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Volumn 18, Issue 9, 2014, Pages 1874-1888

Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation

Author keywords

Alzheimer's disease; Gliogenesis; Human embryonic stem cells; Human microglia; Inflammation; Neurogenesis; Neurospheres

Indexed keywords

ACETYLCHOLINE; AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); CHOLINE ACETYLTRANSFERASE; CHOLINESTERASE; CYTOKINE; PEPTIDE FRAGMENT;

EID: 84908212696     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12343     Document Type: Article
Times cited : (29)

References (55)
  • 1
    • 17844404517 scopus 로고    scopus 로고
    • Microglia and neuroprotection: implications for Alzheimer's disease
    • Streit WJ. Microglia and neuroprotection: implications for Alzheimer's disease. Brain Res Brain Res Rev. 2005; 48: 234-9.
    • (2005) Brain Res Brain Res Rev , vol.48 , pp. 234-239
    • Streit, W.J.1
  • 2
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • Akiyama H, Barger S, Barnum S, et al. Inflammation and Alzheimer's disease. Neurobiol Aging. 2000; 21: 383-421.
    • (2000) Neurobiol Aging , vol.21 , pp. 383-421
    • Akiyama, H.1    Barger, S.2    Barnum, S.3
  • 3
    • 11544279355 scopus 로고    scopus 로고
    • Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
    • Lambert MP, Barlow AK, Chromy BA, et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA. 1998; 95: 6448-53.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6448-6453
    • Lambert, M.P.1    Barlow, A.K.2    Chromy, B.A.3
  • 4
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • Shankar GM, Bloodgood BL, Townsend M, et al. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007; 27: 2866-75.
    • (2007) J Neurosci , vol.27 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3
  • 5
    • 79952810857 scopus 로고    scopus 로고
    • Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity
    • Maezawa I, Zimin PI, Wulff H, et al. Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem. 2011; 286: 3693-706.
    • (2011) J Biol Chem , vol.286 , pp. 3693-3706
    • Maezawa, I.1    Zimin, P.I.2    Wulff, H.3
  • 6
    • 33745782720 scopus 로고    scopus 로고
    • Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration
    • Garcao P, Oliveira CR, Agostinho P. Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration. J Neurosci Res. 2006; 84: 182-93.
    • (2006) J Neurosci Res , vol.84 , pp. 182-193
    • Garcao, P.1    Oliveira, C.R.2    Agostinho, P.3
  • 7
    • 77955936819 scopus 로고    scopus 로고
    • Effects of immunomodulatory substances on phagocytosis of abeta(1-42) by human microglia
    • doi:10.4061/2010/798424.
    • Hjorth E, Frenkel D, Weiner H, et al. Effects of immunomodulatory substances on phagocytosis of abeta(1-42) by human microglia. Int J Alzheimers Dis. 2010; 2010: doi:10.4061/2010/798424.
    • (2010) Int J Alzheimers Dis , vol.2010
    • Hjorth, E.1    Frenkel, D.2    Weiner, H.3
  • 8
    • 73649137143 scopus 로고    scopus 로고
    • Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease
    • Doi Y, Mizuno T, Maki Y, et al. Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease. Am J Pathol. 2009; 175: 2121-32.
    • (2009) Am J Pathol , vol.175 , pp. 2121-2132
    • Doi, Y.1    Mizuno, T.2    Maki, Y.3
  • 9
    • 33750550678 scopus 로고    scopus 로고
    • Microglia instruct subventricular zone neurogenesis
    • Walton NM, Sutter BM, Laywell ED, et al. Microglia instruct subventricular zone neurogenesis. Glia. 2006; 54: 815-25.
    • (2006) Glia , vol.54 , pp. 815-825
    • Walton, N.M.1    Sutter, B.M.2    Laywell, E.D.3
  • 10
    • 0345189366 scopus 로고    scopus 로고
    • Inflammatory blockade restores adult hippocampal neurogenesis
    • Monje ML, Toda H, Palmer TD. Inflammatory blockade restores adult hippocampal neurogenesis. Science. 2003; 302: 1760-5.
