Glycogen metabolism in cancer

Biochemical Pharmacology

Volumn 92, Issue 1, 2014, Pages 3-11

  Zois, Christos E ^b   Favaro, Elena ^a   Harris, Adrian L ^b  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cancer; Glycogen metabolism; Hypoxia; Pentose shunt

Indexed keywords

ADENOSINE PHOSPHATE; AMIDE; GLYCOGEN; INDOLE DERIVATIVE; PURINE NUCLEOSIDE DERIVATIVE;

CANCER CELL; CANCER INHIBITION; ENZYME ACTIVE SITE; GLYCOGEN METABOLISM; HUMAN; METABOLIC REGULATION; NEOPLASM; NONHUMAN; REVIEW; GENE EXPRESSION REGULATION; GLYCOGEN STORAGE DISEASE; METABOLISM; UPREGULATION;

GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN; GLYCOGEN STORAGE DISEASE; HUMANS; NEOPLASMS; UP-REGULATION;

EID: 84908152674     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.09.001     Document Type: Review

References (91)

1. M. DiNuzzo, S. Mangia, B. Maraviglia, and F. Giove Glycogenolysis in astrocytes supports blood-borne glucose channeling not glycogen-derived lactate shuttling to neurons: evidence from mathematical modeling J Cereb Blood Flow Metab 30 2010 1895 1904
2. I. Saez, J. Duran, C. Sinadinos, A. Beltran, O. Yanes, and M.F. Tevy Neurons have an active glycogen metabolism that contributes to tolerance to hypoxia J Cereb Blood Flow Metab 34 2014 945 955
3. K.R. Markan, M.J. Jurczak, and M.J. Brady Stranger in a strange land: roles of glycogen turnover in adipose tissue metabolism Mol Cell Endocrinol 318 2010 54 60
4. M. Rousset, A. Zweibaum, and J. Fogh Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins Cancer Res 41 1981 1165 1170
5. S. Takahashi, A. Satomi, K. Yano, H. Kawase, T. Tanimizu, and Y. Tuji Estimation of glycogen levels in human colorectal cancer tissue: relationship with cell cycle and tumor outgrowth J Gastroenterol 34 1999 474 480
6. I.J. Kurland, and S.J. Pilkis Indirect versus direct routes of hepatic glycogen synthesis FASEB J 3 1989 2277 2281
7. J.M. Berg, J.L. Tymoczko, and L. Stryer Biochemistry 2002 W.H. Freeman New York
8. P.J. Roach, A.A. Depaoli-Roach, T.D. Hurley, and V.S. Tagliabracci Glycogen and its metabolism: some new developments and old themes Biochem J 441 2012 763 787
9. R. Singh, and A.M. Cuervo Autophagy in the cellular energetic balance Cell Metab 13 2011 495 504
10. O.B. Kotoulas, S.A. Kalamidas, and D.J. Kondomerkos Glycogen autophagy in glucose homeostasis Pathol Res Pract 202 2006 631 638
11. S. Jiang, B. Heller, V.S. Tagliabracci, L. Zhai, J.M. Irimia, and A.A. DePaoli-Roach Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism J Biol Chem 285 2010 34960 34971
12. S. Jiang, C.D. Wells, and P.J. Roach Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1 Biochem Biophys Res Commun 413 2011 420 425
13. D. Stapleton, C. Nelson, K. Parsawar, M. Flores-Opazo, D. McClain, and G. Parker The 3T3-L1 adipocyte glycogen proteome Proteome Sci 11 2013 11
14. D. Stapleton, C. Nelson, K. Parsawar, D. McClain, R. Gilbert-Wilson, and E. Barker Analysis of hepatic glycogen-associated proteins Proteomics 10 2010 2320 2329
15. K.K. Rybicka Glycosomes - the organelles of glycogen metabolism Tissue Cell 28 1996 253 265
16. J. Duran, M.F. Tevy, M. Garcia-Rocha, J. Calbo, M. Milan, and J.J. Guinovart Deleterious effects of neuronal accumulation of glycogen in flies and mice EMBO Mol Med 4 2012 719 729
17. M.S. Gentry, C. Roma-Mateo, and P. Sanz Laforin, a protein with many faces: glucan phosphatase, adapter protein, et alii FEBS J 280 2013 525 537
18. J. Duran, A. Gruart, M. Garcia-Rocha, J.M. Delgado-Garcia, and J.J. Guinovart Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease Human Mol Genet 23 2014 3147 3156
19. N. Gaboriaud-Kolar, and A.L. Skaltsounis Glycogen phosphorylase inhibitors: a patent review (2008-2012) Expert Opin Ther Patents 23 2013 1017 1032
20. L. Agius Physiological control of liver glycogen metabolism: lessons from novel glycogen phosphorylase inhibitors Mini Rev Med Chem 10 2010 1175 1187
