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Volumn 1390, Issue 3, 1998, Pages 269-281

Biochemical characterization of the 7α-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes

Author keywords

27 Hydroxycholesterol; 7 Hydroxylation; Cytochrome P 450; Dehydroepiandrosterone; Liver microsome; Steroid metabolism

Indexed keywords

CYTOCHROME P450; OXYGENASE; 25 HYDROXYCHOLESTEROL; 25-HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; 27-HYDROXYCHOLESTEROL; CHOLESTEROL DERIVATIVE; ENZYME INHIBITOR; PRASTERONE; PREGNENOLONE;

EID: 0032559475     PISSN: 00052760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2760(97)00193-8     Document Type: Article
Times cited : (17)

References (44)
  • 1
    • 0025045782 scopus 로고
    • Potential bile acid precursors in plasma - possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man
    • Axelsson M., Sjövall J. Potential bile acid precursors in plasma - possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man. J. Steroid Biochem. 36:1990;631-640.
    • (1990) J. Steroid Biochem. , vol.36 , pp. 631-640
    • Axelsson, M.1    Sjövall, J.2
  • 2
    • 0026551710 scopus 로고
    • Mechanism of degradation of the steroid side chain in the formation of bile acids
    • Björkhem I. Mechanism of degradation of the steroid side chain in the formation of bile acids. J. Lipid Res. 33:1992;455-468.
    • (1992) J. Lipid Res. , vol.33 , pp. 455-468
    • Björkhem, I.1
  • 3
    • 0022993462 scopus 로고
    • Bile acid synthesis. Metabolism of 3β-hydroxy-5-cholenoic acid to chenodeoxycholic acid
    • Javitt N.B., Kok E., Carubbi F., Blizzard T., Gut M., Byon C.Y. Bile acid synthesis. Metabolism of 3β-hydroxy-5-cholenoic acid to chenodeoxycholic acid. J. Biol. Chem. 261:1986;12486-12489.
    • (1986) J. Biol. Chem. , vol.261 , pp. 12486-12489
    • Javitt, N.B.1    Kok, E.2    Carubbi, F.3    Blizzard, T.4    Gut, M.5    Byon, C.Y.6
  • 4
    • 0023645004 scopus 로고
    • Purification and characterization of cholesterol 7α-hydroxylase from rat liver microsomes
    • Ogishima T., Deguchi S., Okuda K. Purification and characterization of cholesterol 7α-hydroxylase from rat liver microsomes. J. Biol. Chem. 262:1987;7646-7650.
    • (1987) J. Biol. Chem. , vol.262 , pp. 7646-7650
    • Ogishima, T.1    Deguchi, S.2    Okuda, K.3
  • 5
    • 0025269939 scopus 로고
    • Cloning and regulation of cholesterol 7α-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis
    • Jelinek D., Andersson S., Slaughter C.A., Russell D.W. Cloning and regulation of cholesterol 7α-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J. Biol. Chem. 265:1990;8190-8197.
    • (1990) J. Biol. Chem. , vol.265 , pp. 8190-8197
    • Jelinek, D.1    Andersson, S.2    Slaughter, C.A.3    Russell, D.W.4
  • 6
    • 0026500434 scopus 로고
    • 7α-hydroxylation of 26-hydroxycholesterol, 3β-hydroxy-5-cholestenoic acid and 3β-hydroxy-5-cholenoic acid by cytochrome-P-450 in pig liver microsomes
    • Toll A., Shoda J., Axelsson M., Sjövall J., Wikvall K. 7α-hydroxylation of 26-hydroxycholesterol, 3β-hydroxy-5-cholestenoic acid and 3β-hydroxy-5-cholenoic acid by cytochrome-P-450 in pig liver microsomes. FEBS Lett. 296:1992;73-76.
    • (1992) FEBS Lett. , vol.296 , pp. 73-76
    • Toll, A.1    Shoda, J.2    Axelsson, M.3    Sjövall, J.4    Wikvall, K.5
  • 8
    • 0027523427 scopus 로고
    • Cholesterol and 27-hydroxycholesterol 7α-hydroxylation: Evidence for two different enzymes
    • Martin K.O., Budai K., Javitt N.B. Cholesterol and 27-hydroxycholesterol 7α-hydroxylation: evidence for two different enzymes. J. Lipid Res. 34:1993;581-588.