    • (2003) Science , vol.302 , pp. 1760-1765
    • Monje, M.L.1    Toda, H.2    Palmer, T.D.3
  • 11
    • 0344742225 scopus 로고    scopus 로고
    • Inflammation is detrimental for neurogenesis in adult brain
    • Ekdahl CT, Claasen JH, Bonde S, et al. Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci USA. 2003; 100: 13632-7.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 13632-13637
    • Ekdahl, C.T.1    Claasen, J.H.2    Bonde, S.3
  • 12
    • 13244249820 scopus 로고    scopus 로고
    • Autonomic neural regulation of immunity
    • Czura CJ, Tracey KJ. Autonomic neural regulation of immunity. J Intern Med. 2005; 257: 156-66.
    • (2005) J Intern Med , vol.257 , pp. 156-166
    • Czura, C.J.1    Tracey, K.J.2
  • 13
    • 80053646543 scopus 로고    scopus 로고
    • Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo
    • 2320e15-2320e32
    • Darreh-Shori T, Forsberg A, Modiri N, et al. Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo. Neurobiol Aging. 2011; 32: 2320.e15-32.
    • (2011) Neurobiol Aging , vol.32
    • Darreh-Shori, T.1    Forsberg, A.2    Modiri, N.3
  • 14
    • 79952231145 scopus 로고    scopus 로고
    • The apolipoprotein E epsilon4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase
    • Darreh-Shori T, Modiri N, Blennow K, et al. The apolipoprotein E epsilon4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase. Neurobiol Aging. 2011; 32: 1236-48.
    • (2011) Neurobiol Aging , vol.32 , pp. 1236-1248
    • Darreh-Shori, T.1    Modiri, N.2    Blennow, K.3
  • 15
    • 84856996462 scopus 로고    scopus 로고
    • Apolipoprotein E and Butyrylcholinesterase synergistically promote Ab peptides oligomerization
    • Available at
    • Darreh-Shori T, Modiri N, Lahaut P, et al. Apolipoprotein E and Butyrylcholinesterase synergistically promote Ab peptides oligomerization. Alzheimer's & Dementia. 2009; 5: P225. Available at http://linkinghubelseviercom/retrieve/pii/S1552526009001915.
    • (2009) Alzheimer's & Dementia , vol.5 , pp. P225
    • Darreh-Shori, T.1    Modiri, N.2    Lahaut, P.3
  • 16
    • 80053620926 scopus 로고    scopus 로고
    • ApoE and amyloid beta deflate the cholinergic neurotransmission by boosting the activity and stability of cholinesterases in the brain
    • Available at
    • Darreh-Shori T, Modiri N, Nordberg A. ApoE and amyloid beta deflate the cholinergic neurotransmission by boosting the activity and stability of cholinesterases in the brain. Alzheimer's & Dementia. 2009; 5: P305. Available at http://linkinghubelseviercom/retrieve/pii/S1552526009005858
    • (2009) Alzheimer's & Dementia , vol.5 , pp. P305
    • Darreh-Shori, T.1    Modiri, N.2    Nordberg, A.3
  • 17
    • 84879209063 scopus 로고    scopus 로고
    • Regulated extracellular choline acetyltransferase activity- the plausible missing link of the distant action of acetylcholine in the cholinergic anti-inflammatory pathway
    • Vijayaraghavan S, Karami A, Aeinehband S, et al. Regulated extracellular choline acetyltransferase activity- the plausible missing link of the distant action of acetylcholine in the cholinergic anti-inflammatory pathway. PLoS ONE. 2013; 8: e65936.
    • (2013) PLoS ONE , vol.8 , pp. e65936
    • Vijayaraghavan, S.1    Karami, A.2    Aeinehband, S.3
  • 18
    • 78650786023 scopus 로고    scopus 로고
    • Beta-amyloid 1-42 oligomers impair function of human embryonic stem cell-derived forebrain cholinergic neurons
    • Wicklund L, Leao RN, Stromberg AM, et al. Beta-amyloid 1-42 oligomers impair function of human embryonic stem cell-derived forebrain cholinergic neurons. PLoS ONE. 2010; 5: e15600.
