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Volumn 5, Issue 7, 2014, Pages 697-702

Effector triggered immunity activation of innate immunity in metazoans by bacterial effectors

Author keywords

Actin cytoskeleton; Animal cells; DAMP; Innate immunity; MAMP; Metazoans; PAMP; Pore forming toxin; PRR; Translation inhibition

Indexed keywords

BACTERIAL TOXIN; EFFECTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PATTERN RECOGNITION RECEPTOR; PORE FORMING CYTOTOXIC PROTEIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR; BACTERIAL PROTEIN; BACTERIAL SECRETION SYSTEM;

EID: 84908229298     PISSN: 21505594     EISSN: 21505608     Source Type: Journal    
DOI: 10.4161/viru.29091     Document Type: Review
Times cited : (58)

References (80)
  • 1
    • 5444234216 scopus 로고    scopus 로고
    • The interface between innate and adaptive immunity
    • PMID:15454919
    • Hoebe K, Janssen E, Beutler B. The interface between innate and adaptive immunity. Nat Immunol 2004; 5:971-4; PMID:15454919; http://dx.doi.org/10.1038/ni1004-971
    • (2004) Nat Immunol , vol.5 , pp. 971-974
    • Hoebe, K.1    Janssen, E.2    Beutler, B.3
  • 2
    • 33846319348 scopus 로고    scopus 로고
    • The innate signaling of dangers and the dangers of innate signaling
    • PMID:17110939
    • Sansonetti PJ. The innate signaling of dangers and the dangers of innate signaling. Nat Immunol 2006; 7:1237-42; PMID:17110939; http://dx.doi.org/10.1038/ni1420
    • (2006) Nat Immunol , vol.7 , pp. 1237-1242
    • Sansonetti, P.J.1
  • 3
    • 34548064499 scopus 로고    scopus 로고
    • Interactions of bacterial effector proteins with host proteins
    • PMID:17662586
    • Mattoo S, Lee YM, Dixon JE. Interactions of bacterial effector proteins with host proteins. Curr Opin Immunol 2007; 19:392-401; PMID:17662586; http://dx.doi.org/10.1016/j.coi.2007.06.005
    • (2007) Curr Opin Immunol , vol.19 , pp. 392-401
    • Mattoo, S.1    Lee, Y.M.2    Dixon, J.E.3
  • 4
    • 78650153662 scopus 로고    scopus 로고
    • Pathogen-mediated posttranslational modifications: A re-emerging field
    • PMID:21111231
    • Ribet D, Cossart P. Pathogen-mediated posttranslational modifications: A re-emerging field. Cell 2010; 143:694-702; PMID:21111231; http://dx.doi.org/10.1016/j.cell.2010.11.019
    • (2010) Cell , vol.143 , pp. 694-702
    • Ribet, D.1    Cossart, P.2
  • 5
    • 79952203418 scopus 로고    scopus 로고
    • Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila
    • PMID:21390206
    • Fontana MF, Banga S, Barry KC, Shen X, Tan Y, Luo ZQ, Vance RE. Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog 2011; 7:e1001289; PMID:21390206; http://dx.doi.org/10.1371/journal.ppat.1001289
    • (2011) PLoS Pathog , vol.7
    • Fontana, M.F.1    Banga, S.2    Barry, K.C.3    Shen, X.4    Tan, Y.5    Luo, Z.Q.6    Vance, R.E.7
  • 6
    • 80052153210 scopus 로고    scopus 로고
    • Two signal models in innate immunity
    • PMID:21884165
    • Fontana MF, Vance RE. Two signal models in innate immunity. Immunol Rev 2011; 243:26-39; PMID:21884165; http://dx.doi.org/10.1111/j.1600-065X.2011.01037.x
    • (2011) Immunol Rev , vol.243 , pp. 26-39
    • Fontana, M.F.1    Vance, R.E.2
  • 7
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • PMID:16497588
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124:783-801; PMID:16497588; http://dx.doi.org/10.1016/j. cell.2006.02.015
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 8
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • PMID:20303872
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010; 140:805-20; PMID:20303872; http://dx.doi.org/10.1016/j. cell.2010.01.022
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 9
    • 34548608447 scopus 로고    scopus 로고
    • Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
    • PMID:17889651
    • Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 2007; 130:1071-82; PMID:17889651; http://dx.doi.org/10.1016/j.cell.2007.09.008
    • (2007) Cell , vol.130 , pp. 1071-1082
    • Jin, M.S.1    Kim, S.E.2    Heo, J.Y.3    Lee, M.E.4    Kim, H.M.5    Paik, S.G.6    Lee, H.7    Lee, J.O.8
  • 10
    • 70350441863 scopus 로고    scopus 로고
    • Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
    • PMID:19801985
    • Barbalat R, Lau L, Locksley RM, Barton GM. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol 2009; 10:1200-7; PMID:19801985; http://dx.doi.org/10.1038/ni.1792
