Ghrelin induces cell migration through GHSR1a-mediated PI3K/Akt/eNOS/NO signaling pathway in endothelial progenitor cells

Metabolism: Clinical and Experimental

Volumn 62, Issue 5, 2013, Pages 743-752

  Chen, Xiaodong ^a   Chen, Qingwei ^a   Wang, Li ^a   Li, Guiqiong ^a  

^a THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

EPC; Ghrelin; GHSR; Migration

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CD133 ANTIGEN; CD34 ANTIGEN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GHRELIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PROTEIN KINASE B; VASCULOTROPIN RECEPTOR 2; VON WILLEBRAND FACTOR;

ANIMAL CELL; ARTICLE; BONE MARROW; CELL MIGRATION; DENSITY GRADIENT CENTRIFUGATION; ENDOTHELIAL PROGENITOR CELL; IMMUNOCYTOCHEMISTRY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; CELL MOVEMENT; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; ENDOTHELIAL CELLS; GHRELIN; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GHRELIN; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 84876675775     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2012.09.014     Document Type: Article

References (42)

1. F. Caiado, and S. Dias Endothelial progenitor cells and integrins: Adhesive needs Fibrogenesis Tissue Repair 5 2012 4
2. A. Ranghino, V. Cantaluppi, and C. Grange Endothelial progenitor cell-derived microvesicles improve neovascularization in a murine model of hindlimb ischemia Int J Immunopathol Pharmacol 25 2012 75 85
3. C. Jung, P. Sorensson, and N. Saleh Effects of myocardial postconditioning on the recruitment of endothelial progenitor cells J Interv Cardiol 25 2012 103 110
4. A. Petrelli, R. Di Fenza, and M. Carvello Strategies to reverse endothelial progenitor cell dysfunction in diabetes Exp Diabetes Res 2012 2012 471823
5. J. Groleau, S. Dussault, and J. Turgeon Accelerated vascular aging in CuZnSOD-deficient mice: Impact on EPC function and reparative neovascularization PLoS One 6 2011 e23308
6. J.M. Hill, G. Zalos, and J.P. Halcox Circulating endothelial progenitor cells, vascular function, and cardiovascular risk N Engl J Med 348 2003 593 600 (Pubitemid 36204953)
7. M. Kojima, H. Hosoda, and Y. Date Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660 (Pubitemid 129516334)
8. C.R. Cruz, and R.G. Smith The growth hormone secretagogue receptor Vitam Horm 77 2008 47 88
9. S. Gnanapavan, B. Kola, and S.A. Bustin The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans J Clin Endocrinol Metab 87 2002 2988
10. S. Ghelardoni, V. Carnicelli, and S. Frascarelli Ghrelin tissue distribution: comparison between gene and protein expression J Endocrinol Invest 29 2006 115 121
11. H. Kageyama, H. Funahashi, and M. Hirayama Morphological analysis of ghrelin and its receptor distribution in the rat pancreas Regul Pept 126 2005 67 71 (Pubitemid 40037745)
12. A. Yabuki, S. Taharaguchi, and O. Ichii Immunohistochemical localization of ghrelin in rodent kidneys Histochem Cell Biol 126 2006 231 238
13. M.J. Kleinz, J.J. Maguire, and J.N. Skepper Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man Cardiovasc Res 69 2006 227 235 (Pubitemid 41814824)
14. S.D. Katugampola, Z. Pallikaros, and A.P. Davenport [125I-His(9)]- ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with atherosclerosis Br J Pharmacol 134 2001 143 149 (Pubitemid 32835477)
15. M. Tesauro, F. Schinzari, and M. Caramanti Cardiovascular and metabolic effects of ghrelin Curr Diabetes Rev 6 2010 228 235
16. G. Togliatto, A. Trombetta, and P. Dentelli Unacylated ghrelin rescues endothelial progenitor cell function in individuals with type 2 diabetes Diabetes 59 2010 1016 1025
17. M. Tesauro, F. Schinzari, and M. Iantorno Ghrelin improves endothelial function in patients with metabolic syndrome Circulation 112 2005 2986 2992 (Pubitemid 41612302)
18. M.J. Yuan, C.X. Huang, and Y.H. Tang A novel peptide ghrelin inhibits neural remodeling after myocardial infarction in rats Eur J Pharmacol 618 2009 52 57
19. C. Cheyuo, R. Wu, and M. Zhou Ghrelin suppresses inflammation and neuronal nitric oxide synthase in focal cerebral ischemia via the vagus nerve Shock 35 2011 258 265