    • (1993) J. Lipid Res. , vol.34 , pp. 581-588
    • Martin, K.O.1    Budai, K.2    Javitt, N.B.3
  • 9
    • 0026738208 scopus 로고
    • 7α-Hydroxylation of 27-hydroxycholesterol in human liver microsomes
    • Björkhem I., Nyberg B., Einarsson K. 7α-Hydroxylation of 27-hydroxycholesterol in human liver microsomes. Biochim. Biophys. Acta. 1128:1992;73-76.
    • (1992) Biochim. Biophys. Acta , vol.1128 , pp. 73-76
    • Björkhem, I.1    Nyberg, B.2    Einarsson, K.3
  • 10
    • 0028168279 scopus 로고
    • 7α-hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from the cholesterol 7α-hydroxylase
    • Toll A., Wikvall K., Sudjana-Sugiaman E., Kondo K.-H., Björkhem I. 7α-hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from the cholesterol 7α-hydroxylase. Eur. J. Biochem. 224:1994;309-316.
    • (1994) Eur. J. Biochem. , vol.224 , pp. 309-316
    • Toll, A.1    Wikvall, K.2    Sudjana-Sugiaman, E.3    Kondo, K.-H.4    Björkhem, I.5
  • 11
    • 0029143894 scopus 로고
    • 7α-hydroxylation of 27-hydroxycholesterol in rat brain microsomes
    • Zhang J., Akwa Y., Baulieu E.-E., Sjövall J. 7α-hydroxylation of 27-hydroxycholesterol in rat brain microsomes. C. R. Acad. Sci. Paris. 318:1995;345-359.
    • (1995) C. R. Acad. Sci. Paris , vol.318 , pp. 345-359
    • Zhang, J.1    Akwa, Y.2    Baulieu, E.-E.3    Sjövall, J.4
  • 12
    • 0031045545 scopus 로고    scopus 로고
    • Metabolism of 27-, 25-, and 24-hydroxycholesterol in rat glial cells and neurons
    • Zhang J., Akwa Y., El-Etr M., Baulieu E.-E., Sjövall J. Metabolism of 27-, 25-, and 24-hydroxycholesterol in rat glial cells and neurons. Biochem. J. 322:1997;175-184.
    • (1997) Biochem. J. , vol.322 , pp. 175-184
    • Zhang, J.1    Akwa, Y.2    El-Etr, M.3    Baulieu, E.-E.4    Sjövall, J.5
  • 13
    • 0029099968 scopus 로고
    • A novel nonhepatic hydroxycholesterol 7α-hydroxylase that is markedly stimulated by interleukin-1β. Characterization in the immature rat ovary
    • Payne D.W., Shackleton C., Toms H., Ben-Shlomo I., Kol S., deMoura M., Strauss J.F., Adashi E.Y. A novel nonhepatic hydroxycholesterol 7α-hydroxylase that is markedly stimulated by interleukin-1β. Characterization in the immature rat ovary. J. Biol. Chem. 270:1995;18888-18896.
    • (1995) J. Biol. Chem. , vol.270 , pp. 18888-18896
    • Payne, D.W.1    Shackleton, C.2    Toms, H.3    Ben-Shlomo, I.4    Kol, S.5    Demoura, M.6    Strauss, J.F.7    Adashi, E.Y.8
  • 14
    • 0028989206 scopus 로고
    • 7α-hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts
    • Zhang J., Larsson O., Sjövall J. 7α-hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts. Biochim. Biophys. Acta. 1256:1995;353-359.
    • (1995) Biochim. Biophys. Acta , vol.1256 , pp. 353-359
    • Zhang, J.1    Larsson, O.2    Sjövall, J.3
  • 15
    • 0014303429 scopus 로고
    • Characterization of microsomal dehydroepiandrosterone 7-hydroxylase from rat liver
    • Sulcová J., Stárka L. Characterization of microsomal dehydroepiandrosterone 7-hydroxylase from rat liver. Steroids. 12:1968;113-126.
    • (1968) Steroids , vol.12 , pp. 113-126
    • Sulcová, J.1    Stárka, L.2
  • 16
    • 0014330770 scopus 로고
    • 7-hydroxylation of dehydroepiandrosterone in human fetal liver, adrenals and chorion in vitro
    • Sulcová J., Capcová A., Jirásek J.E., Stárka L. 7-hydroxylation of dehydroepiandrosterone in human fetal liver, adrenals and chorion in vitro. Acta Endocrinol. (Copenh). 59:1968;1-9.