    • (2009) Nat Immunol , vol.10 , pp. 1200-1207
    • Barbalat, R.1    Lau, L.2    Locksley, R.M.3    Barton, G.M.4
  • 11
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • PMID:11951032
    • Matzinger P. The danger model: a renewed sense of self. Science 2002; 296:301-5; PMID:11951032; http://dx.doi.org/10.1126/science.1071059
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 13
  • 14
    • 58849134296 scopus 로고    scopus 로고
    • Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2
    • PMID:18952897
    • He RL, Zhou J, Hanson CZ, Chen J, Cheng N, Ye RD. Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2. Blood 2009; 113:429-37; PMID:18952897; http://dx.doi.org/10.1182/blood-2008-03-139923
    • (2009) Blood , vol.113 , pp. 429-437
    • He, R.L.1    Zhou, J.2    Hanson, C.Z.3    Chen, J.4    Cheng, N.5    Ye, R.D.6
  • 15
    • 84878237993 scopus 로고    scopus 로고
    • Activation and regulation of the inflammasomes
    • PMID:23702978
    • Latz E, Xiao TS, Stutz A. Activation and regulation of the inflammasomes. Nat Rev Immunol 2013; 13:397-411; PMID:23702978; http://dx.doi.org/10.1038/nri3452
    • (2013) Nat Rev Immunol , vol.13 , pp. 397-411
    • Latz, E.1    Xiao, T.S.2    Stutz, A.3
  • 16
    • 66949122854 scopus 로고    scopus 로고
    • Approaching the asymptote: 20 years later
    • PMID:19538928
    • Medzhitov R. Approaching the asymptote: 20 years later. Immunity 2009; 30:766-75; PMID:19538928; http://dx.doi.org/10.1016/j.immuni.2009.06.004
    • (2009) Immunity , vol.30 , pp. 766-775
    • Medzhitov, R.1
  • 18
    • 75649093343 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the intestinal epithelium: How bacterial recognition shapes intestinal function
    • PMID:20098461
    • Abreu MT. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol 2010; 10:131-44; PMID:20098461; http://dx.doi.org/10.1038/nri2707
    • (2010) Nat Rev Immunol , vol.10 , pp. 131-144
    • Abreu, M.T.1
  • 19
    • 35648987280 scopus 로고    scopus 로고
    • Pathogen subversion of cell-intrinsic innate immunity
    • PMID:17952043
    • Roy CR, Mocarski ES. Pathogen subversion of cell-intrinsic innate immunity. Nat Immunol 2007; 8:1179-87; PMID:17952043; http://dx.doi.org/10.1038/ni1528
    • (2007) Nat Immunol , vol.8 , pp. 1179-1187
    • Roy, C.R.1    Mocarski, E.S.2
  • 20
    • 84856170491 scopus 로고    scopus 로고
    • How do plants achieve immunity? Defence without specialized immune cells
    • PMID:22273771
    • Spoel SH, Dong X. How do plants achieve immunity? Defence without specialized immune cells. Nat Rev Immunol 2012; 12:89-100; PMID:22273771; http://dx.doi.org/10.1038/nri3141
    • (2012) Nat Rev Immunol , vol.12 , pp. 89-100
    • Spoel, S.H.1    Dong, X.2
  • 21
    • 60849116153 scopus 로고    scopus 로고
    • Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology
    • PMID:19278550
    • Tseng TT, Tyler BM, Setubal JC. Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology. BMC Microbiol 2009; 9(Suppl 1):S2; PMID:19278550; http://dx.doi.org/10.1186/1471-2180-9-S1-S2
    • (2009) BMC Microbiol , vol.9 , pp. S2
    • Tseng, T.T.1    Tyler, B.M.2    Setubal, J.C.3
  • 22
    • 63549137674 scopus 로고    scopus 로고
    • Secretion and subcellular localizations of bacterial proteins: A semantic awareness issue
    • PMID:19299134
    • Desvaux M, Hébraud M, Talon R, Henderson IR. Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue. Trends Microbiol 2009; 17:139-45; PMID:19299134; http://dx.doi.org/10.1016/j.tim.2009.01.004
    • (2009) Trends Microbiol , vol.17 , pp. 139-145
    • Desvaux, M.1    Hébraud, M.2    Talon, R.3    Henderson, I.R.4
  • 23
    • 33751100626 scopus 로고    scopus 로고
    • The plant immune system
    • PMID:17108957
    • Jones JD, Dangl JL. The plant immune system. Nature 2006; 444:323-9; PMID:17108957; http://dx.doi.org/10.1038/nature05286
    • (2006) Nature , vol.444 , pp. 323-329
    • Jones, J.D.1    Dangl, J.L.2
  • 24
    • 84875422919 scopus 로고    scopus 로고
    • Effector-triggered versus pattern-triggered immunity: How animals sense pathogens
    • PMID:23411798
    • Stuart LM, Paquette N, Boyer L. Effector-triggered versus pattern-triggered immunity: how animals sense pathogens. Nat Rev Immunol 2013; 13:199-206; PMID:23411798; http://dx.doi.org/10.1038/nri3398
