Estrogen-mediated regulation of steroid metabolism in rat glial cells; Effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis

Journal of Steroid Biochemistry and Molecular Biology

Volumn 145, Issue , 2015, Pages 21-27

  Wicher, Grzegorz ^a   Norlin, Maria ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Astrocytes; Nervous system; Neurosteroid metabolism; Schwann cells; Sex hormone

Indexed keywords

26 HYDROXYCHOLESTEROL; CYTOCHROME P450; CYTOCHROME P450 7B1; ESTRADIOL; ESTROGEN; NEUROSTEROID; PRASTERONE; PREGNENOLONE; PROGESTERONE; SEX HORMONE; UNCLASSIFIED DRUG; 27-HYDROXYCHOLESTEROL; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANDROSTANE DERIVATIVE; ANDROSTENEDIONE; CHOLESTEROL DERIVATIVE; CULTURE MEDIUM; CYP7B1 PROTEIN, RAT; PRASTERONE SULFATE; STEROID; STEROID MONOOXYGENASE;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN; CATALYSIS; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESTROGEN ACTIVITY; GLIA CELL; HORMONAL REGULATION; NERVOUS SYSTEM; NEWBORN; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; RAT; SCHWANN CELL; SCIATIC NERVE; STEROID METABOLISM; ANIMAL; CELL CULTURE; CHEMISTRY; CULTURE MEDIUM; CYTOLOGY; FEMALE; GLIA; MALE; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANDROSTENEDIONE; ANDROSTENES; ANIMALS; ASTROCYTES; BRAIN; CATALYSIS; CELLS, CULTURED; CULTURE MEDIA; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; ESTROGENS; FEMALE; HYDROXYCHOLESTEROLS; MALE; NERVOUS SYSTEM; NEUROGLIA; NEUROTRANSMITTER AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SCHWANN CELLS; SCIATIC NERVE; STEROID HYDROXYLASES; STEROIDS;

EID: 84908214055     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.09.022     Document Type: Article

References (40)