    • (1968) Acta Endocrinol. (Copenh) , vol.59 , pp. 1-9
    • Sulcová, J.1    Capcová, A.2    Jirásek, J.E.3    Stárka, L.4
  • 17
    • 0015226343 scopus 로고
    • Oxidation of cholesterol, 3β-hydroxy-5-pregnen-20-one and 3β-hydroxy-5-androsten-17-one by rat liver microsomes
    • Johansson G. Oxidation of cholesterol, 3β-hydroxy-5-pregnen-20-one and 3β-hydroxy-5-androsten-17-one by rat liver microsomes. Eur. J. Biochem. 21:1971;68-79.
    • (1971) Eur. J. Biochem. , vol.21 , pp. 68-79
    • Johansson, G.1
  • 18
    • 0016685461 scopus 로고
    • Influence of adrenalectomy, castration, and light cycle on steroid hydroxylase activity in the adult male rat liver
    • Schafer S.J., Colas A.E. Influence of adrenalectomy, castration, and light cycle on steroid hydroxylase activity in the adult male rat liver. Endocrinology. 97:1975;1294-1299.
    • (1975) Endocrinology , vol.97 , pp. 1294-1299
    • Schafer, S.J.1    Colas, A.E.2
  • 19
    • 0030273492 scopus 로고    scopus 로고
    • Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7α-hydroxylation in mouse tissues
    • Doostzadeh J., Morfin R. Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7α-hydroxylation in mouse tissues. Steroids. 61:1996;613-620.
    • (1996) Steroids , vol.61 , pp. 613-620
    • Doostzadeh, J.1    Morfin, R.2
  • 20
    • 0024584510 scopus 로고
    • Purification of two isozymes of rat liver microsomal cytochrome P-450 with testosterone 7α-hydroxylase activity
    • Arlotto M.P., Greenway D.J., Parkinson A. Purification of two isozymes of rat liver microsomal cytochrome P-450 with testosterone 7α-hydroxylase activity. Arch. Biochem. Biophys. 270:1989;441-457.
    • (1989) Arch. Biochem. Biophys. , vol.270 , pp. 441-457
    • Arlotto, M.P.1    Greenway, D.J.2    Parkinson, A.3
  • 21
    • 0024523289 scopus 로고
    • Identification of cytochrome P-450a (P450IIA1) as the principal testosterone 7α-hydroxylase in rat liver microsomes and its regulation by thyroid hormones
    • Arlotto M.P., Parkinson A. Identification of cytochrome P-450a (P450IIA1) as the principal testosterone 7α-hydroxylase in rat liver microsomes and its regulation by thyroid hormones. Arch. Biochem. Biophys. 270:1989;458-471.
    • (1989) Arch. Biochem. Biophys. , vol.270 , pp. 458-471
    • Arlotto, M.P.1    Parkinson, A.2
  • 22
    • 0015221776 scopus 로고
    • Steroid 7α-hydroxylase of rat testes
    • Inano H., Tamaoki B.I. Steroid 7α-hydroxylase of rat testes. Biochemistry. 10:1971;1503-1509.
    • (1971) Biochemistry , vol.10 , pp. 1503-1509
    • Inano, H.1    Tamaoki, B.I.2
  • 23
    • 0027055261 scopus 로고
    • Neurosteroid metabolism. 7α-hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes
    • Akwa Y., Morfin R., Robel P., Baulieu E.-E. Neurosteroid metabolism. 7α-hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes. Biochem. J. 288:1992;959-964.
    • (1992) Biochem. J. , vol.288 , pp. 959-964
    • Akwa, Y.1    Morfin, R.2    Robel, P.3    Baulieu, E.-E.4
  • 24
    • 0027408686 scopus 로고
    • Astrocytes and neurosteroids: Metabolism of pregnenolone and dehydroepiandrosterone regulation by cell density
    • Akwa Y., Sananés N., Gouézou M., Robel P., Baulieu E.-E., Le Goascogne C. Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone regulation by cell density. J. Cell. Biol. 121:1993;135-143.
    • (1993) J. Cell. Biol. , vol.121 , pp. 135-143
    • Akwa, Y.1    Sananés, N.2    Gouézou, M.3    Robel, P.4    Baulieu, E.-E.5    Le Goascogne, C.6
  • 25
    • 0028206488 scopus 로고
    • Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice
    • Morfin R., Courchay G. Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice. J. Steroid Biochem. Mol. Biol. 50:1994;91-100.
    • (1994) J. Steroid Biochem. Mol. Biol. , vol.50 , pp. 91-100
    • Morfin, R.1    Courchay, G.2
  • 32
    • 0021891305 scopus 로고
    • Purification from rabbit and rat liver of cytochromes P-450 involved in bile acid biosynthesis
    • Andersson S., Boström H., Danielsson H., Wikvall K. Purification from rabbit and rat liver of cytochromes P-450 involved in bile acid biosynthesis. Methods Enzymol. 111:1985;364-377.
    • (1985) Methods Enzymol. , vol.111 , pp. 364-377
    • Andersson, S.1    Boström, H.2    Danielsson, H.3    Wikvall, K.4
  • 35
    • 0017088267 scopus 로고
    • Some properties of a detergent-solubilized NADPH cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography
    • Yasukochi Y., Masters B.S.S. Some properties of a detergent-solubilized NADPH cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography. J. Biol. Chem. 251:1976;5337-5344.
    • (1976) J. Biol. Chem. , vol.251 , pp. 5337-5344
    • Yasukochi, Y.1    Masters, B.S.S.2
  • 36
    • 0026007201 scopus 로고
    • Bile acid synthesis in cultured human hepatoblastoma cells
    • Axelsson M., Mörk B., Everson G.T. Bile acid synthesis in cultured human hepatoblastoma cells. J. Biol. Chem. 266:1991;17770-17777.
    • (1991) J. Biol. Chem. , vol.266 , pp. 17770-17777
    • Axelsson, M.1    Mörk, B.2    Everson, G.T.3
  • 37
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 38
    • 0019882018 scopus 로고
    • Silver staining of proteins in polyacrylamide gels
    • Wray W., Boulikas T., Wray V.P., Hancock R. Silver staining of proteins in polyacrylamide gels. Anal. Biochem. 118:1981;197-203.
    • (1981) Anal. Biochem. , vol.118 , pp. 197-203
    • Wray, W.1    Boulikas, T.2    Wray, V.P.3    Hancock, R.4
  • 39
    • 0021183454 scopus 로고
    • Effect of disulfiram on rat liver cholesterol 7α-hydroxylase
    • Andersson S., Boström H. Effect of disulfiram on rat liver cholesterol 7α-hydroxylase. Biochem. Pharmac. 33:1984;2930-2932.
    • (1984) Biochem. Pharmac. , vol.33 , pp. 2930-2932
    • Andersson, S.1    Boström, H.2
  • 40
    • 0020531983 scopus 로고
    • Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P-450-dependent enzymes
    • Loose D.S., Kan P.B., Hirst M.A., Marcus R.A., Feldman D. Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P-450-dependent enzymes. J. Clin. Invest. 71:1983;1495-1499.
    • (1983) J. Clin. Invest. , vol.71 , pp. 1495-1499
    • Loose, D.S.1    Kan, P.B.2    Hirst, M.A.3    Marcus, R.A.4    Feldman, D.5
  • 42
    • 0028260591 scopus 로고
    • Effect of dexamethasone and cytochrome P-450 inhibitors on the formation of 7α-hydroxydehydroepiandrosterone by human adipose stromal cells
    • Khalil M.W., Strutt B., Vachon D., Killinger D.W. Effect of dexamethasone and cytochrome P-450 inhibitors on the formation of 7α-hydroxydehydroepiandrosterone by human adipose stromal cells. J. Steroid Biochem. Mol. Biol. 48:1994;545-552.
    • (1994) J. Steroid Biochem. Mol. Biol. , vol.48 , pp. 545-552
    • Khalil, M.W.1    Strutt, B.2    Vachon, D.3    Killinger, D.W.4
  • 43
    • 0025323155 scopus 로고
    • Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents
    • Murray M., Reidy G.F. Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents. Pharmacol. Rev. 42:1990;85-101.
    • (1990) Pharmacol. Rev. , vol.42 , pp. 85-101
    • Murray, M.1    Reidy, G.F.2


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