    • (2013) Nat Rev Immunol , vol.13 , pp. 199-206
    • Stuart, L.M.1    Paquette, N.2    Boyer, L.3
  • 25
    • 3342901591 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways defend against bacterial poreforming toxins
    • PMID:15256590
    • Huffman DL, Abrami L, Sasik R, Corbeil J, van der Goot FG, Aroian RV. Mitogen-activated protein kinase pathways defend against bacterial poreforming toxins. Proc Natl Acad Sci U S A 2004; 101:10995-1000; PMID:15256590; http://dx.doi.org/10.1073/pnas.0404073101
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10995-11000
    • Huffman, D.L.1    Abrami, L.2    Sasik, R.3    Corbeil, J.4    Van Der Goot, F.G.5    Aroian, R.V.6
  • 26
    • 33748598700 scopus 로고    scopus 로고
    • Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
    • PMID:16990137
    • Gurcel L, Abrami L, Girardin S, Tschopp J, van der Goot FG. Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 2006; 126:1135-45; PMID:16990137; http://dx.doi.org/10.1016/j. cell.2006.07.033
    • (2006) Cell , vol.126 , pp. 1135-1145
    • Gurcel, L.1    Abrami, L.2    Girardin, S.3    Tschopp, J.4    Van Der Goot, F.G.5
  • 27
    • 84864606683 scopus 로고    scopus 로고
    • The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity
    • PMID:22829768
    • Bebien M, Hensler ME, Davanture S, Hsu LC, Karin M, Park JM, Alexopoulou L, Liu GY, Nizet V, Lawrence T. The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity. PLoS Pathog 2012; 8:e1002812; PMID:22829768; http://dx.doi.org/10.1371/journal. ppat.1002812
    • (2012) PLoS Pathog , vol.8 , pp. e1002812
    • Bebien, M.1    Hensler, M.E.2    Davanture, S.3    Hsu, L.C.4    Karin, M.5    Park, J.M.6    Alexopoulou, L.7    Liu, G.Y.8    Nizet, V.9    Lawrence, T.10
  • 28
    • 84860001887 scopus 로고    scopus 로고
    • Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction
    • PMID:22520462
    • Meinzer U, Barreau F, Esmiol-Welterlin S, Jung C, Villard C, Léger T, Ben-Mkaddem S, Berrebi D, Dussaillant M, Alnabhani Z, et al. Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction. Cell Host Microbe 2012; 11:337-51; PMID:22520462; http://dx.doi.org/10.1016/j.chom.2012.02.009
    • (2012) Cell Host Microbe , vol.11 , pp. 337-351
    • Meinzer, U.1    Barreau, F.2    Esmiol-Welterlin, S.3    Jung, C.4    Villard, C.5    Léger, T.6    Ben-Mkaddem, S.7    Berrebi, D.8    Dussaillant, M.9    Alnabhani, Z.10
  • 29
    • 70049109028 scopus 로고    scopus 로고
    • Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells
    • PMID:19662166
    • Bruno VM, Hannemann S, Lara-Tejero M, Flavell RA, Kleinstein SH, Galán JE. Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells. PLoS Pathog 2009; 5:e1000538; PMID:19662166; http://dx.doi.org/10.1371/journal.ppat.1000538
    • (2009) PLoS Pathog , vol.5 , pp. e1000538
    • Bruno, V.M.1    Hannemann, S.2    Lara-Tejero, M.3    Flavell, R.A.4    Kleinstein, S.H.5    Galán, J.E.6
  • 30
    • 84859773145 scopus 로고    scopus 로고
    • Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans
    • PMID:22520464
    • McEwan DL, Kirienko NV, Ausubel FM. Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans. Cell Host Microbe 2012; 11:364-74; PMID:22520464; http://dx.doi.org/10.1016/j.chom.2012.02.007
    • (2012) Cell Host Microbe , vol.11 , pp. 364-374
    • McEwan, D.L.1    Kirienko, N.V.2    Ausubel, F.M.3
  • 31
    • 84859773140 scopus 로고    scopus 로고
    • C. elegans detects pathogen-induced translational inhibition to activate immune signaling
    • PMID:22520465
    • Dunbar TL, Yan Z, Balla KM, Smelkinson MG, Troemel ER. C. elegans detects pathogen-induced translational inhibition to activate immune signaling. Cell Host Microbe 2012; 11:375-86; PMID:22520465; http://dx.doi.org/10.1016/j. chom.2012.02.008
    • (2012) Cell Host Microbe , vol.11 , pp. 375-386
    • Dunbar, T.L.1    Yan, Z.2    Balla, K.M.3    Smelkinson, M.G.4    Troemel, E.R.5
  • 32
    • 84867621165 scopus 로고    scopus 로고
    • Activation of host mitogen-activated protein kinases by secreted Legionella pneumophila effectors that inhibit host protein translation
    • PMID:22851749
    • Fontana MF, Shin S, Vance RE. Activation of host mitogen-activated protein kinases by secreted Legionella pneumophila effectors that inhibit host protein translation. Infect Immun 2012; 80:3570-5; PMID:22851749; http://dx.doi.org/10.1128/IAI.00557-12
