-
2
-
-
34547176642
-
Unravelling the pathogenesis of inflammatory bowel disease
-
Xavier, R. J. & Podolsky, D. K. Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427-434 (2007).
-
(2007)
Nature
, vol.448
, pp. 427-434
-
-
Xavier, R.J.1
Podolsky, D.K.2
-
3
-
-
33847381116
-
The fundamental basis of inflammatory bowel disease
-
Strober, W, Fuss, I & Mannon, P. The fundamental basis of inflammatory bowel disease. J. Clin. Invest. 117, 514-521 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 514-521
-
-
Strober Fuss W, I.1
Mannon, P.2
-
4
-
-
0142053206
-
The immunological and genetic basis of inflammatory bowel disease
-
Bouma, G & Strober, W. The immunological and genetic basis of inflammatory bowel disease. Nat. Rev. Immunol. 3, 521-533 (2003).
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 521-533
-
-
Bouma, G.1
Strober, W.2
-
5
-
-
79955563439
-
Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
-
Strober, W & Fuss, I. J. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140, 1756-1767 (2011).
-
(2011)
Gastroenterology
, vol.140
, pp. 1756-1767
-
-
Strober, W.1
Fuss, I.J.2
-
6
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai, S, Armstrong, C. M., Kaeberlein, M & Guarente, L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800 (2000).
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
7
-
-
0034705129
-
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
-
Landry, J. et al. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl Acad. Sci. USA 97, 5807-5811 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 5807-5811
-
-
Landry, J.1
-
8
-
-
4944245398
-
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
-
Vaquero, A, Scher, M, Lee, D, Erdjument-Bromage, H, Tempst, P & Reinberg, D. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 16, 93-105 (2004).
-
(2004)
Mol. Cell
, vol.16
, pp. 93-105
-
-
Vaquero, A.1
Scher, M.2
Lee, D.3
Erdjument-Bromage, H.4
Tempst, P.5
Reinberg, D.6
-
9
-
-
17144429302
-
Calorie restriction, SIRT1 and metabolism: Understanding longevity
-
Bordone, L & Guarente, L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat. Rev. Mol. Cell Biol. 6, 298-305 (2005).
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 298-305
-
-
Bordone, L.1
Guarente, L.2
-
10
-
-
2942564591
-
Sirtuins: Sir2-related NAD-dependent protein deacetylases
-
North, B. J. & Verdin, E. Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol. 5, 224 (2004).
-
(2004)
Genome Biol.
, vol.5
, pp. 224
-
-
North, B.J.1
Verdin, E.2
-
11
-
-
0032977614
-
Characterization of a human genewith sequence homology to Saccharomyces cerevisiae SIR2
-
Afshar,G& Murnane, J. P. Characterization of a human genewith sequence homology to Saccharomyces cerevisiae SIR2. Gene 234, 161-168 (1999).
-
(1999)
Gene
, vol.234
, pp. 161-168
-
-
Afshar, G.1
Murnane, J.P.2
-
12
-
-
70349440053
-
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
-
Zhang, J. et al. The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. J. Clin. Invest. 119, 3048-3058 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3048-3058
-
-
Zhang, J.1
-
13
-
-
33846976509
-
SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
-
Kume, S. et al. SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J. Biol. Chem. 282, 151-158 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 151-158
-
-
Kume, S.1
-
14
-
-
77956677458
-
Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
-
Schug, T. T. et al. Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Mol. Cell. Biol. 30, 4712-4721 (2010).
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 4712-4721
-
-
Schug, T.T.1
-
15
-
-
0031925362
-
Activation of nuclear factor kappa B inflammatory bowel disease
-
Schreiber, S, Nikolaus, S & Hampe, J. Activation of nuclear factor kappa B inflammatory bowel disease. Gut 42, 477-484 (1998).
-
(1998)
Gut
, vol.42
, pp. 477-484
-
-
Schreiber, S.1
Nikolaus, S.2
Hampe, J.3
-
16
-
-
0032437063
-
Cytokine gene transcription by NF-kappa B family members in patients with inflammatory bowel disease
-
Neurath, M. F. et al. Cytokine gene transcription by NF-kappa B family members in patients with inflammatory bowel disease. Ann. N. Y. Acad. Sci. 859, 149-159 (1998).
-
(1998)
Ann. N. Y. Acad. Sci.
, vol.859
, pp. 149-159
-
-
Neurath, M.F.1
-
17
-
-
0030209985
-
Disparate CD4 lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
-
Fuss, I. J. et al. Disparate CD4 lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157, 1261-1270 (1996).
-
(1996)
J. Immunol.
, vol.157
, pp. 1261-1270
-
-
Fuss, I.J.1
-
18
-
-
67650224449
-
Crohn's disease: Th1, Th17 or both? the change of a paradigm: New immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
-
Brand, S. Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut 58, 1152-1167 (2009).
