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Volumn 32, Issue 5, 2012, Pages 293-301

Management of opioid-induced constipation in cancer patients: Focus on methylnaltrexone

Author keywords

[No Author keywords available]

Indexed keywords

17 METHYLNALTREXONE; METHADONE; OPIATE;

EID: 84859803846     PISSN: 11732563     EISSN: 11791918     Source Type: Journal    
DOI: 10.2165/11598000-000000000-00000     Document Type: Review
Times cited : (26)

References (40)
  • 1
    • 79959330281 scopus 로고    scopus 로고
    • Methylnaltrexone: The evidence for its use in the management of opioid-induced constipation
    • Deibert P, Xander C, Blum HE, et al. Methylnaltrexone: The evidence for its use in the management of opioid-induced constipation. Core Evid 2010; 4: 247-258
    • (2010) Core Evid , vol.4 , pp. 247-258
    • Deibert, P.1    Xander, C.2    Blum, H.E.3
  • 2
    • 77954437456 scopus 로고    scopus 로고
    • Cancer pain. Part 2: Physical, interventional and complimentary therapies; management in the community; acute, treatment-related and complex cancer pain. A perspective from the British pain society endorsed by the UK association of palliative medicine and the royal college of general practitioners
    • Raphael J, Hester J, Ahmedzai S, et al. Cancer pain. Part 2: physical, interventional and complimentary therapies; management in the community; acute, treatment-related and complex cancer pain. A perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners. Pain Med 2010; 11: 872-896
    • (2010) Pain Med. , vol.11 , pp. 872-896
    • Raphael, J.1    Hester, J.2    Ahmedzai, S.3
  • 3
    • 77953799914 scopus 로고    scopus 로고
    • Is the WHO analgesic ladder still valid? Twenty-four years of experience
    • e202-5
    • Vargas-Schaffer G. Is the WHO analgesic ladder still valid? Twenty-four years of experience. Can Fam Physician 2010; 56: 514-7, e202-5
    • (2010) Can. Fam. Physician , vol.56 , pp. 514-517
    • Vargas-Schaffer, G.1
  • 4
    • 67650284128 scopus 로고    scopus 로고
    • Detailing of gastrointestinal symptoms in cancer patients with advanced disease: New methodologies, new insights, and a proposed approach
    • Abernethy AP, Wheeler JL, Zafar SY. Detailing of gastrointestinal symptoms in cancer patients with advanced disease: New methodologies, new insights, and a proposed approach. Curr Opin Support Palliat Care 2009; 3: 41-49
    • (2009) Curr. Opin. Support Palliat Care , vol.3 , pp. 41-49
    • Abernethy, A.P.1    Wheeler, J.L.2    Zafar, S.Y.3
  • 5
    • 34247516968 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network V.1. [online]. Available from URL [Accessed 2011 Mar 2]
    • National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: Palliative care. V.1.2010 [online]. Available from URL: Http://www.nccn.org/professionals/physician-gls/pdf/palliative.pdf [Accessed 2011 Mar 2]
    • (2010) NCCN Clinical Practice Guidelines in Oncology: Palliative Care
  • 6
    • 84859788099 scopus 로고    scopus 로고
    • National Health Service Scotland. Available from URL [Accessed Mar 2]
    • National Health Service Scotland. Palliative care guidelines: constipation [online]. Available from URL: Http://www. palliativecareguidelines. scot.nhs.uk/documents/Constipation final.pdf [Accessed 2011 Mar 2]
    • (2011) Palliative Care Guidelines: Constipation [Online]
  • 8
    • 79551495140 scopus 로고    scopus 로고
    • Update on the management of constipation in the elderly: New treatment options
    • Rao SS, Go JT. Update on the management of constipation in the elderly: New treatment options. Clin Interv Aging 2010; 5: 163-171
    • (2010) Clin. Interv. Aging , vol.5 , pp. 163-171
    • Rao, S.S.1    Go, J.T.2
  • 9
    • 16444366557 scopus 로고    scopus 로고
    • Alvimopan, a selective peripherally acting μ-opioid antagonist
    • DOI 10.1111/j.1365-2982.2005.00640.x
    • Camilleri M. Alvimopan, a selective peripherally acting mu-opioid antagonist. Neurogastroenterol Motil 2005; 17: 157-65 (Pubitemid 40476675)
    • (2005) Neurogastroenterology and Motility , vol.17 , Issue.2 , pp. 157-165
    • Camilleri, M.1
  • 10
    • 0022546230 scopus 로고