    • (2012) Infect Immun , vol.80 , pp. 3570-3575
    • Fontana, M.F.1    Shin, S.2    Vance, R.E.3
  • 33
    • 81355160488 scopus 로고    scopus 로고
    • The WxxxE effector EspT triggers expression of immune mediators in an Erk/JNK and NF-κB-dependent manner
    • PMID:21848814
    • Raymond B, Crepin VF, Collins JW, Frankel G. The WxxxE effector EspT triggers expression of immune mediators in an Erk/JNK and NF-κB-dependent manner. Cell Microbiol 2011; 13:1881-93; PMID:21848814; http://dx.doi.org/10.1111/j.1462-5822.2011.01666.x
    • (2011) Cell Microbiol , vol.13 , pp. 1881-1893
    • Raymond, B.1    Crepin, V.F.2    Collins, J.W.3    Frankel, G.4
  • 34
    • 80755163546 scopus 로고    scopus 로고
    • Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway
    • PMID:22018470
    • Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, et al. Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway. Immunity 2011; 35:536-49; PMID:22018470; http://dx.doi.org/10.1016/j.immuni.2011.08.015
    • (2011) Immunity , vol.35 , pp. 536-549
    • Boyer, L.1    Magoc, L.2    Dejardin, S.3    Cappillino, M.4    Paquette, N.5    Hinault, C.6    Charriere, G.M.7    Ip, W.K.8    Fracchia, S.9    Hennessy, E.10
  • 35
    • 84883199752 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in innate immunity
    • PMID:23954936
    • Arthur JS, Ley SC. Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol 2013; 13:679-92; PMID:23954936; http://dx.doi.org/10.1038/nri3495
    • (2013) Nat Rev Immunol , vol.13 , pp. 679-692
    • Arthur, J.S.1    Ley, S.C.2
  • 36
    • 33750435582 scopus 로고    scopus 로고
    • NF-kappaB and the immune response
    • PMID:17072327
    • Hayden MS, West AP, Ghosh S. NF-kappaB and the immune response. Oncogene 2006; 25:6758-80; PMID:17072327; http://dx.doi.org/10.1038/sj.onc.1209943
    • (2006) Oncogene , vol.25 , pp. 6758-6780
    • Hayden, M.S.1    West, A.P.2    Ghosh, S.3
  • 37
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • PMID:19302050
    • Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 2009; 27:693-733; PMID:19302050; http://dx.doi.org/10.1146/annurev.immunol.021908.132641
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 38
    • 70349617469 scopus 로고    scopus 로고
    • Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
    • PMID:19797770
    • Buchon N, Broderick NA, Chakrabarti S, Lemaitre B. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev 2009; 23:2333-44; PMID:19797770; http://dx.doi.org/10.1101/gad.1827009
    • (2009) Genes Dev , vol.23 , pp. 2333-2344
    • Buchon, N.1    Broderick, N.A.2    Chakrabarti, S.3    Lemaitre, B.4
  • 39
    • 67650388208 scopus 로고    scopus 로고
    • Pathogenic stimulation of intestinal stem cell response in Drosophila
    • PMID:19452446
    • Chatterjee M, Ip YT. Pathogenic stimulation of intestinal stem cell response in Drosophila. J Cell Physiol 2009; 220:664-71; PMID:19452446; http://dx.doi.org/10.1002/jcp.21808
    • (2009) J Cell Physiol , vol.220 , pp. 664-671
    • Chatterjee, M.1    Ip, Y.T.2
  • 40
    • 84865188660 scopus 로고    scopus 로고
    • Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut
    • PMID:22817988
    • Chakrabarti S, Liehl P, Buchon N, Lemaitre B. Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut. Cell Host Microbe 2012; 12:60-70; PMID:22817988; http://dx.doi.org/10.1016/j. chom.2012.06.001
    • (2012) Cell Host Microbe , vol.12 , pp. 60-70
    • Chakrabarti, S.1    Liehl, P.2    Buchon, N.3    Lemaitre, B.4
  • 41
    • 79952403625 scopus 로고    scopus 로고
    • Comprehensive identification of protein substrates of the Dot/Icm type IV transporter of Legionella pneumophila
    • PMID:21408005
    • Zhu W, Banga S, Tan Y, Zheng C, Stephenson R, Gately J, Luo ZQ. Comprehensive identification of protein substrates of the Dot/Icm type IV transporter of Legionella pneumophila. PLoS One 2011; 6:e17638; PMID:21408005; http://dx.doi.org/10.1371/journal.pone.0017638
    • (2011) PLoS One , vol.6 , pp. e17638
    • Zhu, W.1    Banga, S.2    Tan, Y.3    Zheng, C.4    Stephenson, R.5    Gately, J.6    Luo, Z.Q.7
  • 42
    • 57649149094 scopus 로고    scopus 로고
    • The Legionella pneumophila replication vacuole: Making a cosy niche inside host cells
    • PMID:19011659
    • Isberg RR, O’Connor TJ, Heidtman M. The Legionella pneumophila replication vacuole: making a cosy niche inside host cells. Nat Rev Microbiol 2009; 7:13-24; PMID:19011659; http://dx.doi.org/10.1038/nrmicro1967