    • (2010) PLoS ONE , vol.5 , pp. e15600
    • Wicklund, L.1    Leao, R.N.2    Stromberg, A.M.3
  • 19
    • 11144357877 scopus 로고    scopus 로고
    • Differences between human and mouse embryonic stem cells
    • Ginis I, Luo Y, Miura T, et al. Differences between human and mouse embryonic stem cells. Dev Biol. 2004; 269: 360-80.
    • (2004) Dev Biol , vol.269 , pp. 360-380
    • Ginis, I.1    Luo, Y.2    Miura, T.3
  • 20
    • 33751217707 scopus 로고    scopus 로고
    • Culture conditions for human embryonic stem cells
    • Skottman H, Hovatta O. Culture conditions for human embryonic stem cells. Reproduction. 2006; 132: 691-8.
    • (2006) Reproduction , vol.132 , pp. 691-698
    • Skottman, H.1    Hovatta, O.2
  • 21
    • 33846971644 scopus 로고    scopus 로고
    • Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum-free suspension and adherent cultures
    • Nat R, Nilbratt M, Narkilahti S, et al. Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum-free suspension and adherent cultures. Glia. 2007; 55: 385-99.
    • (2007) Glia , vol.55 , pp. 385-399
    • Nat, R.1    Nilbratt, M.2    Narkilahti, S.3
  • 22
    • 84860849630 scopus 로고    scopus 로고
    • The immune plasticity of mesenchymal stromal cells from mice and men: concordances and discrepancies
    • Romieu-Mourez R, Coutu DL, Galipeau J. The immune plasticity of mesenchymal stromal cells from mice and men: concordances and discrepancies. Front Biosci (Elite Ed). 2012; 4: 824-37.
    • (2012) Front Biosci (Elite Ed) , vol.4 , pp. 824-837
    • Romieu-Mourez, R.1    Coutu, D.L.2    Galipeau, J.3
  • 23
    • 77956410881 scopus 로고    scopus 로고
    • Innate immunity in human embryonic stem cells: comparison with adult human endothelial cells
    • Foldes G, Liu A, Badiger R, et al. Innate immunity in human embryonic stem cells: comparison with adult human endothelial cells. PLoS ONE. 2010; 5: e10501.
    • (2010) PLoS ONE , vol.5 , pp. e10501
    • Foldes, G.1    Liu, A.2    Badiger, R.3
  • 24
    • 55049090532 scopus 로고    scopus 로고
    • Effect of inflammatory cytokines on major histocompatibility complex expression and differentiation of human neural stem/progenitor cells
    • Johansson S, Price J, Modo M. Effect of inflammatory cytokines on major histocompatibility complex expression and differentiation of human neural stem/progenitor cells. Stem Cells. 2008; 26: 2444-54.
    • (2008) Stem Cells , vol.26 , pp. 2444-2454
    • Johansson, S.1    Price, J.2    Modo, M.3
  • 25
    • 84864449051 scopus 로고    scopus 로고
    • Cross-talk between neural stem cells and immune cells: the key to better brain repair?
    • Kokaia Z, Martino G, Schwartz M, et al. Cross-talk between neural stem cells and immune cells: the key to better brain repair? Nat Neurosci. 2012; 15: 1078-87.
    • (2012) Nat Neurosci , vol.15 , pp. 1078-1087
    • Kokaia, Z.1    Martino, G.2    Schwartz, M.3
  • 26
    • 84873902758 scopus 로고    scopus 로고
    • Human neural stem/progenitor cells derived from embryonic stem cells and fetal nervous system present differences in immunogenicity and immunomodulatory potentials in vitro
    • Liu J, Gotherstrom C, Forsberg M, et al. Human neural stem/progenitor cells derived from embryonic stem cells and fetal nervous system present differences in immunogenicity and immunomodulatory potentials in vitro. Stem Cell Research. 2013; 10: 325-37.
    • (2013) Stem Cell Research , vol.10 , pp. 325-337
    • Liu, J.1    Gotherstrom, C.2    Forsberg, M.3
  • 27
    • 16444368386 scopus 로고    scopus 로고
    • Derivation of human embryonic stem cell lines in serum replacement medium using postnatal human fibroblasts as feeder cells
    • Inzunza J, Gertow K, Stromberg MA, et al. Derivation of human embryonic stem cell lines in serum replacement medium using postnatal human fibroblasts as feeder cells. Stem Cells. 2005; 23: 544-9.
