How to reduce the accumulation of autophagic vacuoles in NPC1-deficient neurons: A comparison of two pharmacological strategies

Neuropharmacology

Volumn 89, Issue , 2015, Pages 282-289

  Meske, Volker ^a   Priesnitz, Timm ^a   Albert, Frank ^a   Ohm, Thomas Georg ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Autophagy; C disease; Cyclodextrin; Neurons; Niemann Pick type; PI3K inhibitor

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 3 METHYLADENINE; CHOLESTEROL; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; 3-METHYLADENINE; ADENINE; BETA CYCLODEXTRIN DERIVATIVE; ENZYME INHIBITOR; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; NPC1 PROTEIN, MOUSE; PROTEIN;

ACIDITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL COUNT; CELL ORGANELLE; CELL STRUCTURE; CELL SURVIVAL; CELL TRACKING; CELL VACUOLE; CELL VIABILITY; CELLULAR DISTRIBUTION; CYTOSOL; EMBRYO; LYSOSOME; MOUSE; NERVE CELL; NONHUMAN; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL EMBRYO; BAGG ALBINO MOUSE; BRAIN CORTEX; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TIME; TRANSGENIC MOUSE;

ADENINE; ANIMALS; AUTOPHAGY; BETA-CYCLODEXTRINS; CELLS, CULTURED; CEREBRAL CORTEX; CHOLESTEROL; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOMES; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; PROTEINS; TIME FACTORS; VACUOLES;

EID: 84908200577     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.10.006     Document Type: Article

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