actions of morphine on intestinal transit. J Pharmacol Exp Ther 1978; 205: 547-55.
6. Mori T, Shibasaki Y, Matsumoto K, Shibasaki M, Hasegawa M, Wang E, Masukawa D, Yoshizawa K et al. Mechanisms that underlie μ-opioid receptor agonist-induced constipation; differential involvement of μ-opioid receptor sites and responsible regions. J Pharmacol Exp Ther 2013; 347: 91-9.
7. Daniel EE, Sutherland WH, Bogoch A. Effects of morphine and other drugs on motility of the terminal ileum. Gastroenterology 1959; 36: 510-23.
8. Tavani A, Bianchi G, Ferretti P, Manara L. Morphine is most effective on gastrointestinal propulsion in rats by intraperitoneal route: evidence for local action. Life Sci 1980; 27: 2211-7.
9. Foss JF, Bass AS, Goldberg LI. Dose-related antagonism of the emetic effect of morphine by methylnaltrexone in dogs. J Clin Pharmacol 1993; 33: 747-51.
10. Gatti A, Sabato AF. Management of opioid-induced constipation in cancer patients: focus on methylnaltrexone. Clin Drug Investig 2012; 32: 293-301.
11. DeHaven-Hudkins DL, DeHaven RN, Little PJ, Techner LM. The involvement of the mu-opioid receptor in gastrointestinal pathophysiology: therapeutic opportunities for antagonism at this receptor. Pharmacol Ther 2008; 117: 162-87.
12. Sternini C, Spann M, Anton B, Keith DE Jr, Bunnett NW, von Zastrow M, Evans C, Brecha NC. Agonist-selective endocytosis of mu opioid receptor by neurons in vivo. Proc Natl Acad Sci U S A 1996; 93: 9241-6.
13. Bagnol D, Mansour A, Akil H, Watson SJ. Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract. Neuroscience 1997; 81: 579-91.
14. Kromer W. Endogenous and exogenous opioids in the control of gastrointestinal motility and secretion. Pharmacol Rev 1988; 40: 121-62.
15. Wood JD, Galligan JJ. Function of opioids in the enteric nervous system. Neurogastroenterol Motil 2004; 16: 17-28.
16. Iwata H, Tsuchiya S, Nakamura T, Yano S. Morphine leads to contraction of the ileal circular muscle via inhibition of the nitrergic pathway in mice. Eur J Pharmacol 2007; 574: 66-70.
17. Bitar KN, Makhlouf GM. Selective presence of opiate receptors on intestinal circular muscle cells. Life Sci 1985; 37: 1545-50.
18. Kosterlitz HW, Lees GM. Pharmacological analysis of intrinsic intestinal reflexes. Pharmacol Rev 1964; 16: 301-39.
19. Lénárd L Jr, Halmai V, Barthó L. Morphine contracts the guinea pig ileal circular muscle by interfering with a nitric oxide mediated tonic inhibition. Digestion 1999; 60: 562-6.
20. Ross GR, Gabra BH, Dewey WL, Akbarali HI. Morphine tolerance in the mouse ileum and colon. J Pharmacol Exp Ther 2008; 327: 561-72.
21. Kang M, Maguma HT, Smith TH, Ross GR, Dewey WL, Akbarali HI. The role of β-arrestin2 in the mechanism of morphine tolerance in the mouse and guinea pig gastrointestinal tract. J Pharmacol Exp Ther 2012; 340: 567-76.
22. Coates MD, Johnson AC, Greenwood-Van Meerveld B, Mawe GM. Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse. Neurogastroenterol Motil 2006; 18: 464-71.
23. Raehal KM, Schmid CL, Medvedev IO, Gainetdinov RR, Premont RT, Bohn LM. Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6. Drug Alcohol Depend 2009; 104: 187-96.
24. Smith TH, Grider JR, Dewey WL, Akbarali HI. Morphine decreases enteric neuron excitability via inhibition of sodium channels. PLoS ONE 2012; 7: e45251.
25. Majumdar S, Grinnell S, Le Rouzic V, Burgman M, Polikar L, Ansonoff M, Pintar J, Pan YX et al. Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects. Proc Natl Acad Sci USA 2011; 108: 19778-83.
26. Baccari MC, Traini C, Garella R, Cipriani G, Vannucchi MG. Relaxin exerts two opposite effects on mechanical activity and nitric oxide synthase expression in the mouse colon. Am J Physiol Endocrinol Metab 2012; 303: E1142-50.
27. Smith CF, Waldron C, Brook NA. Opioid receptors in the mouse ileum. Arch Int Pharmacodyn Ther 1988; 291: 122-31.
28. Raehal KM, Walker JK, Bohn LM. Morphine side effects in beta-arrestin 2 knockout mice. J Pharmacol Exp Ther 2005; 314: 1195-201.
29. Maguma HT, Dewey WL, Akbarali HI. Differences in the characteristics of tolerance to μ-opioid receptor agonists in the colon from wild type and β-arrestin2 knockout mice. Eur J Pharmacol 2012; 685: 133-40.
30. Whalen EJ, Rajagopal S, Lefkowitz RJ. Therapeutic potential of β-arrestin- and G protein-biased agonists. Trends Mol Med 2011; 17: 126-39.
31. Shafik A, Doss S, Asaad S, Ali YA. Rectosigmoid junction: anatomical, histological, and radiological studies with special reference to a sphincteric function. Int J Colorectal Dis 1999; 14: 237-44.
32. Manaka H, Manaka Y, Kostolanska F, Fox JE, Daniel EE. Release of VIP and substance P from isolated perfused canine ileum. Am J Physiol 1989; 257: G182-90.
33. Foxx-Orenstein AE, Grider JR. Regulation of colonic propulsion by enteric excitatory and inhibitory neurotransmitters. Am J Physiol 1996; 271: G433-7.
34. Takahashi T, Owyang C. Regional differences in the nitrergic innervation between the proximal and the distal colon in rats. Gastroenterology 1998; 115: 1504-12.
35. Stefano GB, Zhu W, Cadet P, Bilfinger TV, Mantione K. Morphine enhances nitric oxide release in the mammalian gastrointestinal tract via the μ3 opiate receptor subtype: a hormonal role for endogenous morphine. J Physiol Pharmacol 2004; 55: 279-88.
36. Stefano GB. Autoimmunovascular regulation: morphine and anandamide and ancondamide stimulated nitric oxide release. J Neuroimmunol 1998; 83: 70-6.
37. Christiansen J, Rasmussen OO. Colectomy for severe slow-transit constipation in strictly selected patients. Scand J Gastroenterol 1996; 31: 770-3.
38. McMillan SC. Assessing and managing opiate-induced constipation in adults with cancer. Cancer Control 2004; 11: 3-9.