Hexachlorobenzene induces TGF-β1 expression, which is a regulator of p27 and cyclin D1 modifications

Toxicology Letters

Volumn 230, Issue 1, 2014, Pages 1-9

  Chiappini, Florencia ^a   Pontillo, Carolina ^a   Randi, Andrea ^a   Alvarez, Laura ^a   Kleiman de Pisarev, Diana L ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Cell cycle; Cyclin D1; ERK1 2; FRTL 5 cells; Hexachlorobenzene; p27; TGF 1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIN D1; HEXACHLOROBENZENE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P27; TRANSFORMING GROWTH FACTOR BETA1; CCND1 PROTEIN, RAT; CDKN1B PROTEIN, RAT; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MAPK1 PROTEIN, RAT; PESTICIDE; SMAD PROTEIN; TGFB1 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; M PHASE CELL CYCLE CHECKPOINT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; RAT; SIGNAL TRANSDUCTION; THYROID CELL; THYROID FOLLICULAR CELL; ANIMAL; CELL CYCLE; CELL CYCLE G0 PHASE; CELL LINE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECT; ERK1/2; FRTL-5 CELLS; GENETICS; METABOLISM; P27; PATHOLOGY; TGF-Β1; THYROID GLAND; TIME; UPREGULATION;

CELL CYCLE; CYCLIN D1; ERK1/2; FRTL-5 CELLS; HEXACHLOROBENZENE; P27; TGF-Β1;

ANIMALS; CELL LINE; CELL SURVIVAL; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOSE-RESPONSE RELATIONSHIP, DRUG; G0 PHASE; G1 PHASE CELL CYCLE CHECKPOINTS; G2 PHASE CELL CYCLE CHECKPOINTS; HEXACHLOROBENZENE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PESTICIDES; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD PROTEINS; THYROID GLAND; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84908223789     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.08.002     Document Type: Article

References (28)