21. W.A. Loughlin Recent advances in the allosteric inhibition of glycogen phosphorylase Mini Rev Med Chem 10 2010 1139 1155
22. L. Agius New hepatic targets for glycaemic control in diabetes Best Pract Res Clin Endocrinol Metab 21 2007 587 605
23. S. Ros, M. Garcia-Rocha, J. Dominguez, J.C. Ferrer, and J.J. Guinovart Control of liver glycogen synthase activity and intracellular distribution by phosphorylation J Biol Chem 284 2009 6370 6378
24. J.C. Ferrer, C. Favre, R.R. Gomis, J.M. Fernandez-Novell, M. Garcia-Rocha, and N. de la Iglesia Control of glycogen deposition FEBS Lett 546 2003 127 132
25. R.R. Gomis, C. Favre, M. Garcia-Rocha, J.M. Fernandez-Novell, J.C. Ferrer, and J.J. Guinovart Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase J Biol Chem 278 2003 9740 9746
26. S. Munro, H. Ceulemans, M. Bollen, J. Diplexcito, and P.T. Cohen A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents FEBS J 272 2005 1478 1489
27. M.J. Doherty, G. Moorhead, N. Morrice, P. Cohen, and P.T. Cohen Amino acid sequence and expression of the hepatic glycogen-binding (GL)-subunit of protein phosphatase-1 FEBS Lett 375 1995 294 298
28. R. Halse, S.M. Bonavaud, J.L. Armstrong, J.G. McCormack, and S.J. Yeaman Control of glycogen synthesis by glucose, glycogen, and insulin in cultured human muscle cells Diabetes 50 2001 720 726
29. M. Bouskila, R.W. Hunter, A.F. Ibrahim, L. Delattre, M. Peggie, and J.A. van Diepen Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle Cell Metab 12 2010 456 466
30. G.M. Shen, F.L. Zhang, X.L. Liu, and J.W. Zhang Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia FEBS Lett 584 2010 4366 4372
31. K.W. Cheng, R. Agarwal, S. Mitra, J.S. Lee, M. Carey, and J.W. Gray Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress EMBO Mol Med 4 2012 125 141
32. C.V. Dang, A. Le, and P. Gao MYC-induced cancer cell energy metabolism and therapeutic opportunities Clin Cancer Res 15 2009 6479 6483
33. J. Luo Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy Cancer Lett 273 2009 194 200
34. L.K. Mamedova, V. Shneyvays, A. Katz, and A. Shainberg Mechanism of glycogen supercompensation in rat skeletal muscle cultures Mol Cell Biochem 250 2003 11 19
35. J. Pelletier, G. Bellot, P. Gounon, S. Lacas-Gervais, J. Pouyssegur, and N.M. Mazure Glycogen synthesis is induced in hypoxia by the hypoxia-inducible factor and promotes cancer cell survival Front Oncol 2 2012 18
36. N. Pescador, D. Villar, D. Cifuentes, M. Garcia-Rocha, A. Ortiz-Barahona, and S. Vazquez Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1 PLoS ONE 5 2010 e9644
37. A. Vigoda, L.K. Mamedova, V. Shneyvays, A. Katz, and A. Shainberg Glycogen metabolism in rat heart muscle cultures after hypoxia Mol Cell Biochem 254 2003 311 318
38. E. Favaro, K. Bensaad, M.G. Chong, D.A. Tennant, D.J. Ferguson, and C. Snell Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells Cell Metab 16 2012 751 764
39. D.R. Mole, C. Blancher, R.R. Copley, P.J. Pollard, J.M. Gleadle, and J. Ragoussis Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts J Biol Chem 284 2009 16767 16775
40. W.G. Kaelin Jr. Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein Cancer 115 2009 2262 2272
41. S. Camus, C. Quevedo, S. Menendez, I. Paramonov, P.F. Stouten, and R.A. Janssen Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish Oncogene 31 2012 4333 4342
42. W.N. Lee, P. Guo, S. Lim, S. Bassilian, S.T. Lee, and J. Boren Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment Br J Cancer 91 2004 2094 2100
43. D. Ma, J. Wang, Y. Zhao, W.N. Lee, J. Xiao, and V.L. Go Inhibition of glycogen phosphorylation induces changes in cellular proteome and signaling pathways in MIA pancreatic cancer cells Pancreas 41 2012 397 408
44. A. McBride, S. Ghilagaber, A. Nikolaev, and D.G. Hardie The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor Cell Metab 9 2009 23 34
45. J.P. Revel, L. Napolitano, and D.W. Fawcett Identification of glycogen in electron micrographs of thin tissue sections J Biophys Biochem Cytol 8 1960 575 589
