The PI3K/p-Akt signaling pathway participates in calcitriol ameliorating podocyte injury in DN rats

Metabolism: Clinical and Experimental

Volumn 63, Issue 10, 2014, Pages 1324-1333

  Song, Zhixia ^a   Guo, Yinfeng ^a   Zhou, Min ^a   Zhang, Xiaoliang ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

Calcitriol; Diabetic nephropathy; PI3K p Akt signaling pathway; Podocyte

Indexed keywords

CALCITRIOL; COLECALCIFEROL; CREATININE; DESMIN; NEPHRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHORUS; PODOCIN; PROTEIN KINASE B; PROTEIN P85; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; MEMBRANE PROTEIN;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GLUCOSE MONITORING; BODY WEIGHT; CALCIUM BLOOD LEVEL; CELL DAMAGE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY PARENCHYMA; MALE; NONHUMAN; PHOSPHATE BLOOD LEVEL; PODOCYTE; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UREA NITROGEN BLOOD LEVEL; URINALYSIS; URINARY EXCRETION; ANIMAL; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; PHYSIOLOGY; PI3K/P-AKT SIGNALING PATHWAY; SPRAGUE DAWLEY RAT;

CALCITRIOL; DIABETIC NEPHROPATHY; PI3K/P-AKT SIGNALING PATHWAY; PODOCYTE;

ALBUMINURIA; ANIMALS; CALCITRIOL; DESMIN; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; MALE; MEMBRANE PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; PODOCYTES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CALCITRIOL; SIGNAL TRANSDUCTION;

EID: 84908223067     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.06.013     Document Type: Article

References (38)

1. Y. Xu Prevalence and control of diabetes in Chinese adults JAMA 310 9 2013 948 959
2. Y. Xu Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy Metabolism 63 5 2014 716 726
3. J.A. Jefferson, S.J. Shankland, and R.H. Pichler Proteinuria in diabetic kidney disease: a mechanistic viewpoint Kidney Int 74 1 2008 22 36
4. S.J. Allison Podocyte biology: a new regulator of podocytes Nat Rev Nephrol 8 12 2012 683
5. J. Reiser The glomerular slit diaphragm is a modified adherens junction J Am Soc Nephrol 11 1 2000 1 8
6. K. Tryggvason Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm J Am Soc Nephrol 10 11 1999 2440 2445
7. M. Kestila Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome Mol Cell 1 4 1998 575 582
8. J. Khoshnoodi Nephrin promotes cell-cell adhesion through homophilic interactions Am J Pathol 163 6 2003 2337 2346
9. G.I. Welsh, and M.A. Saleem Nephrin-signature molecule of the glomerular podocyte? J Pathol 220 3 2010 328 337
10. H. Li SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin J Am Soc Nephrol 15 12 2004 3006 3015
11. T.B. Huber Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling Mol Cell Biol 23 14 2003 4917 4928
12. J. Zhu Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes Kidney Int 73 5 2008 556 566
13. L.C. Cantley The phosphoinositide 3-kinase pathway Science 296 5573 2002 1655 1657
14. X. Chen Ghrelin induces cell migration through GHSR1a-mediated PI3K/Akt/eNOS/NO signaling pathway in endothelial progenitor cells Metabolism 62 5 2013 743 752
15. S. Yu, and Y. Li Dexamethasone inhibits podocyte apoptosis by stabilizing the PI3K/Akt signal pathway Biomed Res Int 2013 2013 326986 326994
16. B. Bussolati Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the phosphatidylinositol 3-kinase/AKT-signaling pathway J Am Soc Nephrol 16 7 2005 1936 1947
17. A. Vaidya Vitamin D and cardio-metabolic disease Metabolism 62 12 2013 1697 1699
18. M.F. Holick Vitamin D deficiency N Engl J Med 357 3 2007 266 281
19. Y.C. Li Podocytes as target of vitamin D Curr Diabetes Rev 7 1 2011 35 40
20. Y.C. Li Renoprotective effects of vitamin D analogs Kidney Int 78 2 2010 134 139
21. K. Yamauchi Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocytes Kidney Int 70 5 2006 892 900
22. H. Sugimoto Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis Nat Med 18 3 2012 396 404
23. M.M. Pan Inhibition of TGF-beta1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats Food Chem Toxicol 58 2013 487 494
24. J. Silver, J. Russell, and L.M. Sherwood Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells Proc Natl Acad Sci U S A 82 12 1985 4270 4273
25. M. Teng Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy N Engl J Med 349 5 2003 446 456
26. D. de Zeeuw Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial Lancet 376 9752 2010 1543 1551
27. D.D. Bikle Vitamin D metabolism, mechanism of action, and clinical applications Chem Biol 21 3 2014 319 329
28. C.F. Helvig Dysregulation of renal vitamin D metabolism in the uremic rat Kidney Int 78 5 2010 463 472
29. G. Fernandez-Juarez 25 (OH) vitamin D levels and renal disease progression in patients with type 2 diabetic nephropathy and blockade of the renin-angiotensin system Clin J Am Soc Nephrol 8 11 2013 1870 1876
30. Y. Wang Vitamin D receptor signaling in podocytes protects against diabetic nephropathy J Am Soc Nephrol 23 12 2012 1977 1986
31. R. Sonneveld Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease Am J Pathol 182 4 2013 1196 1204
32. B.C. Liu High glucose induces podocyte apoptosis by stimulating TRPC6 via elevation of reactive oxygen species Biochim Biophys Acta 1833 6 2013 1434 1442
33. Z. Li Wnt/beta-catenin signalling pathway mediates high glucose induced cell injury through activation of TRPC6 in podocytes Cell Prolif 46 1 2013 76 85
34. A. Fornoni Proteinuria, the podocyte, and insulin resistance N Engl J Med 363 21 2010 2068 2069
35. S.M. Karle Novel mutations in NPHS2 detected in both familial and sporadic steroid-resistant nephrotic syndrome J Am Soc Nephrol 13 2 2002 388 393
36. S. Doublier Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome Am J Pathol 158 5 2001 1723 1731
37. X.M. Wang Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis Am J Physiol Renal Physiol 306 2 2014 F205 F213
38. M. Okamura Induction of nephrin gene expression by selective cooperation of the retinoic acid receptor and the vitamin D receptor Nephrol Dial Transplant 24 10 2009 3006 3012