RNA virus population diversity, an optimum for maximal fitness and virulence

Journal of Biological Chemistry

Volumn 289, Issue 43, 2014, Pages 29531-29544

  Korboukh, Victoria K ^a,c   Lee, Cheri A ^a   Acevedo, Ashley ^b   Vignuzzi, Marco ^b,d   Xiao, Yinghong ^b   Arnold, Jamie J ^a   Hemperly, Stephen ^a   Graci, Jason D ^a,e   August, Avery ^a,f   Andino, Raul ^b   Cameron, Craig E ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ASTRAZENECA   (United Kingdom)

^d INSTITUT PASTEUR   (France)

^e PTC THERAPEUTICS   (United States)

^f Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; MAMMALS; RNA;

ANTIVIRAL THERAPY; GENETIC DIVERSITY; IMMUNE RESPONSE; MOUSE MODELS; POPULATION GENETICS; RIBONUCLEOTIDES; SEQUENCING ANALYSIS; SUBSTANTIAL REDUCTION;

VIRUSES;

RNA DIRECTED RNA POLYMERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; IMMUNE RESPONSE; IN VITRO STUDY; MICROBIAL DIVERSITY; MOUSE; NONHUMAN; PARALYSIS; PHENOTYPE; POLIOMYELITIS VIRUS; POPULATION GENETICS; SEQUENCE ANALYSIS; VIRUS ATTENUATION; VIRUS GENOME; VIRUS MUTATION; VIRUS REPLICATION; VIRUS VIRULENCE; ANIMAL; ENZYMOLOGY; GENETICS; HELA CELL LINE; HUMAN; IMMUNITY; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PATHOGENICITY; POLIOMYELITIS; REPRODUCTIVE FITNESS; ULTRASTRUCTURE; VIROLOGY; VIRULENCE; VIRUS ASSEMBLY;

ANIMALS; BASE SEQUENCE; GENETIC FITNESS; GENOME, VIRAL; HELA CELLS; HUMANS; IMMUNITY; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; POLIOMYELITIS; POLIOVIRUS; RNA REPLICASE; VIRULENCE; VIRUS ASSEMBLY; VIRUS REPLICATION;

EID: 84908190429     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.592303     Document Type: Article

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