Glycogenolysis in astrocytes supports blood-borne glucose channeling not glycogen-derived lactate shuttling to neurons: Evidence from mathematical modeling

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 12, 2010, Pages 1895-1904

  Dinuzzo, Mauro ^a   Mangia, Silvia ^b   Maraviglia, Bruno ^a,c   Giove, Federico ^a,d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^d MUSEO STORICO DELLA FISICA E CENTRO STUDI E RICERCHE ENRICO FERMI   (Italy)

Author keywords

brain glycogen; lactate shuttle; mathematical modeling; neurometabolic coupling; neuronal activation

Indexed keywords

GLUCOSE; GLUCOSE 6 PHOSPHATE; GLYCOGEN; HEXOKINASE; LACTIC ACID;

ARTICLE; ASTROCYTE; BRAIN DEPTH STIMULATION; BRAIN NERVE CELL; BRAIN TISSUE; GLYCOGEN METABOLISM; GLYCOGEN SYNTHESIS; GLYCOGENOLYSIS; MATHEMATICAL MODEL; PRIORITY JOURNAL;

ASTROCYTES; BLOOD GLUCOSE; GLYCOGEN; LACTIC ACID; MODELS, BIOLOGICAL; NEURONS;

EID: 78649708331     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.151     Document Type: Article

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