    • (2005) Stem Cells , vol.23 , pp. 544-549
    • Inzunza, J.1    Gertow, K.2    Stromberg, M.A.3
  • 28
    • 40449092159 scopus 로고    scopus 로고
    • Mechanical isolation of the inner cell mass is effective in derivation of new human embryonic stem cell lines
    • Strom S, Inzunza J, Grinnemo KH, et al. Mechanical isolation of the inner cell mass is effective in derivation of new human embryonic stem cell lines. Hum Reprod. 2007; 22: 3051-8.
    • (2007) Hum Reprod , vol.22 , pp. 3051-3058
    • Strom, S.1    Inzunza, J.2    Grinnemo, K.H.3
  • 29
    • 77952092240 scopus 로고    scopus 로고
    • Derivation of 30 human embryonic stem cell lines-improving the quality
    • Strom S, Holm F, Bergstrom R, et al. Derivation of 30 human embryonic stem cell lines-improving the quality. In Vitro Cell Dev Biol Anim. 2010; 46: 337-44.
    • (2010) In Vitro Cell Dev Biol Anim , vol.46 , pp. 337-344
    • Strom, S.1    Holm, F.2    Bergstrom, R.3
  • 30
    • 77955164446 scopus 로고    scopus 로고
    • Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons
    • Nilbratt M, Porras O, Marutle A, et al. Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons. J Cell Mol Med. 2010; 14: 1476-84.
    • (2010) J Cell Mol Med , vol.14 , pp. 1476-1484
    • Nilbratt, M.1    Porras, O.2    Marutle, A.3
  • 31
    • 77949555201 scopus 로고    scopus 로고
    • Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: an exploratory study
    • Degerman Gunnarsson M, Lindau M, Wall A, et al. Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: an exploratory study. Dement Geriatr Cogn Disord. 2010; 29: 204-12.
    • (2010) Dement Geriatr Cogn Disord , vol.29 , pp. 204-212
    • Degerman Gunnarsson, M.1    Lindau, M.2    Wall, A.3
  • 32
    • 33750005095 scopus 로고    scopus 로고
    • Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism
    • Darreh-Shori T, Brimijoin S, Kadir A, et al. Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism. Neurobiol Dis. 2006; 24: 326-33.
    • (2006) Neurobiol Dis , vol.24 , pp. 326-333
    • Darreh-Shori, T.1    Brimijoin, S.2    Kadir, A.3
  • 33
    • 33750472319 scopus 로고    scopus 로고
    • Changes in the activity and protein levels of CSF acetylcholinesterases in relation to cognitive function of patients with mild Alzheimer's disease following chronic donepezil treatment
    • Darreh-Shori T, Meurling L, Pettersson T, et al. Changes in the activity and protein levels of CSF acetylcholinesterases in relation to cognitive function of patients with mild Alzheimer's disease following chronic donepezil treatment. J Neural Transm. 2006; 113: 1791-801.
    • (2006) J Neural Transm , vol.113 , pp. 1791-1801
    • Darreh-Shori, T.1    Meurling, L.2    Pettersson, T.3
  • 34
    • 84881544585 scopus 로고    scopus 로고
    • Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease
    • Darreh-Shori T, Vijayaraghavan S, Aeinehband S, et al. Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease. Neurobiol Aging. 2013; 34: 2465-81.
    • (2013) Neurobiol Aging , vol.34 , pp. 2465-2481
    • Darreh-Shori, T.1    Vijayaraghavan, S.2    Aeinehband, S.3
  • 35
    • 77956961694 scopus 로고    scopus 로고
    • Neuroinflammatory processes in Alzheimer's disease
    • Heneka MT, O'Banion MK, Terwel D, et al. Neuroinflammatory processes in Alzheimer's disease. J Neural Transm. 2010; 117: 919-47.