    • (2009) Nat Rev Microbiol , vol.7 , pp. 13-24
    • Isberg, R.R.1    O’connor, T.J.2    Heidtman, M.3
  • 43
    • 57149112520 scopus 로고    scopus 로고
    • Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila
    • PMID:19043549
    • Shin S, Case CL, Archer KA, Nogueira CV, Kobayashi KS, Flavell RA, Roy CR, Zamboni DS. Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila. PLoS Pathog 2008; 4:e1000220; PMID:19043549; http://dx.doi.org/10.1371/journal.ppat.1000220
    • (2008) PLoS Pathog , vol.4 , pp. e1000220
    • Shin, S.1    Case, C.L.2    Archer, K.A.3    Nogueira, C.V.4    Kobayashi, K.S.5    Flavell, R.A.6    Roy, C.R.7    Zamboni, D.S.8
  • 44
    • 79957568547 scopus 로고    scopus 로고
    • Using C. elegans for antimicrobial drug discovery
    • PMID:21686092
    • Desalermos A, Muhammed M, Glavis-Bloom J, Mylonakis E. Using C. elegans for antimicrobial drug discovery. Expert Opin Drug Discov 2011; 6:645-52; PMID:21686092; http://dx.doi.org/10.1517/174604 41.2011.573781
    • (2011) Expert Opin Drug Discov , vol.6 , pp. 645-652
    • Desalermos, A.1    Muhammed, M.2    Glavis-Bloom, J.3    Mylonakis, E.4
  • 45
    • 84896751347 scopus 로고    scopus 로고
    • Whole animal automated platform for drug discovery against multi-drug resistant Staphylococcus aureus
    • PMID:24586584
    • Rajamuthiah R, Fuchs BB, Jayamani E, Kim Y, Larkins-Ford J, Conery A, Ausubel FM, Mylonakis E. Whole animal automated platform for drug discovery against multi-drug resistant Staphylococcus aureus. PLoS One 2014; 9:e89189; PMID:24586584; http://dx.doi.org/10.1371/journal.pone.0089189
    • (2014) PLoS One , vol.9 , pp. e89189
    • Rajamuthiah, R.1    Fuchs, B.B.2    Jayamani, E.3    Kim, Y.4    Larkins-Ford, J.5    Conery, A.6    Ausubel, F.M.7    Mylonakis, E.8
  • 46
    • 84859765702 scopus 로고    scopus 로고
    • Inactivation of conserved C. elegans genes engages pathogen-and xenobiotic-associated defenses
    • PMID:22500807
    • Melo JA, Ruvkun G. Inactivation of conserved C. elegans genes engages pathogen-and xenobiotic-associated defenses. Cell 2012; 149:452-66; PMID:22500807; http://dx.doi.org/10.1016/j. cell.2012.02.050
    • (2012) Cell , vol.149 , pp. 452-466
    • Melo, J.A.1    Ruvkun, G.2
  • 47
    • 78049370513 scopus 로고    scopus 로고
    • Modulation of host cell function by Legionella pneumophila type IV effectors
    • PMID:20929312
    • Hubber A, Roy CR. Modulation of host cell function by Legionella pneumophila type IV effectors. Annu Rev Cell Dev Biol 2010; 26:261-83; PMID:20929312; http://dx.doi.org/10.1146/annurev-cellbio-100109-104034
    • (2010) Annu Rev Cell Dev Biol , vol.26 , pp. 261-283
    • Hubber, A.1    Roy, C.R.2
  • 49
    • 84869005068 scopus 로고    scopus 로고
    • Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulindependent kinase kinase-β (CaMKK-β)
    • PMID:23027865
    • Ghislat G, Patron M, Rizzuto R, Knecht E. Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulindependent kinase kinase-β (CaMKK-β). J Biol Chem 2012; 287:38625-36; PMID:23027865; http://dx.doi.org/10.1074/jbc.M112.365767
    • (2012) J Biol Chem , vol.287 , pp. 38625-38636
    • Ghislat, G.1    Patron, M.2    Rizzuto, R.3    Knecht, E.4
  • 50
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • PMID:20034776
    • Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010; 22:124-31; PMID:20034776; http://dx.doi.org/10.1016/j.ceb.2009.11.014
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 51
    • 14744299030 scopus 로고    scopus 로고
    • Regulation of innate immunity by Rho GTPases
    • PMID:15752980
    • Bokoch GM. Regulation of innate immunity by Rho GTPases. Trends Cell Biol 2005; 15:163-71; PMID:15752980; http://dx.doi.org/10.1016/j. tcb.2005.01.002
    • (2005) Trends Cell Biol , vol.15 , pp. 163-171
    • Bokoch, G.M.1
  • 52
    • 77649153819 scopus 로고    scopus 로고
    • WASP: A key immunological multitasker
    • PMID:20182458
    • Thrasher AJ, Burns SO. WASP: a key immunological multitasker. Nat Rev Immunol 2010; 10:182-92; PMID:20182458; http://dx.doi.org/10.1038/nri2724
    • (2010) Nat Rev Immunol , vol.10 , pp. 182-192
    • Thrasher, A.J.1    Burns, S.O.2
  • 53
    • 84860298639 scopus 로고    scopus 로고
    • Insulin receptor substrate protein 53kDa (IRSp53) is a negative regulator of myogenic differentiation