46. M.J. Mc Histological and histochemical uses of periodic acid Stain Technol 23 1948 99 108
47. D. Cifuentes, C. Martinez-Pons, M. Garcia-Rocha, A. Galina, L. Ribas de Pouplana, and J.J. Guinovart Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver J Biol Chem 283 2008 5642 5649
48. R. Puri, N. Jain, and S. Ganesh Increased glucose concentration results in reduced proteasomal activity and the formation of glycogen positive aggresomal structures FEBS J 278 2011 3688 3698
49. C. Prats, A. Gomez-Cabello, P. Nordby, J.L. Andersen, J.W. Helge, and F. Dela An optimized histochemical method to assess skeletal muscle glycogen and lipid stores reveals two metabolically distinct populations of type I muscle fibers PLoS ONE 8 2013 e77774
50. O. Baba Production of monoclonal antibody that recognizes glycogen and its application for immunohistochemistry Kokubyo Gakkai Zasshi 60 1993 264 287
51. J. Hicks, E. Wartchow, and G. Mierau Glycogen storage diseases: a brief review and update on clinical features, genetic abnormalities, pathologic features, and treatment Ultrastruct Pathol 35 2011 183 196
52. J.V. Passonneau, and V.R. Lauderdale A comparison of three methods of glycogen measurement in tissues Anal Biochem 60 1974 405 412
53. M.C. Louzao, B. Espina, M.R. Vieytes, F.V. Vega, J.A. Rubiolo, and O. Baba Fluorescent glycogen formation with sensibility for in vivo and in vitro detection Glycoconj J 25 2008 503 510
54. T.H. Witney, L. Carroll, I.S. Alam, A. Chandrashekran, Q.D. Nguyen, and R. Sala A novel radiotracer to image glycogen metabolism in tumors by positron emission tomography Cancer Res 74 2014 1319 1328
55. L. Meijer, M. Flajolet, and P. Greengard Pharmacological inhibitors of glycogen synthase kinase 3 Trends Pharmacol Sci 25 2004 471 480
56. T. Kramer, B. Schmidt, and F. Lo Monte Small-molecule inhibitors of GSK-3: structural insights and their application to Alzheimer's disease models Int J Alzheimer's Dis 2012 2012 381029
57. F. Takahashi-Yanaga Activator or inhibitor? GSK-3 as a new drug target Biochem Pharmacol 86 2013 191 199
58. M. Arfeen, and P.V. Bharatam Design of glycogen synthase kinase-3 inhibitors: an overview on recent advancements Curr Pharm Des 19 2013 4755 4775
59. B. Viollet, S. Horman, J. Leclerc, L. Lantier, M. Foretz, and M. Billaud AMPK inhibition in health and disease Crit Rev Biochem Mol Biol 45 2010 276 295
60. R. Halse, L.G. Fryer, J.G. McCormack, D. Carling, and S.J. Yeaman Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase Diabetes 52 2003 9 15
61. T. Suzuki, D. Bridges, D. Nakada, G. Skiniotis, S.J. Morrison, and J.D. Lin Inhibition of AMPK catabolic action by GSK3 Mol Cell 50 2013 407 419
62. F. Giordanetto, and D. Karis Direct AMP-activated protein kinase activators: a review of evidence from the patent literature Expert Opin Ther Patents 22 2012 1467 1477
63. K.C. Fearon, D.J. Glass, and D.C. Guttridge Cancer cachexia: mediators, signaling, and metabolic pathways Cell Metab 16 2012 153 166
64. S. Kir, J.P. White, S. Kleiner, L. Kazak, P. Cohen, and V.E. Baracos Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia Nature 513 2014 100 104
65. N. McCarthy Cachexia: running on empty Nature Rev Cancer 14 2014 576 577
66. J.L. Treadway, P. Mendys, and D.J. Hoover Glycogen phosphorylase inhibitors for treatment of type 2 diabetes mellitus Expert Opin Investig Drugs 10 2001 439 454
67. L. Somsak, V. Nagya, Z. Hadady, T. Docsa, and P. Gergely Glucose analog inhibitors of glycogen phosphorylases as potential antidiabetic agents: recent developments Curr Pharm Des 9 2003 1177 1189
68. T. Barf Intervention of hepatic glucose production. Small molecule regulators of potential targets for Type 2 diabetes therapy Mini Rev Med Chem 4 2004 897 908
69. B.R. Henke, and S.M. Sparks Glycogen phosphorylase inhibitors Mini Rev Med Chem 6 2006 845 857
