The effect of hemin-induced oxidative stress on erythropoietin production in HepG2 cells

Cell Biology International

Volumn 38, Issue 11, 2014, Pages 1321-1329

  Nishimura, Kazuhiko ^a   Tokida, Masahiro ^a   Katsuyama, Hideaki ^a   Nakagawa, Hiroshi ^a   Matsuo, Saburo ^a  

^a Osaka Prefecture University   (Japan)

Author keywords

Erythropoietin production; Iron; Oxidative stress

Indexed keywords

DEFEROXAMINE; ERYTHROPOIETIN; HEMIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MALONALDEHYDE; PROTOPORPHYRIN; SUPEROXIDE DISMUTASE; TEMPOL; AMINE OXIDE; ANTIOXIDANT; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; SPIN LABELING;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HEPG2 CELL LINE; OXIDATIVE STRESS; PEROXIDATION; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; SPIN LABELING; UPREGULATION;

ANTIOXIDANTS; CYCLIC N-OXIDES; ERYTHROPOIETIN; HEMIN; HEP G2 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; MALONDIALDEHYDE; OXIDATIVE STRESS; RNA, MESSENGER; SPIN LABELS; SUPEROXIDE DISMUTASE; UP-REGULATION;

EID: 84908228360     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10329     Document Type: Article

References (41)