    • PMID:22465711
    • Misra A, George B, Rajmohan R, Jain N, Wong MH, Kambadur R, Thanabalu T. Insulin receptor substrate protein 53kDa (IRSp53) is a negative regulator of myogenic differentiation. Int J Biochem Cell Biol 2012; 44:928-41; PMID:22465711; http://dx.doi.org/10.1016/j.biocel.2012.02.020
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 928-941
    • Misra, A.1    George, B.2    Rajmohan, R.3    Jain, N.4    Wong, M.H.5    Kambadur, R.6    Thanabalu, T.7
  • 54
    • 77956879326 scopus 로고    scopus 로고
    • The mammalian verprolin, WIRE induces filopodia independent of N-WASP through IRSp53
    • PMID:20678498
    • Misra A, Rajmohan R, Lim RP, Bhattacharyya S, Thanabalu T. The mammalian verprolin, WIRE induces filopodia independent of N-WASP through IRSp53. Exp Cell Res 2010; 316:2810-24; PMID:20678498; http://dx.doi.org/10.1016/j. yexcr.2010.07.015
    • (2010) Exp Cell Res , vol.316 , pp. 2810-2824
    • Misra, A.1    Rajmohan, R.2    Lim, R.P.3    Bhattacharyya, S.4    Thanabalu, T.5
  • 55
    • 0034192223 scopus 로고    scopus 로고
    • Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis
    • PMID:10779443
    • Lorenzi R, Brickell PM, Katz DR, Kinnon C, Thrasher AJ. Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis. Blood 2000; 95:2943-6; PMID:10779443
    • (2000) Blood , vol.95 , pp. 2943-2946
    • Lorenzi, R.1    Brickell, P.M.2    Katz, D.R.3    Kinnon, C.4    Thrasher, A.J.5
  • 56
    • 0035871703 scopus 로고    scopus 로고
    • Cutting edge: The Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells
    • PMID:11290758
    • Leverrier Y, Lorenzi R, Blundell MP, Brickell P, Kinnon C, Ridley AJ, Thrasher AJ. Cutting edge: the Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells. J Immunol 2001; 166:4831-4; PMID:11290758; http://dx.doi.org/10.4049/jimmunol.166.8.4831
    • (2001) J Immunol , vol.166 , pp. 4831-4834
    • Leverrier, Y.1    Lorenzi, R.2    Blundell, M.P.3    Brickell, P.4    Kinnon, C.5    Ridley, A.J.6    Thrasher, A.J.7
  • 57
    • 70350554308 scopus 로고    scopus 로고
    • Characterization of Wiskott-Aldrich syndrome (WAS) mutants using Saccharomyces cerevisiae
    • PMID:19817875
    • Rajmohan R, Raodah A, Wong MH, Thanabalu T. Characterization of Wiskott-Aldrich syndrome (WAS) mutants using Saccharomyces cerevisiae. FEMS Yeast Res 2009; 9:1226-35; PMID:19817875; http://dx.doi.org/10.1111/j.1567-1364.2009.00581.x
    • (2009) FEMS Yeast Res , vol.9 , pp. 1226-1235
    • Rajmohan, R.1    Raodah, A.2    Wong, M.H.3    Thanabalu, T.4
  • 58
    • 33344457987 scopus 로고    scopus 로고
    • WASP suppresses the growth defect of Saccharomyces cerevisiae las17Delta strain in the presence of WIP
    • PMID:16488394
    • Rajmohan R, Meng L, Yu S, Thanabalu T. WASP suppresses the growth defect of Saccharomyces cerevisiae las17Delta strain in the presence of WIP. Biochem Biophys Res Commun 2006; 342:529-36; PMID:16488394; http://dx.doi.org/10.1016/j. bbrc.2006.01.160
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 529-536
    • Rajmohan, R.1    Meng, L.2    Yu, S.3    Thanabalu, T.4
  • 59
    • 84883222946 scopus 로고    scopus 로고
    • Hijacking of Rho GTPases during bacterial infection
    • PMID:23648569
    • Lemichez E, Aktories K. Hijacking of Rho GTPases during bacterial infection. Exp Cell Res 2013; 319:2329-36; PMID:23648569; http://dx.doi.org/10.1016/j.yexcr.2013.04.021
    • (2013) Exp Cell Res , vol.319 , pp. 2329-2336
    • Lemichez, E.1    Aktories, K.2
  • 60
    • 65449115788 scopus 로고    scopus 로고
    • Targeting of immune signalling networks by bacterial pathogens
    • PMID:19404331
    • Brodsky IE, Medzhitov R. Targeting of immune signalling networks by bacterial pathogens. Nat Cell Biol 2009; 11:521-6; PMID:19404331; http://dx.doi.org/10.1038/ncb0509-521
    • (2009) Nat Cell Biol , vol.11 , pp. 521-526
    • Brodsky, I.E.1    Medzhitov, R.2
  • 61
    • 0031026828 scopus 로고    scopus 로고
    • The Yersinia Yop virulon: A bacterial system for subverting eukaryotic cells
    • PMID:9076724
    • Cornelis GR, Wolf-Watz H. The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells. Mol Microbiol 1997; 23:861-7; PMID:9076724; http://dx.doi.org/10.1046/j.1365-2958.1997.2731623.x
    • (1997) Mol Microbiol , vol.23 , pp. 861-867
    • Cornelis, G.R.1    Wolf-Watz, H.2
  • 62