70. L. Somsak, K. Czifrak, M. Toth, E. Bokor, E.D. Chrysina, and K.M. Alexacou New inhibitors of glycogen phosphorylase as potential antidiabetic agents Curr Med Chem 15 2008 2933 2983
71. B. Andersen, A. Rassov, N. Westergaard, and K. Lundgren Inhibition of glycogenolysis in primary rat hepatocytes by 1,4-dideoxy-1,4-imino-d-arabinitol Biochem J 342 Pt 3 1999 545 550
72. P. Jakobsen, J.M. Lundbeck, M. Kristiansen, J. Breinholt, H. Demuth, and J. Pawlas Iminosugars: potential inhibitors of liver glycogen phosphorylase Bioorg Med Chem 9 2001 733 744
73. T. Latsis, B. Andersen, and L. Agius Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes Biochem J 368 2002 309 316
74. N. Bergans, W. Stalmans, S. Goldmann, and F. Vanstapel Molecular mode of inhibition of glycogenolysis in rat liver by the dihydropyridine derivative, BAY R3401: inhibition and inactivation of glycogen phosphorylase by an activated metabolite Diabetes 49 2000 1419 1426
75. M. Kristiansen, B. Andersen, L.F. Iversen, and N. Westergaard Identification, synthesis, and characterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site J Med Chem 47 2004 3537 3545
76. Z. Lu, J. Bohn, R. Bergeron, Q. Deng, K.P. Ellsworth, and W.M. Geissler A new class of glycogen phosphorylase inhibitors Bioorg Med Chem Lett 13 2003 4125 4128
77. T. Klabunde, K.U. Wendt, D. Kadereit, V. Brachvogel, H.J. Burger, and A.W. Herling Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes J Med Chem 48 2005 6178 6193
78. N.G. Oikonomakos, M.N. Kosmopoulou, E.D. Chrysina, D.D. Leonidas, I.D. Kostas, and K.U. Wendt Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs Protein Sci 14 2005 1760 1771
79. W.H. Martin, D.J. Hoover, S.J. Armento, I.A. Stock, R.K. McPherson, and D.E. Danley Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo Proc Natl Acad Sci U S A 95 1998 1776 1781
80. D.J. Hoover, S. Lefkowitz-Snow, J.L. Burgess-Henry, W.H. Martin, S.J. Armento, and I.A. Stock Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase J Med Chem 41 1998 2934 2938
81. V.L. Rath, M. Ammirati, P.K. LeMotte, K.F. Fennell, M.N. Mansour, and D.E. Danley Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core Mol Cell 6 2000 139 148
82. V.L. Rath, M. Ammirati, D.E. Danley, J.L. Ekstrom, E.M. Gibbs, and T.R. Hynes Human liver glycogen phosphorylase inhibitors bind at a new allosteric site Chem Biol 7 2000 677 682
83. N.G. Oikonomakos, V.T. Skamnaki, K.E. Tsitsanou, N.G. Gavalas, and L.N. Johnson A new allosteric site in glycogen phosphorylase b as a target for drug interactions Structure 8 2000 575 584
84. K.G. Rosauer, A.K. Ogawa, C.A. Willoughby, K.P. Ellsworth, W.M. Geissler, and R.W. Myers Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a Bioorg Med Chem Lett 13 2003 4385 4388
85. P.R. Whittamore, M.S. Addie, S.N. Bennett, A.M. Birch, M. Butters, and L. Godfrey Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies Bioorg Med Chem Lett 16 2006 5567 5571
86. A.M. Birch, P.W. Kenny, N.G. Oikonomakos, L. Otterbein, P. Schofield, and P.R. Whittamore Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors Bioorg Med Chem Lett 17 2007 394 399
87. S. Freeman, J.B. Bartlett, G. Convey, I. Hardern, J.L. Teague, and S.J. Loxham Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme Br J Pharmacol 149 2006 775 785
88. A. Kaiser, K. Nishi, F.A. Gorin, D.A. Walsh, E.M. Bradbury, and J.B. Schnier The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase Arch Biochem Biophys 386 2001 179 187
89. N.G. Oikonomakos, J.B. Schnier, S.E. Zographos, V.T. Skamnaki, K.E. Tsitsanou, and L.N. Johnson Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site J Biol Chem 275 2000 34566 34573
90. L.J. Hampson, C. Arden, L. Agius, M. Ganotidis, M.N. Kosmopoulou, and C. Tiraidis Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site Bioorg Med Chem 14 2006 7835 7845
91. S.Y. Lunt, and M.G. Vander Heiden Aerobic glycolysis: meeting the metabolic requirements of cell proliferation Annu Rev Cell Dev Biol 27 2011 441 464