1. Canbolat O, Fandrey J, Jelkmann W (1998) Effects of modulators of the production and degradation of hydrogen peroxide on erythropoietin synthesis. Respir Physiol 114: 175-83.
2. Chateauvieux S, Grigorakaki C, Morceau F, Dicato M, Diederich M (2011) Erythropoietin, erythropoiesis and beyond. Biochem Pharmacol 82: 1291-303.
3. Chong ZZ, Li F, Maiese K (2005) Erythropoietin requires NFkappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity. Curr Neurovasc Res 2: 387-99.
4. Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, Gerard RD, Garcia JA (2009) Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 324: 1289-93.
5. Dongiovanni P, Valenti L, Ludovica Fracanzani A, Gatti S, Cairo G, Fargion S (2008) Iron depletion by deferoxamine upregulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. Am J Pathol 172: 738-47.
6. Haase VH (2010) Hypoxic regulation of erythropoiesis and iron metabolism. Am J Physiol Renal Physiol 299: F1-13.
7. Jelkmann W (2011) Regulation of erythropoietin production. J Physiol 589: 1251-8.
8. Jin WS, Kong ZL, Shen ZF, Jin YZ, Zhang WK, Chen GF (2011) Regulation of hypoxia inducible factor-1a expression by the alteration of redox status in HepG2 cells. J Exp Clin Cancer Res 30: 61-70.
9. Jomova K, Valko M (2011) Importance of iron chelation in free radical-induced oxidative stress and human disease. Curr Pharm Des 17: 3460-73.
10. Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, Epstein JA, Moores SL, Erickson-Miller CL, Haase VH (2010) Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood 116: 3039-48.
11. Katavetin P, Tungsanga K, Eiam-Ong S, Nangaku M (2007) Antioxidative effects of erythropoietin. Kidney Int Suppl 107:S10-15.
12. Krantz SB (1991) Erythropoietin Blood 77: 419-34.
13. Kuo MT (2009) Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 11: 99-133.
14. Lacombe C, Mayeux P (1998) Biology of erythropoietin. Haematologica 83: 724-32.
15. Lee KH, Choi E, Chun YS, Kim MS, Park JW (2006) Differential responses of two degradation domains of HIF-1alpha to hypoxia and iron deficiency. Biochimie 88: 163-9.
16. Lee JM, Lee WH, Kay HY, Kim ES, Moon A, Kim SG (2012) Hemin, an iron-binding porphyrin, inhibits HIF-1a induction through its binding with heat shock protein 90. Int J Cancer 130: 716-27.
17. Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW (2010) Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell 38:864-78.
18. Li N, Yi F, Sundy CM, Chen L, Hilliker ML, Donley DK, Muldoon DB, Li PL (2007a) Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. Am J Physiol Renal Physiol 292:F207-16.
19. Li Y, Lu Z, Keogh CL, Yu SP, Wei L (2007b) Erythropoietininduced neurovascular protection, angiogenesis, and cerebral blood flow restoration after focal ischemia in mice. J Cereb Blood Flow Metab 27: 1043-54.
20. McCaffrey TA, Pomerantz KB, Sanborn TA, Spokojny AM, Du B, Park MH, Folk JE, Lamberg A, Kivirikko KI, Falcone DJ, Mehta SB, Hanauske-Abeil HM (1995) Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries. J Clin Invest 95:446-55.
21. Maiese K, Chong ZZ, Hou J, Shang YC (2008) Erythropoietin and oxidative stress. Curr Neurovasc Res 5: 125-42.
22. Masugi F, Nakamura T (1977) Measurement of thiobarbituric acid value in liver homogenate solubilized with sodium dodecylsulphate and variation of the values affected by vitamin E and drugs. Vitamins (Japan) 51: 21-9.
23. Neumcke I, Schneider B, Fandrey J, Pagel H (1999) Effects of proand antioxidative compounds on renal production of erythropoietin. Endocrinol 140: 641-5.
24. Olson N, van der Vliet A (2011) Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease. Nitric Oxide 25: 125-37.
25. Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S (2006) Suppression of hepcidin during anemia requires erythropoietic activity. Blood 108: 3730-5.
26. Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS (2007) Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest 117: 1926-32.
27. Ramadori P, Sheikh N, Ahmad G, Dudas J, Ramadori G (2010) Hepatic changes of erythropoietin gene expression in a rat model of acute-phase response. Liver Int 30: 55-64.
28. Schmeding M, Boas-Knoop S, Lippert S, Ruehl M, Somasundaram R, Dagdelen T, Neuhaus P, Neumann UP (2008) Erythropoietin promotes hepatic regeneration after extended liver resection in rats. J Gastroenterol Hepatol 23: 1125-31.
29. Semenza GL (2011) Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim Biophys Acta 1813: 1263-8.
30. Siddiq A, Aminova LR, Ratan RR (2007) Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress. Neurochem Res 32: 931-46.
31. Stockmann C, Fandrey J (2006) Hypoxia-induced erythropoietin production: a paradigm for oxygen-regulated gene expression. Clin Exp Pharmacol Physiol 33: 968-79.
32. Szenajch J, Wcislo G, Jeong JY, Szczylik C, Feldman L (2010) The role of erythropoietin and its receptor in growth, survival and therapeutic response of human tumor cells from clinic to bench-a critical review. Biochim Biophys Acta 1806: 82-95.
33. Tajima H, Tsuchiya K, Yamada M, Kondo K, Katsube N, Ishitani R (1999) Over-expression of GAPDH induces apoptosis in COS-7 cells transfected with cloned GAPDH cDNAs. Neuroreport 10: 2029-33.
34. Takahashi-Makise N, Ward DM, Kaplan J (2012) On the mechanism of iron sensing by IR P2: new players, new paradigms. Nature Chem Biol 5: 874-5.
35. Tang WH, Wu S, Wong TM, Chung SK, Chung SS (2008) Polyol pathway mediates iron-induced oxidative injury in ischemicreperfused rat heart. Free Radic Biol Med 45: 602-10.
36. Taylor CT (2008) Mitochondria and cellular oxygen sensing in the HIF pathway. Biochem J 409: 19-26.
37. Tian H, McKnight SL, Russell DW (1997) Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 11: 72-8.
38. Toyokuni S, Uchida K, Okamoto K, Hattori-Nakakuki Y, Hiai H, Stadtman ER (1994) Formation of 4-hydroxy-2-nonenalmodified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc Natl Acad Sci USA 91: 2616-20.
39. Watkins PC, Eddy R, Hoffman N, Stanislovitis P, Beck AK, Galli J, Vellucci V, Gusella JF, Shows TB (1986) Regional assignment of the erythropoietin gene to human chromosome region 7pter-q22 Cytogenet. Cell Genet 42: 214-8.
40. Webb JD, Coleman ML, Pugh CW (2009) Hypoxia, hypoxiainducible factors (HIF), HIF hydroxylases and oxygen sensing. Cell Mol Life Sci 66: 3539-54.
41. Yeo EJ, Cho YS, Kim MS, Park JW (2008) Contribution of HIF-1alpha or HIF-2alpha to erythropoietin expression: in vivo evidence based on chromatin immunoprecipitation. Ann Hematol 87: 11-7.