    • 0033861270 scopus 로고    scopus 로고
    • The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence
    • PMID:10931345
    • Black DS, Bliska JB. The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence. Mol Microbiol 2000; 37:515-27; PMID:10931345; http://dx.doi.org/10.1046/j.1365-2958.2000.02021.x
    • (2000) Mol Microbiol , vol.37 , pp. 515-527
    • Black, D.S.1    Bliska, J.B.2
  • 63
    • 2642515740 scopus 로고    scopus 로고
    • Disruption of the actin cytoskeleton results in nuclear factor-kappaB activation and inflammatory mediator production in cultured human intestinal epithelial cells
    • PMID:15137059
    • Németh ZH, Deitch EA, Davidson MT, Szabó C, Vizi ES, Haskó G. Disruption of the actin cytoskeleton results in nuclear factor-kappaB activation and inflammatory mediator production in cultured human intestinal epithelial cells. J Cell Physiol 2004; 200:71-81; PMID:15137059; http://dx.doi.org/10.1002/jcp.10477
    • (2004) J Cell Physiol , vol.200 , pp. 71-81
    • Németh, Z.H.1    Deitch, E.A.2    Davidson, M.T.3    Szabó, C.4    Vizi, E.S.5    Haskó, G.6
  • 65
    • 0032577563 scopus 로고    scopus 로고
    • S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells
    • PMID:9630225
    • Hardt WD, Chen LM, Schuebel KE, Bustelo XR, Galán JES. S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Cell 1998; 93:815-26; PMID:9630225; http://dx.doi.org/10.1016/S0092-8674(00)81442-7
    • (1998) Cell , vol.93 , pp. 815-826
    • Hardt, W.D.1    Chen, L.M.2    Schuebel, K.E.3    Bustelo, X.R.4    Galán, E.S.5
  • 66
    • 0032909858 scopus 로고    scopus 로고
    • Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1: Activation of c-Jun N-terminal kinase in HeLa cells
    • PMID:9916051
    • Lerm M, Selzer J, Hoffmeyer A, Rapp UR, Aktories K, Schmidt G. Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1: activation of c-Jun N-terminal kinase in HeLa cells. Infect Immun 1999; 67:496-503; PMID:9916051
    • (1999) Infect Immun , vol.67 , pp. 496-503
    • Lerm, M.1    Selzer, J.2    Hoffmeyer, A.3    Rapp, U.R.4    Aktories, K.5    Schmidt, G.6
  • 67
    • 34547852267 scopus 로고    scopus 로고
    • Rho GTPase-activating bacterial toxins: From bacterial virulence regulation to eukaryotic cell biology
    • PMID:17680807
    • Lemonnier M, Landraud L, Lemichez E. Rho GTPase-activating bacterial toxins: from bacterial virulence regulation to eukaryotic cell biology. FEMS Microbiol Rev 2007; 31:515-34; PMID:17680807; http://dx.doi.org/10.1111/j.1574-6976.2007.00078.x
    • (2007) FEMS Microbiol Rev , vol.31 , pp. 515-534
    • Lemonnier, M.1    Landraud, L.2    Lemichez, E.3
  • 68
    • 0031306875 scopus 로고    scopus 로고
    • Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells
    • PMID:9548496
    • Hobbie S, Chen LM, Davis RJ, Galán JE. Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells. J Immunol 1997; 159:5550-9; PMID:9548496
    • (1997) J Immunol , vol.159 , pp. 5550-5559
    • Hobbie, S.1    Chen, L.M.2    Davis, R.J.3    Galán, J.E.4
  • 69
    • 9244241054 scopus 로고    scopus 로고
    • Pore-forming protein toxins: From structure to function
    • PMID:15561302
    • Parker MW, Feil SC. Pore-forming protein toxins: from structure to function. Prog Biophys Mol Biol 2005; 88:91-142; PMID:15561302; http://dx.doi.org/10.1016/j.pbiomolbio.2004.01.009
    • (2005) Prog Biophys Mol Biol , vol.88 , pp. 91-142
    • Parker, M.W.1    Feil, S.C.2
  • 70
    • 33846829776 scopus 로고    scopus 로고
    • Pore-forming toxins and cellular non-immune defenses (CNIDs)
    • PMID:17234446
    • Aroian R, van der Goot FG. Pore-forming toxins and cellular non-immune defenses (CNIDs). Curr Opin Microbiol 2007; 10:57-61; PMID:17234446; http://dx.doi.org/10.1016/j.mib.2006.12.008
    • (2007) Curr Opin Microbiol , vol.10 , pp. 57-61
    • Aroian, R.1    Van Der Goot, F.G.2
  • 71
    • 34548699677 scopus 로고    scopus 로고
    • The role of the inflammasome in cellular responses to toxins and bacterial effectors
    • PMID:17805541
    • Freche B, Reig N, van der Goot FG. The role of the inflammasome in cellular responses to toxins and bacterial effectors. Semin Immunopathol 2007; 29:249-60; PMID:17805541; http://dx.doi.org/10.1007/s00281-007-0085-0
    • (2007) Semin Immunopathol , vol.29 , pp. 249-260
    • Freche, B.1    Reig, N.2    Van Der Goot, F.G.3
  • 72
    • 33744959839 scopus 로고    scopus 로고