1. Agency for Toxic Substances, Disease Registry (ATSDR), Toxicological Profile for Hexachlorobenzene. 2002, U.S.D.O.H.A.H. Services, Atlanta, CA.
2. Bates, S., Parry, D., Bonetta, L., Vousden, K., Dickson, C., Peters, G., Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein. Oncogene 9 (1994), 1633–1640.
3. Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976), 248–254.
4. Carneiro, C., Alvarez, C.V., Zalvide, J., Vidal, A., Dominguez, F., TGF-β1 actions on FRTL-5 cells provide a model for the physiological regulation of thyroid growth. Oncogene 16 (1998), 1455–1465.
5. Chatani, Y., Tanimura, S., Miyoshi, N., Hattori, A., Sato, M., Kohno, M., Cell type-specific modulation of cell growth by transforming growth factor beta 1 does not correlate with mitogen-activated protein kinase activation. J. Biol. Chem. 270 (1995), 30686–30692.
6. Chiappini, F., Alvarez, L., Lux-Lantos, V., Randi, A.S., Kleiman de Pisarev, D.L., Hexachlorobenzene triggers apoptosis in rat thyroid follicular cells. Toxicol. Sci. 108 (2009), 301–310.
7. Chiappini, F., Pontillo, C., Randi, A.S., Alvarez, L., Kleiman de Pisarev, D.L., Reactive oxygen species and extracellular signal-regulated kinase 1/2 mediate hexachlorobenzene-induced cell death in FRTL-5 rat thyroid cells. Toxicol. Sci. 134 (2013), 276–290.
8. Depoortere, F., Pirson, I., Bartek, J., Dumont, J.E., Roger, P.P., Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1). Mol. Biol. Cell 11 (2000), 1061–1076.
9. Dietrich, C., Kaina, B., The AhR in the regulation of cell-cell contact and tumor growth. Carcinogenesis 31 (2010), 1319–1328.
10. Drukteinis, J.S., Medrano, T., Ablordeppey, E.A., Kitzman, J.M., Shiverick, K.T., Benzo[a]pyrene, but not 2,3,7,8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: a distinct signaling pathway. Placenta 26 (2005), S87–S95.
11. Grimalt, J.O., Sunyer, J., Moreno, V., Amaral, O.C., Sala, M., Rosell, A., Anto, J.M., Albaiges, J., Risk excess of soft-tissue sarcoma and thyroid cancer in a community exposed to airborne organochlorinated compound mixtures with a high hexachlorobenzene content. Int. J. Cancer 56 (1994), 200–203.
12. Hashimoto, O., Ueno, T., Kimura, R., Ohtsubo, M., Nakamura, T., Koga, H., Torimura, T., Uchida, S., Yamashita, K., Sata, M., Inhibition of proteasome-dependent degradation of Wee1 in G2-arrested Hep3B cells by TGF beta 1. Mol. Carcinog. 36 (2003), 171–182.
13. Jin, D.Q., Jung, J.W., Lee, Y.S., Kim, J.A., 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits cell proliferation through arylhydrocarbon receptor-mediated G1 arrest in SK-N-SH human neuronal cells. Neurosci. Lett. 363 (2004), 69–72.
14. Kato, J.Y., Matsuoka, M., Polyak, K., Massague, J., Sherr, C.J., Cyclic AMP induced G 1 phase arrest mediated by an inhibitor (p27 KIP1) of cyclin dependent kinase 4 activation. Cell 79 (1994), 487–496.
15. Knobel, M., Medeiros-Neto, G., Relevance of iodine intake as a reputed predisposing factor for thyroid cancer. Arq. Bras. Endocrinol. Metabol. 51 (2007), 701–712.
16. Massague, J., Blain, S.W., Lo, R.S., TGF beta signaling in growth control cancer and heritable disorders. Cell 103 (2000), 295–309.
17. Masamha, C.P., Benbrook, D.M., Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells. Cancer Res. 69 (2009), 6565–6572.
18. Meeker, J.D., Altshul, L., Hauser, R., Serum PCBs p,p′-DDE and HCB predict thyroid hormone levels in men. Environ Res. 104 (2007), 296–304.
19. Mincione, G., Di Marcantonio, M.C., Chiara Tarantelli Ch Sonia D'Inzeo, S., Arianna Nicolussi, A., Francesco Nardi, F., Caterina Francesca Donini, C.F., Coppa, A., EGF and TGF-1 effects on thyroid function. Review article. J. Thyroid Res., 2011, 2011 Article ID 431718, 13 pages.
20. Miyoshi, N., Uchida, K., Osawa, T., Nakamura, Y., A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation. Cancer Res. 64 (2004), 2134–2142.
21. Polyak, K., Kato, J.Y., Solomon, M.J., Sherr, C.J., Massague, J., Roberts, J.M., Koff, A., p27-KIP1, a cyclin Cdk inhibitor, links transforming growth factor beta and contact inhibition to cell cycle arrest. Genes Dev. 8 (1994), 9–22.
22. Sauer, H., Wartenberg, M., Hescheler, J., Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell. Physiol. Biochem. 11 (2001), 173–186.
23. Susaki, E., Nakayama, K.I., Multiple mechanisms for p27(Kip1) translocation and degradation. Cell Cycle 6 (2007), 3015–3020.
24. To-Figueras, J., Sala, M., Otero, R., Barrot, C., Santiago-Silva, M., Rodamilans, M., Herrero, C., Grimalt, J., Sunyer, J., Metabolism of hexachlorobenzene in humans: association between serum levels and urinary metabolites in a highly exposed population. Environ. Health Perspect. 105 (1997), 78–83.
25. van Birgelen, A.P., Hexachlorobenzene as a possible major contributor to the dioxin activity of human milk. Environ. Health Perspect. 106 (1998), 683–688 Review.
26. Venkatesha, V.A., Kalen, A.L., Sarsour, E.H., Goswam, P.C., PCB-153 exposure coordinates cell cycle progression and cellular metabolism in human mammary epithelial cells. Toxicol. Lett. 196 (2010), 110–116.
27. Vermeulen, K., Berneman, Z.N., Van Bockstaele, D.R., Cell cycle and apoptosis. Cell Prolif. 36 (2003), 165–175.
28. Zhang, Y.E., Non-Smad pathways in TGF-β signaling. Cell Res. 19 (2009), 128–139.