Morphine leads to contraction of the ileal circular muscle via inhibition of the nitrergic pathway in mice

European Journal of Pharmacology

Volumn 574, Issue 1, 2007, Pages 66-70

  Iwata, Hiroki ^a   Tsuchiya, Shizuko ^a   Nakamura, Tomonori ^a   Yano, Shingo ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Circular muscle contraction; Morphine; Mouse ileum; Nitric oxide; Opioid receptor

Indexed keywords

ATROPINE; CYPRODIME; INDOMETACIN; MORPHINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; N(G) NITROARGININE; NALOXONE; NITRIC OXIDE; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLINERGIC NERVE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; ELECTROSTIMULATION; ILEUM; INTESTINE MUSCLE; INTESTINE TRANSIT TIME; MALE; MOUSE; MUSCLE CONTRACTION; MUSCLE RELAXATION; NITRERGIC NERVE; NONHUMAN; PERISTALSIS; PRIORITY JOURNAL; SMALL INTESTINE;

ANIMALS; ELECTRIC STIMULATION; ILEUM; MALE; MICE; MORPHINE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NITRERGIC NEURONS; NITRIC OXIDE; RECEPTORS, OPIOID, MU;

EID: 34848866879     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.06.029     Document Type: Article

References (16)

1. Frances B., Gout R., Monsarrat B., Cros J., and Zajac J.M. Further evidence that morphine-6β-glucuronide is a more potent opioid agonist than morphine. J. Pharmacol. Exp. Ther. 262 (1992) 25-31
2. Fujita A., Okishio Y., Fujinami K., Nakagawa M., Takeuchi T., Takewaki T., and Hata F. Role of the interstitial cells distributed in the myenteric plexus in neural reflexes in the mouse ileum. J. Pharmacol. Sci. 96 (2004) 483-492
3. Gallantine E.L., and Meert T.F. A comparison of the antinociceptive and adverse effects of the μ-opioid agonist morphine and the δ-opioid agonist SNC80. Basic Clin. Pharmacol. Toxicol. 97 (2005) 39-51
4. Gray A.C., Coupar I.M., and White P.J. Comparison of opioid receptor distributions in the rat ileum. Life Sci. 78 (2006) 1610-1616
5. Grider J.R. Interplay of somatostatin, opioid, and GABA neurons in the regulation of the peristaltic reflex. Am. J. Physiol. 267 (1994) G696-G701
6. Grider J.R. Neurotransmitters mediating the intestinal peristaltic reflex in the mouse. J. Pharmacol. Exp. Ther. 307 (2003) 460-467
7. 2+ concentration on the inhibitory effect of adenosine in guinea-pig ileal longitudinal muscles. Jpn. J. Pharmacol. 31 (1981) 141-143
8. Ivancheva C., and Radomirov R. Control of non-adrenergic non-cholinergic reflex motor responses in circular muscle of guinea-pig small intestine by Met-enkephalin. Auton. Autacoid Pharmacol. 22 (2002) 199-207
9. Lenard Jr. L., Halmai V., and Bartho L. Morphine contracts the guinea pig ileal circular muscle by interfering with a nitric oxide mediated tonic inhibition. Digestion 60 (1999) 562-566
10. Mignat C., Wille U., and Ziegler A. Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes. Life Sci. 56 (1995) 793-799
11. Nakamura T., Sakai A., Isogami I., Noda K., Ueno K., and Yano S. Abatement of morphine-induced slowing in gastrointestinal transit by Dai-kenchu-to, a traditional Japanese herbal medicine. Jpn. J. Pharmacol. 88 (2002) 217-221
12. Shaw J.S. Characterization of opiate receptors in the isolated rat rectum. Br. J. Pharmacol. 67 (1979) 428-429
13. Shimo Y., and Ishii T. Effects of morphine on non-adrenergic inhibitory responses of the guinea-pig taenia coli. J. Pharm. Pharmacol. 30 (1978) 596-597
14. Smith C.F.C., Waldron C., and Brook N.A. Opioid receptors in the mouse ileum. Arch. Int. Pharmacodyn. Ther. 291 (1988) 122-131
15. Sternini C., Patierno S., Selmer I.S., and Kirchgessner A. The opioid system in the gastrointestinal tract. Neurogastroenterol. Motil. 16 Suppl. 2 (2004) 3-16
16. Tan-No K., Niijima F., Nakagawasai O., Sato T., Satoh S., and Tadano T. Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice. Eur. J. Pharm.Sci. 20 (2003) 357-363