    • Epithelial cells are sensitive detectors of bacterial pore-forming toxins
    • PMID:16520379
    • Ratner AJ, Hippe KR, Aguilar JL, Bender MH, Nelson AL, Weiser JN. Epithelial cells are sensitive detectors of bacterial pore-forming toxins. J Biol Chem 2006; 281:12994-8; PMID:16520379; http://dx.doi.org/10.1074/jbc.M511431200
    • (2006) J Biol Chem , vol.281 , pp. 12994-12998
    • Ratner, A.J.1    Hippe, K.R.2    Aguilar, J.L.3    Bender, M.H.4    Nelson, A.L.5    Weiser, J.N.6
  • 74
    • 0344824647 scopus 로고    scopus 로고
    • Plasma membrane disruption: Repair, prevention, adaptation
    • PMID:14570587
    • McNeil PL, Steinhardt RA. Plasma membrane disruption: repair, prevention, adaptation. Annu Rev Cell Dev Biol 2003; 19:697-731; PMID:14570587; http://dx.doi.org/10.1146/annurev.cellbio.19.111301.140101
    • (2003) Annu Rev Cell Dev Biol , vol.19 , pp. 697-731
    • McNeil, P.L.1    Steinhardt, R.A.2
  • 75
    • 0343851602 scopus 로고    scopus 로고
    • Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade
    • PMID:10627507
    • Kotzka J, Müller-Wieland D, Roth G, Kremer L, Munck M, Schürmann S, Knebel B, Krone W. Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade. J Lipid Res 2000; 41:99-108; PMID:10627507
    • (2000) J Lipid Res , vol.41 , pp. 99-108
    • Kotzka, J.1    Müller-Wieland, D.2    Roth, G.3    Kremer, L.4    Munck, M.5    Schürmann, S.6    Knebel, B.7    Krone, W.8
  • 76
    • 40849118150 scopus 로고    scopus 로고
    • Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis
    • PMID:18316410
    • Idone V, Tam C, Goss JW, Toomre D, Pypaert M, Andrews NW. Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis. J Cell Biol 2008; 180:905-14; PMID:18316410; http://dx.doi.org/10.1083/jcb.200708010
    • (2008) J Cell Biol , vol.180 , pp. 905-914
    • Idone, V.1    Tam, C.2    Goss, J.W.3    Toomre, D.4    Pypaert, M.5    Andrews, N.W.6
  • 77
    • 11844262784 scopus 로고    scopus 로고
    • O and other gram-positive cytolysins are toll-like receptor 4 agonists
    • PMID:15611291
    • Park JM, Ng VH, Maeda S, Rest RF, Karin M. Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med 2004; 200:1647-55; PMID:15611291; http://dx.doi.org/10.1084/jem.20041215
    • (2004) J Exp Med , vol.200 , pp. 1647-1655
    • Park, J.M.1    Ng, V.H.2    Maeda, S.3    Rest, R.F.4    Anthrolysin, K.M.5
  • 78
    • 44349190402 scopus 로고    scopus 로고
    • Functional and phylogenetic characterization of Vaginolysin, the human-specific cytolysin from Gardnerella vaginalis
    • PMID:18390664
    • Gelber SE, Aguilar JL, Lewis KL, Ratner AJ. Functional and phylogenetic characterization of Vaginolysin, the human-specific cytolysin from Gardnerella vaginalis. J Bacteriol 2008; 190:3896-903; PMID:18390664; http://dx.doi.org/10.1128/JB.01965-07
    • (2008) J Bacteriol , vol.190 , pp. 3896-3903
    • Gelber, S.E.1    Aguilar, J.L.2    Lewis, K.L.3    Ratner, A.J.4
  • 79
    • 84876847534 scopus 로고    scopus 로고
    • Pneumolysin-mediated expression of β-defensin 2 is coordinated by p38 MAP kinase-MKP1 in human airway cells
    • PMID:23625220
    • Kim YJ, Shin HS, Lee JH, Jung YW, Kim HB, Ha UH. Pneumolysin-mediated expression of β-defensin 2 is coordinated by p38 MAP kinase-MKP1 in human airway cells. J Microbiol 2013; 51:194-9; PMID:23625220; http://dx.doi.org/10.1007/s12275-013-2579-x
    • (2013) J Microbiol , vol.51 , pp. 194-199
    • Kim, Y.J.1    Shin, H.S.2    Lee, J.H.3    Jung, Y.W.4    Kim, H.B.5    Ha, U.H.6
  • 80
    • 0242349673 scopus 로고    scopus 로고
    • The streptococcal exotoxin streptolysin O activates mast cells to produce tumor necrosis factor alpha by p38 mitogen-activated protein kinase-and protein kinase C-dependent pathways
    • PMID:14573633
    • Stassen M, Müller C, Richter C, Neudörfl C, Hültner L, Bhakdi S, Walev I, Schmitt E. The streptococcal exotoxin streptolysin O activates mast cells to produce tumor necrosis factor alpha by p38 mitogen-activated protein kinase-and protein kinase C-dependent pathways. Infect Immun 2003; 71:6171-7; PMID:14573633; http://dx.doi.org/10.1128/IAI.71.11.6171-6177.2003
    • (2003) Infect Immun , vol.71 , pp. 6171-6177
    • Stassen, M.1    Müller, C.2    Richter, C.3    Neudörfl, C.4    Hültner, L.5    Bhakdi, S.6    Walev, I.7    Schmitt, E.8


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