    • (2010) J Neural Transm , vol.117 , pp. 919-947
    • Heneka, M.T.1    O'Banion, M.K.2    Terwel, D.3
  • 36
    • 0032495195 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase expression is selectively induced in astrocytes isolated from adult human brain
    • Zhao ML, Liu JS, He D, et al. Inducible nitric oxide synthase expression is selectively induced in astrocytes isolated from adult human brain. Brain Res. 1998; 813: 402-5.
    • (1998) Brain Res , vol.813 , pp. 402-405
    • Zhao, M.L.1    Liu, J.S.2    He, D.3
  • 37
    • 0037180778 scopus 로고    scopus 로고
    • The inflammatory reflex
    • Tracey KJ. The inflammatory reflex. Nature. 2002; 420: 853-9.
    • (2002) Nature , vol.420 , pp. 853-859
    • Tracey, K.J.1
  • 38
    • 84856992257 scopus 로고    scopus 로고
    • Apolipoprotein epsilon4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer's disease
    • Darreh-Shori T, Siawesh M, Mousavi M, et al. Apolipoprotein epsilon4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer's disease. J Alzheimers Dis. 2012; 28: 443-58.
    • (2012) J Alzheimers Dis , vol.28 , pp. 443-458
    • Darreh-Shori, T.1    Siawesh, M.2    Mousavi, M.3
  • 39
    • 0037079993 scopus 로고    scopus 로고
    • Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6
    • Vallieres L, Campbell IL, Gage FH, et al. Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J Neurosci. 2002; 22: 486-92.
    • (2002) J Neurosci , vol.22 , pp. 486-492
    • Vallieres, L.1    Campbell, I.L.2    Gage, F.H.3
  • 40
    • 79551515835 scopus 로고    scopus 로고
    • Adult interleukin-6 knockout mice show compromised neurogenesis
    • Bowen KK, Dempsey RJ, Vemuganti R. Adult interleukin-6 knockout mice show compromised neurogenesis. NeuroReport. 2011; 22: 126-30.
    • (2011) NeuroReport , vol.22 , pp. 126-130
    • Bowen, K.K.1    Dempsey, R.J.2    Vemuganti, R.3
  • 41
    • 41949085038 scopus 로고    scopus 로고
    • Class III beta-tubulin is constitutively coexpressed with glial fibrillary acidic protein and nestin in midgestational human fetal astrocytes: implications for phenotypic identity
    • Draberova E, Del Valle L, Gordon J, et al. Class III beta-tubulin is constitutively coexpressed with glial fibrillary acidic protein and nestin in midgestational human fetal astrocytes: implications for phenotypic identity. J Neuropathol Exp Neurol. 2008; 67: 341-54.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 341-354
    • Draberova, E.1    Del Valle, L.2    Gordon, J.3
  • 42
    • 84855369203 scopus 로고    scopus 로고
    • Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG
    • Carter SF, Scholl M, Almkvist O, et al. Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG. J Nucl Med. 2012; 53: 37-46.
    • (2012) J Nucl Med , vol.53 , pp. 37-46
    • Carter, S.F.1    Scholl, M.2    Almkvist, O.3
  • 43
    • 0025352661 scopus 로고
    • Microtubule-associated proteins and the determination of neuronal form
    • Matus A. Microtubule-associated proteins and the determination of neuronal form. J Physiol. 1990; 84: 134-7.
    • (1990) J Physiol , vol.84 , pp. 134-137
    • Matus, A.1
  • 44
    • 55049114476 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures
    • Bernardino L, Agasse F, Silva B, et al. Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures. Stem Cells. 2008; 26: 2361-71.
    • (2008) Stem Cells , vol.26 , pp. 2361-2371
    • Bernardino, L.1    Agasse, F.2    Silva, B.3
  • 45
    • 38949139570 scopus 로고    scopus 로고
    • In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia
    • Cacci E, Ajmone-Cat MA, Anelli T, et al. In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia. Glia. 2008; 56: 412-25.
