Morphine protects against methylmercury intoxication: A role for opioid receptors in oxidative stress?

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Costa Malaquias, Allan ^a   Almeida, Mauro B ^a   Souza Monteiro, José R ^a   Macchi, Barbarella De Matos ^a   Do Nascimento, JoséLuiz M ^a   Crespo Lopez, María Elena ^a  

^a FEDERAL UNIVERSITY OF PARÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLMERCURY; MORPHINE; MORPHINE SULFATE; NALOXONE; NITRITE; OPIATE; OPIATE RECEPTOR; THIOL GROUP; XENOBIOTIC AGENT; METHYLMERCURIC CHLORIDE; METHYLMERCURY DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SAFETY; DRUG TARGETING; GLIOMA CELL LINE; INTOXICATION; LIPID PEROXIDATION; MERCURIALISM; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; DRUG EFFECTS; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; HUMANS; LIPID PEROXIDATION; METHYLMERCURY COMPOUNDS; MORPHINE; NALOXONE; OXIDATION-REDUCTION; OXIDATIVE STRESS; RECEPTORS, OPIOID;

EID: 84908126121     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110815     Document Type: Article

References (46)

1. Ekstrom EB, Morel FM (2008) Cobalt limitation of growth and mercury methylation in sulfate-reducing bacteria. Environ Sci Technol 42: 93-99.
2. Harris HH, Pickering IJ, George GN (2003) The chemical form of mercury in fish. Science 301: 1203.
3. Berzas Nevado JJ, Rodriguez Martin-Doimeadios RC, Guzman Bernardo FJ, Jimenez Moreno M, Herculano AM, et al. (2010) Mercury in the Tapajos River basin, Brazilian Amazon: a review. Environ Int 36: 593-608.
4. Gibb H, O'Leary KG (2014) Mercury expoure and health impacts among individuals in the artisanal and small-scale gold mining community: a comprehensive review. Environ Health Perspect. doi: 10.289/ehp1307864.
5. Karagas MR, Choi AL, Oken E, Horvat M, Schoeny R, Kamai E, et al. (2012) Evidence on the human health effects of low-level methylmercury exposure. Environ Health Perspect 120(6): 799-806.
6. Rodriguez Martin-Doimeadios RC, Berzas Nevado JJ, Guzman Bernardo FJ, Jimenez Moreno M, Arrifano GP, et al. (2014) Comparative study of mercury speciation in commercial fishes of the Brazilian Amazon. Environ Sci Pollut Res Int. doi: 10.1007/s11356-014-2680-7.
7. do Nascimento JL, Oliveira KR, Crespo-Lopez ME, Macchi BM, Maues LA, et al. (2008) Methylmercury neurotoxicity & antioxidant defenses. Indian J Med Res 128: 373-382.
8. Carta P, Flore C, Alinovi R, Ibba A, Tocco MG, et al. (2003) Sub-clinical neurobehavioral abnormalities associated with low level of mercury exposure through fish consumption. Neurotoxicology 24: 617-623.
9. Crespo-Lopez ME, Lima de Sa A, Herculano AM, Rodriguez Burbano R, Martins do Nascimento JL (2007) Methylmercury genotoxicity: a novel effect in human cell lines of the central nervous system. Environ Int 33: 141-146.
10. Crespo-Lopez ME, Macedo GL, Arrifano GP, Pinheiro MC, do Nascimento JL, et al. (2011) Genotoxicity of mercury: contributing for the analysis of Amazonian populations. Environ Int 37: 136-141.
11. Crespo-Lopez ME, Macedo GL, Pereira SI, Arrifano GP, Picanco-Diniz DL, et al. (2009) Mercury and human genotoxicity: critical considerations and possible molecular mechanisms. Pharmacol Res 60: 212-220.
12. Nevado JJB, Martin-Doimeadios RCR, Moreno MJ, do Nascimento JLM, Herculano AM, et al. (2009) Mercury speciation analysis on cell lines of the human central nervous system to explain genotoxic effects. Microchem J 93: 12-16.
13. Aschner M, Syversen T, Souza DO, Rocha JB, Farina M (2007) Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity. Braz J Med Biol Res 40: 285-291.
14. Farina M, Avila DS, da Rocha JB, Aschner M (2013) Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury. Neurochem Int 62: 575-594.
15. Herculano AM, Crespo-Lopez ME, Lima SM, Picanco-Diniz DL, Do Nascimento JL (2006) Methylmercury intoxication activates nitric oxide synthase in chick retinal cell culture. Braz J Med Biol Res 39: 415-418.
16. Sen CK (1997) Nutritional biochemistry of cellular glutathione. J Nutr Biochem 8: 660-672.
17. Almeida MB, Costa-Malaquias A, Nascimento JL, Oliveira KR, Herculano AM, et al. (2014) Therapeutic concentration of morphine reduces oxidative stress in glioma cell line. Braz J Med Biol Res 47(5): 398-402.