    • Inhibition of gastrointestinal transit by morphine in rats results primarily from direct drug action on gut opioid sites
    • Manara L, Bianchi G, Ferretti P, et al. Inhibition of gastrointestinal transit by morphine in rats results primarily from direct drug action on gut opioid sites. J Pharmacol Exp Ther 1986; 237: 945-949 (Pubitemid 16088118)
    • (1986) Journal of Pharmacology and Experimental Therapeutics , vol.237 , Issue.3 , pp. 945-949
    • Manara, L.1    Bianchi, G.2    Ferretti, P.3    Tavani, A.4
  • 11
    • 0019195675 scopus 로고
    • Morphine is most effective on gastrointestinal propulsion in rats by intraperitoneal route: Evidence for local action
    • DOI 10.1016/0024-3205(80)90386-0
    • TaVani A, Bianchi G, Ferretti P, et al. Morphine is most effective on gastrointestinal propulsion in rats by intraperitoneal route: evidence for local action. Life Sci 1980; 27: 2211-7 (Pubitemid 11177362)
    • (1980) Life Sciences , vol.27 , Issue.23 , pp. 2211-2217
    • Tavani, A.1    Bianchi, G.2    Ferretti, P.3    Manara, L.4
  • 12
    • 0002299213 scopus 로고
    • A study of the relative frequency and importance of gastrointestinal symptoms and weakness in patients with far advanced cancer: Student paper
    • Dunlop GM. A study of the relative frequency and importance of gastrointestinal symptoms and weakness in patients with far advanced cancer: Student paper. Palliat. Med. 1990; 4: 37-43
    • (1990) Palliat Med , vol.4 , pp. 37-43
    • Dunlop, G.M.1
  • 13
    • 0024583209 scopus 로고
    • Use of a modified symptom distress scale in assessment of the cancer patient
    • Holmes S. Use of a modified symptom distress scale in assessment of the cancer patient. Int J Nurs Stud 1989; 26: 69-79
    • (1989) Int. J. Nurs. Stud , vol.26 , pp. 69-79
    • Holmes, S.1
  • 14
    • 0036056767 scopus 로고    scopus 로고
    • Opioid antagonists: A review of their role in palliative care, focusing on use in opioid-related constipation
    • Choi YS, Billings JA. Opioid antagonists: A review of their role in palliative care, focusing on use in opioid-related constipation. J Pain Symptom Manage 2002; 24: 71-90
    • (2002) J. Pain Symptom. Manage , vol.24 , pp. 71-90
    • Choi, Y.S.1    Billings, J.A.2
  • 15
    • 34648816759 scopus 로고    scopus 로고
    • Introduction: The Rome foundation and Rome III
    • Drossman DA. Introduction: The Rome Foundation and Rome III. Neurogastroenterol Motil 2007; 19: 783-786
    • (2007) Neurogastroenterol Motil. , vol.19 , pp. 783-786
    • Drossman, D.A.1
  • 16
    • 34447258638 scopus 로고    scopus 로고
    • Cancer-related constipation
    • DOI 10.1007/s11912-007-0034-z
    • Thomas J. Cancer-related constipation. Curr Oncol Rep 2007; 9: 278-84 (Pubitemid 47045162)
    • (2007) Current Oncology Reports , vol.9 , Issue.4 , pp. 278-284
    • Thomas, J.1
  • 18
    • 34249732634 scopus 로고    scopus 로고
    • A review of methylnaltrexone, a peripheral opioid receptor antagonist, and its role in opioid-induced constipation
    • Shaiova L, Rim F, Friedman D, et al. A review of methylnaltrexone, a peripheral opioid receptor antagonist, and its role in opioid-induced constipation. Palliat Support Care 2007; 5: 161-166
    • (2007) Palliat. Support Care , vol.5 , pp. 161-166
    • Shaiova, L.1    Rim, F.2    Friedman, D.3
  • 19
    • 0032752321 scopus 로고    scopus 로고
    • Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: A pilot study
    • Yuan CS, Foss JF, O'ConnorM, et al. Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: A pilot study. Pain 1999; 83: 631-635
    • (1999) Pain , vol.83 , pp. 631-635
    • Yuan, C.S.1    Foss, J.F.2    O'Connor, M.3
  • 21
    • 0029971436 scopus 로고    scopus 로고
    • Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: A double-blind randomized placebo-controlled trial
    • DOI 10.1016/S0009-9236(96)90117-4
    • Yuan CS, Foss JF, O'Connor M, et al. Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: A double-blind randomized placebo-controlled trial. Clin Pharmacol Ther 1996; 59: 469-75 (Pubitemid 26151630)
    • (1996) Clinical Pharmacology and Therapeutics , vol.59 , Issue.4 , pp. 469-475