    • (2008) Glia , vol.56 , pp. 412-425
    • Cacci, E.1    Ajmone-Cat, M.A.2    Anelli, T.3
  • 46
    • 39049146540 scopus 로고    scopus 로고
    • Blunted neurogenesis and gliosis due to transgenic overexpression of human soluble IL-1ra in the mouse
    • Spulber S, Oprica M, Bartfai T, et al. Blunted neurogenesis and gliosis due to transgenic overexpression of human soluble IL-1ra in the mouse. Eur J Neurosci. 2008; 27: 549-58.
    • (2008) Eur J Neurosci , vol.27 , pp. 549-558
    • Spulber, S.1    Oprica, M.2    Bartfai, T.3
  • 47
    • 66449111088 scopus 로고    scopus 로고
    • Reflex control of immunity
    • Tracey KJ. Reflex control of immunity. Nat Rev Immunol. 2009; 9: 418-28.
    • (2009) Nat Rev Immunol , vol.9 , pp. 418-428
    • Tracey, K.J.1
  • 48
    • 75449116560 scopus 로고    scopus 로고
    • Inhibitory role of cholinergic system mediated via alpha7 nicotinic acetylcholine receptor in LPS-induced neuro-inflammation
    • Tyagi E, Agrawal R, Nath C, et al. Inhibitory role of cholinergic system mediated via alpha7 nicotinic acetylcholine receptor in LPS-induced neuro-inflammation. Innate Immun. 2010; 16: 3-13.
    • (2010) Innate Immun , vol.16 , pp. 3-13
    • Tyagi, E.1    Agrawal, R.2    Nath, C.3
  • 49
    • 11144355227 scopus 로고    scopus 로고
    • Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors
    • Shytle RD, Mori T, Townsend K, et al. Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors. J Neurochem. 2004; 89: 337-43.
    • (2004) J Neurochem , vol.89 , pp. 337-343
    • Shytle, R.D.1    Mori, T.2    Townsend, K.3
  • 50
    • 77955510036 scopus 로고    scopus 로고
    • Acetylcholine as a possible signaling molecule in embryonic stem cells: studies on survival, proliferation and death
    • Landgraf D, Barth M, Layer PG, et al. Acetylcholine as a possible signaling molecule in embryonic stem cells: studies on survival, proliferation and death. Chem Biol Interact. 2010; 187: 115-9.
    • (2010) Chem Biol Interact , vol.187 , pp. 115-119
    • Landgraf, D.1    Barth, M.2    Layer, P.G.3
  • 51
    • 84856971964 scopus 로고    scopus 로고
    • Different beta-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity
    • 825e1-82513
    • Bao F, Wicklund L, Lacor PN, et al. Different beta-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity. Neurobiol Aging. 2012; 33: 825.e1-13.
    • (2012) Neurobiol Aging , vol.33
    • Bao, F.1    Wicklund, L.2    Lacor, P.N.3
  • 52
    • 78650698306 scopus 로고    scopus 로고
    • Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease
    • Kadir A, Marutle A, Gonzalez D, et al. Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease. Brain. 2011; 134: 301-17.
    • (2011) Brain , vol.134 , pp. 301-317
    • Kadir, A.1    Marutle, A.2    Gonzalez, D.3
  • 53
    • 4644320679 scopus 로고    scopus 로고
    • Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease
    • Geula C, Darvesh S. Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease. Drugs Today (Barc). 2004; 40: 711-21.
    • (2004) Drugs Today (Barc) , vol.40 , pp. 711-721
    • Geula, C.1    Darvesh, S.2
  • 54
    • 84872706357 scopus 로고    scopus 로고
    • Review: activation patterns of microglia and their identification in the human brain
    • Boche D, Perry VH, Nicoll JA. Review: activation patterns of microglia and their identification in the human brain. Neuropathol Appl Neurobiol. 2013; 39: 3-18.
    • (2013) Neuropathol Appl Neurobiol , vol.39 , pp. 3-18
    • Boche, D.1    Perry, V.H.2    Nicoll, J.A.3
  • 55
    • 3042845492 scopus 로고    scopus 로고
    • Microglia and Alzheimer's disease pathogenesis
    • Streit WJ. Microglia and Alzheimer's disease pathogenesis. J Neurosci Res. 2004; 77: 1-8.
    • (2004) J Neurosci Res , vol.77 , pp. 1-8
    • Streit, W.J.1


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