-
(2009)
Gut
, vol.58
, pp. 1152-1167
-
-
Brand, S.1
-
19
-
-
15744390341
-
Interleukin-21 enhances T-helper cell type i signaling and interferon-gamma production in Crohn's disease
-
Monteleone, G. et al. Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology 128, 687-694 (2005).
-
(2005)
Gastroenterology
, vol.128
, pp. 687-694
-
-
Monteleone, G.1
-
20
-
-
41349121555
-
Regulation of gut inflammation and th17 cell response by interleukin-21
-
Fina, D. et al. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology 134, 1038-1048 (2008).
-
(2008)
Gastroenterology
, vol.134
, pp. 1038-1048
-
-
Fina, D.1
-
21
-
-
23244455992
-
Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
-
Heller, F. et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 129, 550-564 (2005).
-
(2005)
Gastroenterology
, vol.129
, pp. 550-564
-
-
Heller, F.1
-
22
-
-
0028861975
-
Antibodies to interleukin 12 abrogate established experimental colitis in mice
-
Neurath, M. F., Fuss, I, Kelsall, B. L., Stuber, E & Strober, W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182, 1281-1290 (1995).
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1281-1290
-
-
Neurath, M.F.1
Fuss Kelsall, I.B.L.2
Stuber, E.3
Strober, W.4
-
23
-
-
0032538915
-
Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
-
Boirivant, M, Fuss, I. J., Chu, A & Strober, W. Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J. Exp. Med. 188, 1929-1939 (1998).
-
(1998)
J. Exp. Med.
, vol.188
, pp. 1929-1939
-
-
Boirivant, I.J.1
Fuss, M.2
Chu, A.3
Strober, W.4
-
24
-
-
0036850908
-
Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
-
Heller, F, Fuss, I. J., Nieuwenhuis, E. E., Blumberg, R. S. & Strober, W. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 17, 629-638 (2002).
-
(2002)
Immunity
, vol.17
, pp. 629-638
-
-
Heller Fuss F, I.J.1
Nieuwenhuis, E.E.2
Blumberg, R.S.3
Strober, W.4
-
25
-
-
46749154270
-
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
-
Mudter, J. et al. The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J. Clin. Invest. 118, 2415-2426 (2008).
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2415-2426
-
-
Mudter, J.1
-
26
-
-
84855421642
-
Sirtuin 1 in immune regulation and autoimmunity
-
Kong, S, McBurney, M. W. & Fang, D. Sirtuin 1 in immune regulation and autoimmunity. Immunol. Cell Biol. 90, 6-13 (2012).
-
(2012)
Immunol. Cell Biol.
, vol.90
, pp. 6-13
-
-
Kong McBurney S, M.W.1
Fang, D.2
-
27
-
-
84859223555
-
Musosal tumour necrosis factor alpha in diverticular disease of the colon is overexpressed with disease severity
-
Tursi, A. et al. Musosal tumour necrosis factor alpha in diverticular disease of the colon is overexpressed with disease severity. Colorectal Dis. 14, e258-e263 (2012).
-
(2012)
Colorectal Dis.
, vol.14
, pp. e258-e263
-
-
Tursi, A.1
-
28
-
-
84891420113
-
Analysis of the cytokine profile in the duodenal mucosa of refractory coeliac disease patients
-
Caruso, R. et al. Analysis of the cytokine profile in the duodenal mucosa of refractory coeliac disease patients. Clin. Sci. (Lond) 126, 451-458 (2014).
-
(2014)
Clin. Sci. (Lond)
, vol.126
, pp. 451-458
-
-
Caruso, R.1
-
29
-
-
42649146208
-
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
-
Rajendrasozhan, S, Yang, S. R., Kinnula, V. L. & Rahman, I. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 177, 861-870 (2008).
-
(2008)
Am. J. Respir. Crit. Care Med.
, vol.177
, pp. 861-870
-
-
Rajendrasozhan, S.R.1
Yang, S.2
Kinnula, V.L.3
Rahman, I.4
-
30
-
-
84875332275
-
Identification of a SIRT1 mutation in a family with type 1 diabetes
-
Biason-Lauber, A. et al. Identification of a SIRT1 mutation in a family with type 1 diabetes. Cell Metab. 17, 448-455 (2013).
-
(2013)
Cell Metab.
, vol.17
, pp. 448-455
-
-
Biason-Lauber, A.1
-
31
-
-
33751560439
-
SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents
-
Nayagam, V. M. et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J. Biomol. Screen. 11, 959-967 (2006).
-
(2006)
J. Biomol. Screen.
, vol.11
, pp. 959-967
-
-
Nayagam, V.M.1
-
32
-
-
29144501185
-
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1
-
Napper, A. D. et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J. Med. Chem. 48, 8045-8054 (2005).
