A conformational switch in collybistin determines the differentiation of inhibitory postsynapses

EMBO Journal

Volumn 33, Issue 18, 2014, Pages 2113-2133

  Soykan, Tolga ^a   Schneeberger, Daniela ^b   Tria, Giancarlo ^c,d   Buechner, Claudia ^b   Bader, Nicole ^b   Svergun, Dmitri ^c   Tessmer, Ingrid ^b   Poulopoulos, Alexandros ^a,e   Papadopoulos, Theofilos ^a   Varoqueaux, Frédérique ^a,f   Schindelin, Hermann ^b   Brose, Nils ^a  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d UNIVERSITY OF HAMBURG   (Germany)

^e Harvard University   (United States)

^f UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

autoinhibition; conformational activation; gephyrin; inhibitory synapse; neuroligin 2

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN COLLYBISTIN; GEPHYRIN; NEUROLIGIN; NEUROLIGIN 2; PHOSPHATIDYLINOSITIDE; UNCLASSIFIED DRUG; ARHGEF9 PROTEIN, MOUSE; CARRIER PROTEIN; MEMBRANE PROTEIN; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOCHEMICAL COMPOSITION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EMBRYO; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POSTSYNAPTIC INHIBITION; POSTSYNAPTIC MEMBRANE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ALLOSTERISM; ANIMAL; ATOMIC FORCE MICROSCOPY; AUTOINHIBITION; BIOLOGICAL MODEL; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATIONAL ACTIVATION; INHIBITORY SYNAPSE; METABOLISM; NEUROLIGIN-2; PHYSIOLOGY; SMALL ANGLE SCATTERING; SYNAPSE; X RAY CRYSTALLOGRAPHY;

AUTOINHIBITION; CONFORMATIONAL ACTIVATION; GEPHYRIN; INHIBITORY SYNAPSE; NEUROLIGIN-2;

ALLOSTERIC REGULATION; ANIMALS; CARRIER PROTEINS; CELL MEMBRANE; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; MEMBRANE PROTEINS; MICE; MICROSCOPY, ATOMIC FORCE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN CONFORMATION; RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS; SCATTERING, SMALL ANGLE; SYNAPSES;

EID: 84908179116     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201488143     Document Type: Article

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