Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 49, 2011, Pages 19778-19783

  Majumdar, Susruta ^a   Grinnell, Steven ^a   Le Rouzic, Valerie ^a   Burgman, Maxim ^a   Polikar, Lisa ^a   Ansonoff, Michael ^b   Pintar, John ^b   Pan, Ying Xian ^a   Pasternak, Gavril W ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Kappa 3 receptor; Opiate receptor; Rewarding behavior

Indexed keywords

BUTORPHANOL; G PROTEIN COUPLED RECEPTOR; IODOBENZOYLNALTREXAMIDE; KETAZOCINE; LEVALLORPHAN; LEVORPHANOL; MORPHINE; MU OPIATE RECEPTOR; NALBUPHINE; NALOXONE; NALTREXONE DERIVATIVE; OPIATE; TRUNCATED G PROTEIN COUPLED MU OPIOID RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONSTIPATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DEPENDENCE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG TOLERANCE; GENE TARGETING; HETERODIMERIZATION; MALE; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REINFORCEMENT; RESPIRATION DEPRESSION;

ALTERNATIVE SPLICING; ANALGESICS, OPIOID; ANIMALS; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL MOTILITY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR STRUCTURE; NALTREXONE; PAIN; PAIN MEASUREMENT; PROTEIN ISOFORMS; PROTEIN MULTIMERIZATION; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, OPIOID, MU; TIME FACTORS;

EID: 83755177882     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1115231108     Document Type: Article

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