-
(2005)
J. Med. Chem.
, vol.48
, pp. 8045-8054
-
-
Napper, A.D.1
-
33
-
-
84866986715
-
SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-kappaB activity
-
Yang, H. et al. SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-kappaB activity. PLoS One 7, e46364 (2012).
-
(2012)
PLoS One
, vol.7
, pp. e46364
-
-
Yang, H.1
-
34
-
-
84877134225
-
SIRT1 activation protects against autoimmune Tcell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling
-
Gardner, P. J., Joshi, L, Lee, R. W., Dick, A. D., Adamson, P & Calder, V. L. SIRT1 activation protects against autoimmune Tcell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling. J. Autoimmun. 42, 117-129 (2013).
-
(2013)
J. Autoimmun.
, vol.42
, pp. 117-129
-
-
Gardner, P.J.1
Joshi Lee L, R.W.2
Dick, A.D.3
Adamson, P.4
Calder, V.L.5
-
35
-
-
77249089947
-
Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodiuminduced colitis
-
Singh, U. P. et al. Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodiuminduced colitis. J. Pharmacol. Exp. Ther. 332, 829-839 (2010).
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.332
, pp. 829-839
-
-
Singh, U.P.1
-
36
-
-
33646572516
-
The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model
-
Martin, A. R., Villegas, I, Sanchez-Hidalgo, M & de la Lastra, C. A. The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. Br. J. Pharmacol. 147, 873-885 (2006).
-
(2006)
Br. J. Pharmacol.
, vol.147
, pp. 873-885
-
-
Martin, A.R.1
Villegas, M.2
Sanchez-Hidalgo, I.3
De La Lastra, C.A.4
-
37
-
-
1542285473
-
Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats
-
Martin, A. R., Villegas, I, La Casa, C & de la Lastra, C. A. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochem. Pharmacol. 67, 1399-1410 (2004).
-
(2004)
Biochem. Pharmacol.
, vol.67
, pp. 1399-1410
-
-
Martin, A.R.1
Villegas, C.2
La Casa, I.3
De La Lastra, C.A.4
-
38
-
-
0036738421
-
Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation
-
Hilliard, B. A. et al. Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. J. Clin. Invest. 110, 843-850 (2002).
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 843-850
-
-
Hilliard, B.A.1
-
39
-
-
84906344581
-
Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3 T-regulatory cells
-
advance online publication 19 February (e-pub ahead of print
-
Akimova, T. et al. Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3 T-regulatory cells. Mucosal Immunol. advance online publication, 19 February 2014; doi:10. 1038/mi. 2014. 10 (2014) (e-pub ahead of print).
-
(2014)
Mucosal Immunol
-
-
Akimova, T.1
-
40
-
-
4744375545
-
Development and validation of a new, simplified endoscopic activity score for Crohn's disease: The SES-CD
-
Daperno, M. et al. Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD. Gastrointest. Endosc. 60, 505-512 (2004).
-
(2004)
Gastrointest. Endosc.
, vol.60
, pp. 505-512
-
-
Daperno, M.1
-
41
-
-
0023521441
-
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis
-
Schroeder, K. W., Tremaine, W. J. & Ilstrup, D. M. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N. Engl. J. Med. 317, 1625-1629 (1987).
-
(1987)
A Randomized Study. N. Engl. J. Med.
, vol.317
, pp. 1625-1629
-
-
Schroeder, K.W.1
Tremaine, W.J.2
Ilstrup, D.M.3
-
42
-
-
0026515461
-
Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue')
-
Marsh, M. N. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 102, 330-354 (1992).
-
(1992)
Gastroenterology
, vol.102
, pp. 330-354
-
-
Marsh, M.N.1
-
43
-
-
0030995575
-
Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
-
Monteleone, G. et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 112, 1169-1178 (1997).
-
(1997)
Gastroenterology
, vol.112
, pp. 1169-1178
-
-
Monteleone, G.1
-
44
-
-
33846248387
-
A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells
-
Caruso, R. et al. A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. Gastroenterology 132, 166-175 (2007).
-
(2007)
Gastroenterology
, vol.132
, pp. 166-175
-
-
Caruso, R.1
-
45
-
-
33845647693
-
Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis
-
Boirivant, M. et al. Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis. Gastroenterology 131, 1786-1798 (2006).
-
(2006)
Gastroenterology
, vol.131
, pp. 1786-1798
-
-
Boirivant, M.1
-
46
-
-
80055105733
-
Involvement of interleukin-21 in the regulation of colitisassociated colon cancer
-
Stolfi, C. et al. Involvement of interleukin-21 in the regulation of colitisassociated colon cancer. J. Exp. Med. 208, 2279-2290 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 2279-2290
-
-
Stolfi, C.1
|