    • Yuan, C.-S.1    Foss, J.F.2    O'Connor, M.3    Toledano, A.4    Roizen, M.F.5    Moss, J.6
  • 23
    • 0036139012 scopus 로고    scopus 로고
    • Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: A double-blind randomized placebo-controlled trial
    • DOI 10.1124/jpet.300.1.118
    • Yuan CS, Wei G, Foss JF, et al. Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: A double-blind randomized placebocontrolled trial. J Pharmacol Exp Ther 2002; 300: 118-23 (Pubitemid 34028517)
    • (2002) Journal of Pharmacology and Experimental Therapeutics , vol.300 , Issue.1 , pp. 118-123
    • Yuan, C.-S.1    Wei, G.2    Foss, J.F.3    O'Connor, M.4    Karrison, T.5    Osinski, J.6
  • 25
    • 0020050607 scopus 로고
    • Quaternary narcotic antagonists' relative ability to prevent antinociception and gastrointestinal transit inhibition in morphine-treated rats as an index of peripheral selectivity
    • DOI 10.1016/0024-3205(82)90467-2
    • Bianchi G, Fiocchi R, TaVani A, et al. Quaternary narcotic antagonists'relative ability to prevent antinociception and gastrointestinal transit inhibition in morphine-Treated rats as an index of peripheral selectivity. Life Sci 1982; 30: 1875-83 (Pubitemid 12098880)
    • (1982) Life Sciences , vol.30 , Issue.22 , pp. 1875-1883
    • Bianchi, G.1    Fiocchi, R.2    Tavani, A.3    Manara, L.4
  • 26
    • 0022657226 scopus 로고
    • Independent central and peripheral mediation of morphine-induced inhibition of gastrointestinal transit in rats
    • Gmerek DE, Cowan A, Woods JH. Independent central and peripheral mediation of morphine-induced inhibition of gastrointestinal transit in rats. J Pharmacol Exp Ther 1986; 236: 8-13 (Pubitemid 16186117)
    • (1986) Journal of Pharmacology and Experimental Therapeutics , vol.236 , Issue.1 , pp. 8-13
    • Gmerek, D.E.1    Cowan, A.2    Woods, J.H.3
  • 27
    • 0025909317 scopus 로고
    • Role of central versus peripheral opioid receptors in analgesia induced by repeated administration of opioid antagonists
    • (Berl)
    • Walker MJ, Le AD, Poulos CX, et al. Role of central versus peripheral opioid receptors in analgesia induced by repeated administration of opioid antagonists. Psychopharmacology (Berl) 1991; 104: 164-166
    • (1991) Psychopharmacology , vol.104 , pp. 164-166
    • Walker, M.J.1    Le, A.D.2    Poulos, C.X.3
  • 28
    • 77951760826 scopus 로고    scopus 로고
    • Methylnaltrexone potentiates the anti-Angiogenic effects of mTOR inhibitors
    • Singleton PA, Mambetsariev N, Lennon FE, et al. Methylnaltrexone potentiates the anti-Angiogenic effects of mTOR inhibitors. J Angiogenes Res 2010; 2: 5
    • (2010) J. Angiogenes Res. , vol.2 , pp. 5
    • Singleton, P.A.1    Mambetsariev, N.2    Lennon, F.E.3
  • 29
    • 68549107734 scopus 로고    scopus 로고
    • Methylnaltrexone, a peripherally acting opioid receptor antagonist, enhances tumoricidal effects of 5-Fu on human carcinoma cells
    • Wang CZ, Li XL, Sun S, et al. Methylnaltrexone, a peripherally acting opioid receptor antagonist, enhances tumoricidal effects of 5-Fu on human carcinoma cells. Anticancer Res 2009; 29: 2927-32
    • (2009) Anticancer Res. , vol.29 , pp. 2927-32
    • Wang, C.Z.1    Li, X.L.2    Sun, S.3
  • 30
    • 75649129392 scopus 로고    scopus 로고
    • Methylnaltrexone potentiates body weight and fat reduction with leptin
    • Yuan CS, Sun S, Attele A, et al. Methylnaltrexone potentiates body weight and fat reduction with leptin. J Opioid Manag 2009; 5: 373-378
    • (2009) J. Opioid. Manag , vol.5 , pp. 373-378
    • Yuan, C.S.1    Sun, S.2    Attele, A.3
  • 31
    • 70349221129 scopus 로고    scopus 로고
    • Methylnaltrexone reduced body weight gain in ob/ob mice
    • Yuan CS, Wang CZ, Attele A, et al. Methylnaltrexone reduced body weight gain in ob/ob mice. J Opioid Manag 2009; 5: 213-218
    • (2009) J. Opioid. Manag , vol.5 , pp. 213-218
    • Yuan, C.S.1    Wang, C.Z.2    Attele, A.3
  • 32
    • 34250619981 scopus 로고    scopus 로고
    • Reversal of opioidinduced bladder dysfunction by intravenous naloxone and methylnaltrexone
    • Rosow CE, Gomery P, Chen TY, et al. Reversal of opioidinduced bladder dysfunction by intravenous naloxone and methylnaltrexone. Clin Pharmacol Ther 2007; 82: 48-53