1. R.C. Melcangi, and G.C. Panzica Neuroactive steroids: old players in a new game Neuroscience 138 2006 733 739
2. I. Björkhem, A. Cedazo-Minguez, V. Leoni, and S. Meaney Oxysterols and neurodegenerative diseases Mol. Asp. Med. 30 2009 171 179
3. H. Mukai, T. Tsurugizawa, M. Ogiue-Ikeda, G. Murakami, Y. Hojo, H. Ishii, T. Kimoto, and S. Kawato Local neurosteroid production in the hippocampus: influence on synaptic plasticity of memory Neuroendocrinology 84 2006 255 263
4. P. Zheng Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance Prog. Neurobiol. 89 2009 134 152
5. K.A. Rose, G. Stapleton, K. Dott, M.P. Kieny, R. Best, M. Schwarz, D.W. Russell, I. Björkhem, J. Seckl, and R. Lathe Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7α-hydroxy dehydroepiandrosterone and 7α-hydroxy pregnenolone Proc. Natl. Acad. Sci. U. S. A. 94 1997 4925 4930
6. N. Maninger, O.M. Wolkowitz, V.I. Reus, E.S. Epel, and S.H. Mellon Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) Front. Neuroendocrinol. 30 2009 65 91
7. P. Micevych, and K. Sinchak Estradiol regulation of progesterone synthesis in the brain Mol. Cell. Endocrinol. 290 2008 44 50
8. M. Starka Dehydroepiandrosterone: a neuroactive steroid J. Steroid Biochem. Mol. Biol. 2014
9. A. Radhakrishnan, Y. Ikeda, H.J. Kwon, M.S. Brown, and J.L. Goldstein Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig Proc. Natl. Acad. Sci. U. S. A. 104 2007 6511 6518
10. A. Vejux, and G. Lizard Cytotoxic effects of oxysterols associated with human diseases: induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis Mol. Asp. Med. 30 2009 153 170
11. I. Emanuelsson, and M. Norlin Effects of oxysterols on staurosporine-induced cell death in neuroblastoma SH-SY5Y cells Neurosci. Lett. 525 2012 44 48
12. P.H. Jellinck, M. Kaufmann, A. Gottfried-Blackmore, B.S. McEwen, G. Jones, and K. Bulloch Selective conversion by microglia of dehydroepiandrosterone to 5-androstenediol - a steroid with inherent estrogenic properties J. Steroid Biochem. Mol. Biol. 107 2007 156 162
13. J. Lundqvist, M. Norlin, and K. Wikvall 1α,25-Dihydroxyvitamin D3 affects hormone production and expression of steroidogenic enzymes in human adrenocortical NCI-H295R cells Biochim. Biophys. Acta 1801 2010 1056 1062
14. J. Lundqvist, and M. Norlin Effects of CYP7B1-related steroids on androgen receptor activation in different cell lines Biochim. Biophys. Acta 1821 2012 973 979
15. I.H. Zwain, and S.S. Yen Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain Endocrinology 140 1999 3843 3852
16. K.R. Jessen Glial cells Int. J. Biochem. Cell Biol. 36 2004 1861 1867
17. R.C. Melcangi, I.T. Cavarretta, M. Ballabio, E. Leonelli, A. Schenone, I. Azcoitia, L. Miguel Garcia-Segura, and V. Magnaghi Peripheral nerves: a target for the action of neuroactive steroids Brain Res. Rev. 48 2005 328 338
18. Å. Fex Svenningsen, G. Wicher, J. Lundqvist, H. Pettersson, M. Corell, and M. Norlin Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism Neurochem. Int. 58 2011 620 624
19. R. Morfin, and L. Starka Neurosteroid 7-hydroxylation products in the brain Int. Rev. Neurobiol. 46 2001 79 95
20. M. Olsson, O. Gustafsson, C. Skogastierna, A. Tolf, B.D. Rietz, R. Morfin, A. Rane, and L. Ekström Regulation and expression of human CYP7B1 in prostate: overexpression of CYP7B1 during progression of prostatic adenocarcinoma Prostate 67 2007 1439 1446
21. H. Pettersson, J. Lundqvist, E. Oliw, and M. Norlin CYP7B1-mediated metabolism of 5α-androstane-3α,17β-diol (3α-a novel): pathway for potential regulation of the cellular levels of androgens and neurosteroidsBiochim Biophys. Acta 1791 2009 1206 1215
22. M.K. Tsaousidou, K. Ouahchi, T.T. Warner, Y. Yang, M.A. Simpson, N.G. Laing, P.A. Wilkinson, R.E. Madrid, H. Patel, F. Hentati, M.A. Patton, A. Hentati, P.J. Lamont, T. Siddique, and A.H. Crosby Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration Am. J. Hum. Genet. 82 2008 510 515
23. K.D. McCarthy, and J. de Vellis Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue J. Cell Biol. 85 1980 890 902
24. K. Haastert, C. Mauritz, S. Chaturvedi, and C. Grothe Human and rat adult Schwann cell cultures: fast and efficient enrichment and highly effective non-viral transfection protocol Nat. Protoc. 2 2007 99 104
25. L. Morgan, K.R. Jessen, and R. Mirsky The effects of cAMP on differentiation of cultured Schwann cells: progression from an early phenotype (04+) to a myelin phenotype (P0+, GFAP-, N-CAM-, NGF-receptor-) depends on growth inhibition J. Cell Biol. 112 1991 457 467
26. J.P. Brockes, K.L. Fields, and M.C. Raff Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve Brain Res. 165 1979 105 118
27. K. Jirsova, P. Sodaar, V. Mandys, and P.R. Bar Cold jet: a method to obtain pure Schwann cell cultures without the need for cytotoxic apoptosis-inducing drug treatment J. Neurosci. Methods 78 1997 133 137
28. M. Norlin, and K. Wikvall Biochemical characterization of the 7α-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes Biochim. Biophys. Acta 1390 1998 269 281
29. H. Pettersson, L. Holmberg, M. Axelson, and M. Norlin CYP7B1-mediated metabolism of dehydroepiandrosterone and 5α-androstane-3β,17β-diol - potential role(s) for estrogen signaling FEBS J. 275 2008 1778 1789
30. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
31. T.S. Zhu, and M. Glaser Regulatory role of cytochrome P450scc and pregnenolone in myelination by rat Schwann cells Mol. Cell. Biochem. 313 2008 79 89
32. I. Charalampopoulos, V.I. Alexaki, C. Tsatsanis, V. Minas, E. Dermitzaki, I. Lasaridis, L. Vardouli, C. Stournaras, A.N. Margioris, E. Castanas, and A. Gravanis Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging Ann. N. Y. Acad. Sci. 1088 2006 139 152
33. C.E. Marx, D.W. Bradford, R.M. Hamer, J.C. Naylor, T.B. Allen, J.A. Lieberman, J.L. Strauss, and J.D. Kilts Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence Neuroscience 191 2011 78 90
34. Y. Akwa, N. Sananes, M. Gouezou, P. Robel, E.E. Baulieu, and C. Le Goascogne Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density J. Cell Biol. 121 1993 135 143
35. J. Zhang, Y. Akwa, M. el-Etr, E.E. Baulieu, and J. Sjövall Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons Biochem. J. 322 Pt 1 1997 175 184
36. K.M. Dhandapani, and D.W. Brann Role of astrocytes in estrogen-mediated neuroprotection Exp. Gerontol. 42 2007 70 75
37. P. Micevych, G. Bondar, and J. Kuo Estrogen actions on neuroendocrine glia Neuroendocrinology 91 2010 211 222
38. 2-induced cytotoxicity and increases transplanted Schwann cell survival in a cervical hemicontusion spinal cord injury model J. Neurochem. 115 2010 864 872
39. D. Garcia-Ovejero, I. Azcoitia, L.L. Doncarlos, R.C. Melcangi, and L.M. Garcia-Segura Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones Brain Res. Rev. 48 2005 273 286
40. R. Hampl, M. Hill, and L. Starka 7-Hydroxydehydroepiandrosterone epimers in the life span J. Steroid Biochem. Mol. Biol. 78 2001 367 372