20. H. Zhao, G. Liu, and Q. Wang Effect of ghrelin on human endothelial cells apoptosis induced by high glucose Biochem Biophys Res Commun 362 2007 677 681 (Pubitemid 47368145)
21. M. Dinca, I.L. Dumitriu, and M.B. Gurzu Ghrelin and Ang 1-7 have cumulative vasodilatory effects on pulmonary vessels Rev Med Chir Soc Med Nat Iasi 114 2010 803 807
22. M. Zhang, W.Y. Fang, and F. Yuan Plasma ghrelin levels are closely associated with severity and morphology of angiographically-detected coronary atherosclerosis in Chineses patients with diabetes mellitus Acta Pharmacol Sin 33 2012 452 458
23. P.C. Konturek, T. Brzozowski, and B. Walter Ghrelin-induced gastroprotection against ischemia-reperfusion injury involves an activation of sensory afferent nerves and hyperemia mediated by nitric oxide Eur J Pharmacol 536 2006 171 181
24. T. Brzozowski, P.C. Konturek, and Z. Sliwowski Prostaglandin/ cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury J Pharmacol Exp Ther 319 2006 477 487 (Pubitemid 44455155)
25. A. Ahluwalia, A. Li, and G. Cheng Reduced ghrelin in endothelial cells plays important mechanistic role in aging-related impairment of angiogenesis J Physiol Pharmacol 60 2009 29 34
26. A. Li, G. Cheng, and G.H. Zhu Ghrelin stimulates angiogenesis in human microvascular endothelial cells: Implications beyond GH release Biochem Biophys Res Commun 353 2007 238 243 (Pubitemid 46014561)
27. M.T. Conconi, B. Nico, and D. Guidolin Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo Peptides 25 2004 2179 2185 (Pubitemid 39574461)
28. S. Baiguera, M.T. Conconi, and D. Guidolin Ghrelin inhibits in vitro angiogenic activity of rat brain microvascular endothelial cells Int J Mol Med 14 2004 849 854
29. T. Soeki, I. Kishimoto, and D.O. Schwenke Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction Am J Physiol Heart Circ Physiol 294 2008 H426 H432
30. S.J. Lee, S. Namkoong, and Y.M. Kim Fractalkine stimulates angiogenesis by activating the Raf-1/MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways Am J Physiol Heart Circ Physiol 291 2006 H2836 H2846
31. M. Ziche, and L. Morbidelli Nitric oxide and angiogenesis J Neurooncol 50 2000 139 148 (Pubitemid 32166296)
32. L. Wang, Q. Chen, and G. Li Ghrelin stimulates angiogenesis via GHSR1a-dependent MEK/ERK and PI3K/Akt signal pathways in rat cardiac microvascular endothelial cells Peptides 33 2012 92 100
33. S. Khachi, Y. Zhu, and G.Y. Yang Preparation and analysis of endothelial progenitor cells associated with angiogenesis Methods Mol Biol 621 2010 139 148
34. H.E. Choi, M.S. Yoo, and J.H. Choi BRN-103, a novel nicotinamide derivative, inhibits VEGF-induced angiogenesis and proliferation in human umbilical vein endothelial cells Bioorg Med Chem Lett 21 2011 6236 6241
35. S. Yu, S.L. Wong, and C.W. Lau Oxidized LDL at low concentration promotes in-vitro angiogenesis and activates nitric oxide synthase through PI3K/Akt/eNOS pathway in human coronary artery endothelial cells Biochem Biophys Res Commun 407 2011 44 48
36. Y. Wang, W. Yan, and X. Lu Overexpression of osteopontin induces angiogenesis of endothelial progenitor cells via the avbeta3/PI3K/AKT/eNOS/NO signaling pathway in glioma cells Eur J Cell Biol 90 2011 642 648
37. M. Nakazato, N. Murakami, and Y. Date A role for ghrelin in the central regulation of feeding Nature 409 2001 194 198 (Pubitemid 32144284)
38. M. Tschop, D.L. Smiley, and M.L. Heiman Ghrelin induces adiposity in rodents Nature 407 2000 908 913
39. K. Zaniolo, P. Sapieha, and Z. Shao Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a Invest Ophthalmol Vis Sci 52 2011 5376 5386
40. Y. Wang, K. Narsinh, and L. Zhao Effects and mechanisms of ghrelin on cardiac microvascular endothelial cells in rats Cell Biol Int 35 2011 135 140
41. C. Urbich, C. Heeschen, and A. Aicher Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells Circulation 108 2003 2511 2516 (Pubitemid 37444414)
42. F. Rossi, C. Bertone, and S. Petricca Ghrelin inhibits angiotensin II-induced migration of human aortic endothelial cells Atherosclerosis 192 2007 291 297 (Pubitemid 46726330)