Cytokine gene transcription by NF-κB family members in patients with inflammatory bowel disease

Annals of the New York Academy of Sciences

Volumn 859, Issue , 1998, Pages 149-159

  Neurath, Markus F ^a   Fuss, Ivan ^b   Schürmann, Guido ^c   Pettersson, Sven ^d   Arnold, Karl ^e   Müller Lobeck, Helmut ^f   Strober, Warren ^b   Herfarth, Christian ^c   Meyer Zum Büschenfelde, Karl Hermann ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d KAROLINSKA INSTITUTE   (Sweden)

^e ST JOSEFS HOSPITAL   (Germany)

^f DEUTSCHE KLINIK FÜR DIAGNOSTIK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY DNA; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 6; PHOSPHOROTHIOIC ACID DERIVATIVE; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR;

ADOLESCENT; ADULT; CONFERENCE PAPER; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; ENTERITIS; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; PROTEIN DNA BINDING; PROTEIN EXPRESSION; ULCERATIVE COLITIS;

EID: 0032437063     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb11119.x     Document Type: Conference Paper

References (29)

1. 1. MOWAT, A. M. 1987. The regulation of immune responses to dietary protein antigens. Immunol. Today 8: 93-98.
2. 2. DUCHMANN, R. et al. 1995. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin. Exp. Immunol. 102: 448-455.
3. 3. NEURATH, M. F. & K.-H. MEYER ZUM BÜSCHENFELDE. 1996. Protective and pathogenic roles of cytokines in inflammatory bowel diseases. J. Invest. Med. 44: 516-521.
4. 4. STROBER, W. & M. F. NEURATH. 1995. Immunological diseases of the gastrointestinal tract. In R. R. Rich, ed. Clinical Immunology. Chapter 94: 1401-1428. Mosby. St. Louis.
5. 5. POWRIE, F. et al. 1994. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1: 553-562.
6. 6. POWRIE, F. 1995. T cells in inflammatory bowel disease: Protective and pathogenic roles. Immunity 3: 171-174.
7. 7. VAN DULLEMEN, H. M. et al. 1995. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 109: 129-135.
8. 8. CIECHANOVER, A. 1994. The ubiquitin-proteasome proteolysis pathway. Cell 79: 13-21.
9. 9. ARSURA, M. et al. 1996. TGFb1 inhibits NF-κB/Rel activity inducing apoptosis of B cells: Transcriptional activation of IκB. Immunity 5: 31-40.
10. 10. IP, T. Y. et al. 1993. Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell 75: 753-763.
11. 11. FINCO, T. S. & A. S. BALDWIN. 1995. Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis. Immunity 3: 263-272.
12. 12. LENARDO, M. J. & D. BALTIMORE. 1989. NF-κB: a pleiotropic activator of inducible and tissue specific gene control. Cell 58: 227-237.
13. 13. BAEUERLE, P. A. & T. HENKEL. 1994. Function and activation of NF-κB in the immune system. Ann. Rev. Immunol. 12: 141-179.
14. 14. GHOSH, S. & D. BALTIMORE. 1990. Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB. Nature 344: 678-682.
15. 15. NAUMANN, M. & C. SCHEIDEREIT. 1994. Activation of NF-kB in vivo is regulated by multiple phosphorylations. EMBO J. 13: 4597-4607.
16. 16. SHA, W., et al. 1995. Targeted disruption of the p50 subunit of NF-kB leads to multifocal defects in immune responses. Cell 80: 321-330.
17. 17. WEIH, F. et al. 1995. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of Re1B, a member of the NF-κB/Rel family. Cell 80: 331-340.
18. 18. KÖNTGEN, F. et al. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9: 1965-1977.
19. 19. BULL, D. M. & M. A. BOOKMAN. 1977. Isolation and functional characterization of human intestinal mucosal mononuclear cells. J. Clin. Invest. 59: 966-974.
20. 20. EBERT, E. C. 1989. Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli. Gastroenterology 97: 1372-1381.
21. 21. Fuss, I. et al. 1996. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. J. Immunol. 157: 1261-1270.
22. 22. NEURATH, M. F., E. E. MAX & W. STROBER. 1995. Pax5 (BSAP) regulates the murine immunoglobulin 3′α enhancer by affecting binding of NF-αP, a protein that controls heavy chain transcription. Proc. Natl. Acad. Sci. USA 92: 5336-5340.
23. 23. NEURATH. M. F. et al. 1996. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-κB abrogates experimental colitis in mice. Nature Med. 2: 998-1004.
24. 24. TARGAN, S. R. et al. 1995. Definition of a lamina propria T cell responsive state. J. Immunol. 154: 664-675.
25. 25. GERONDAKIS, S. et al. 1996. Rel-deficient T cells exhibit defects in production of interleukin-3 and granulocyte-macrophage colony-stimulating factor. Proc. Natl. Acad. Sci. USA 93: 3405-3409.
26. 26. WRIGHTON, C. J., R. HOFER-WARBINEK & T. MOLL. 1996. Inhibition of endothelial cell activation by adenovirus-mediated expression of IκBα, an inhibitor of the transcription factor NF-kB. J. Exp. Med. 183: 1013-1022.
27. 27. SCHEINMAN, R. I. et al. 1995. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270: 283-286.
28. 28. AUPHAN, N. et al. 1995. Immunosuppression by glucocorticoids: Inhibition of NF-κBα activity through induction of IκBα synthesis. Science 270: 286-290.
29. 29. JOBIN, C. et al. 1997. Evidence for altered regulation of IκBα degradation in human colonic epithelial cells. J. Immunol. 158: 226-234.