    • (2007) Clin. Pharmacol. Ther. , vol.82 , pp. 48-53
    • Rosow, C.E.1    Gomery, P.2    Chen, T.Y.3
  • 33
    • 58149313977 scopus 로고    scopus 로고
    • Reversal of opioidinduced gastric dysfunction in a critically ill burn patient after methylnaltrexone
    • Woo M, O'Connor M, Yuan CS, et al. Reversal of opioidinduced gastric dysfunction in a critically ill burn patient after methylnaltrexone. Anesth Analg 2008; 107: 1965-7
    • (2008) Anesth. Analg. , vol.107 , pp. 1965-7
    • Woo, M.1    O'Connor, M.2    Yuan, C.S.3
  • 34
    • 84859796246 scopus 로고    scopus 로고
    • European Medicines Agency. Available from URL [Accessed Jan 30]
    • European Medicines Agency. Relistor-(methylnaltrexone bromide solution) EU prescribing information [online]. Available from URL: Http://www.ema.europa. eu/ema/in dex.jsp?curl=pages/medicines/human/medicines/000870/ human-med-001022.jsp&murl=menus/medicines/medici nes.jsp&mid= WC0b01ac058001d125 [Accessed 2011 Jan 30]
    • (2011) Relistor-(Methylnaltrexone Bromide Solution) EU Prescribing Information [Online]
  • 35
    • 79960720836 scopus 로고    scopus 로고
    • Pfizer. Relistor. Available from URL [Accessed Jan 30]
    • Pfizer. Relistor. Highlights of prescribing information [online]. Available from URL: Http://www.pfizerpro.com/ content/showlabeling.asp?id=499. [Accessed 2011 Jan 30]
    • (2011) Highlights of Prescribing Information [Online]
  • 36
    • 42649091132 scopus 로고    scopus 로고
    • Subcutaneous methylnaltrexone for the treatment of opioid-induced constipation in patients with advanced illness: A double-blind, randomized, parallel group, dose-ranging study
    • DOI 10.1016/j.jpainsymman.2007.12.005, PII S0885392408000936
    • Portenoy RK, Thomas J, Moehl Boatwright ML, et al. Subcutaneous methylnaltrexone for the treatment of opioidinduced constipation in patients with advanced illness: A double-blind, randomized, parallel group, dose-ranging study. J Pain Symptom Manage 2008; 35: 458-68 (Pubitemid 351601995)
    • (2008) Journal of Pain and Symptom Management , vol.35 , Issue.5 , pp. 458-468
    • Portenoy, R.K.1    Thomas, J.2    Moehl Boatwright, M.L.3    Tran, D.4    Galasso, F.L.5    Stambler, N.6    Von Gunten, C.F.7    Israel, R.J.8
  • 37
    • 64849097928 scopus 로고    scopus 로고
    • Methylnaltrexone for treatment of opioid-induced constipation in advanced illness patients
    • Slatkin N, Thomas J, Lipman AG, et al. Methylnaltrexone for treatment of opioid-induced constipation in advanced illness patients. J Support Oncol 2009; 7: 39-46
    • (2009) J. Support Oncol. , vol.7 , pp. 39-46
    • Slatkin, N.1    Thomas, J.2    Lipman, A.G.3
  • 38
    • 77949715460 scopus 로고    scopus 로고
    • Methylnaltrexone bromide for the treatment of opioid-induced constipation in patients with advanced illness: A cost-effectiveness analysis
    • Earnshaw SR, Klok RM, Iyer S, et al. Methylnaltrexone bromide for the treatment of opioid-induced constipation in patients with advanced illness: A cost-effectiveness analysis. Aliment Pharmacol Ther 2010; 31: 911-21
    • (2010) Aliment Pharmacol. Ther. , vol.31 , pp. 911-921
    • Earnshaw, S.R.1    Klok, R.M.2    Iyer, S.3
  • 39
    • 38049066540 scopus 로고    scopus 로고
    • Methylnaltrexone, a new peripheral mu-receptor antagonist for the prevention and treatment of opioid-induced extracerebral side effects
    • Reichle FM, Conzen PF. Methylnaltrexone, a new peripheral mu-receptor antagonist for the prevention and treatment of opioid-induced extracerebral side effects. Curr Opin Investig Drugs 2008; 9: 90-100
    • (2008) Curr. Opin. Investig. Drugs , vol.9 , pp. 90-100
    • Reichle, F.M.1    Conzen, P.F.2
  • 40
    • 33646455888 scopus 로고    scopus 로고
    • Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effects
    • Yuan CS, Israel RJ. Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effects. Expert Opin Investig Drugs 2006; 15: 541-52
    • (2006) Expert Opin. Investig. Drugs , vol.15 , pp. 541-552
    • Yuan, C.S.1    Israel, R.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.