18. Trescot AM, Helm S, Hansen H, Benyamin R, Glaser SE, et al. (2008) Opioids in the management of chronic non-cancer pain: an update of American Society of the Interventional Pain Physicians' (ASIPP) Guidelines. Pain Physician 11: S5-S62.
19. ICBN (2013) Report of the International Narcotics Control Board for 2012. New York: United Nations. pp. 146.
20. Bohn LM, Belcheva MM, Coscia CJ (1998) Evidence for kappa- and mu-opioid receptor expression in C6 glioma cells. J Neurochem 70: 1819-1825.
21. Kanesaki T, Saeki M, Ooi Y, Suematsu M, Matsumoto K, et al. (1999) Morphine prevents peroxynitrite-induced death of human neuroblastoma SHSY5Y cells through a direct scavenging action. Eur J Pharmacol 372: 319-324.
22. Gülc¸in ̄, Beydemir Ş, Alici A, Elmastaş M, Büyükokuroʇlu ME (2004) In vitro antioxidant properties of morphine. Pharmacol Res 49: 59-66.
23. Lee J, Kim MS, Park C, Jung EB, Choi DH, et al. (2004) Morphine prevents glutamate-induced death of primary rat neonatal astrocytes through modulation of intracellular redox. Immunopharmacol Immunotoxicol 26: 17-28.
24. Guzman DC, Vazquez IE, Brizuela NO, Alvarez RG, Mejia GB, et al. (2006) Assessment of oxidative damage induced by acute doses of morphine sulfate in postnatal and adult rat brain. Neurochem Res 31: 549-554.
25. Qian L, Tan KS, Wei SJ, Wu HM, Xu Z, et al. (2007) Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity. J Immunol 179: 1198-1209.
26. Ozmen I, Naziroglu M, Alici HA, Sahin F, Cengiz M, et al. (2007) Spinal morphine administration reduces the fatty acid contents in spinal cord and brain by increasing oxidative stress. Neurochem Res 32: 19-25.
27. Feng Y, Lu Y, Lin X, Gao Y, Zhao Q, et al. (2008) Endomorphins and morphine limit anoxia-reoxygenation-induced brain mitochondrial dysfunction in the mouse. Life Sci 82: 752-763.
28. Zhou J, Li Y, Yan G, Bu Q, Lv L, et al. (2011) Protective role of taurine against morphine-induced neurotoxicity in C6 cells via inhibition of oxidative stress. Neurotox Res 20: 334-342.
29. Rozisky JR, Laste G, de Macedo IC, Santos VS, Krolow R, et al. (2013) Neonatal morphine administration leads to changes in hippocampal BDNF levels and antioxidant enzyme activity in the adult life of rats. Neurochem Res 38: 494-503.
30. Abdel-Zaher AO, Mostafa MG, Farghaly HS, Hamdy MM, Abdel-Hady RH (2013) Role of oxidative stress and inducible nitric oxide synthase in morphineinduced tolerance and dependence in mice. Effect of alpha-lipoic acid. Behav Brain Res 247: 17-26.
31. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63.
32. 15N]nitrate in biological fluids. Anal Biochem 126: 131-138.
33. Bird RP, Draper HH (1984) Comparative studies on different methods of malonaldehyde determination. Methods Enzymol 105: 299-305.
34. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82: 70-77.
35. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
36. Belletti S, Orlandini G, Vettori MV, Mutti A, Uggeri J, et al. (2002) Time course assessment of methylmercury effects on C6 glioma cells: submicromolar concentrations induce oxidative DNA damage and apoptosis. J Neurosci Res 70: 703-711.
37. Kaur P, Evje L, Aschner M, Syversen T (2010) The in vitro effects of Trolox on methylmercury-induced neurotoxicity. Toxicology 276: 73-78.
38. Kaur P, Schulz K, Heggland I, Aschner M, Syversen T (2008) The use of fluorescence for detecting MeHg-induced ROS in cell cultures. Toxicol In Vitro 22: 1392-1398.
39. Sanfeliu C, Sebastia J, Ki SU (2001) Methylmercury neurotoxicity in cultures of human neurons, astrocytes, neuroblastoma cells. Neurotoxicology 22: 317-327.
40. Neumann PB, Henriksen H, Grosman N, Christensen CB (1982) Plasma morphine concentrations during chronic oral administration in patients with cancer pain. Pain 13: 247-252.
41. Yamashita T, Ando Y, Sakashita N, Hirayama K, Tanaka Y, et al. (1997) Role of nitric oxide in the cerebellar degeneration during methylmercury intoxication. Biochim Biophys Acta 1334: 303-311.
42. Farina M, Aschner M, Rocha JB (2011) Oxidative stress in MeHg-induced neurotoxicity. Toxicol Appl Pharmacol 256: 405-417.
43. Linden A, Gulden M, Martin HJ, Maser E, Seibert H (2008) Peroxide-induced cell death and lipid peroxidation in C6 glioma cells. Toxicol In Vitro 22: 1371-1376.
44. Ni M, Li X, Yin Z, Sidoryk-Wegrzynowicz M, Jiang H, et al. (2011) Comparative study on the response of rat primary astrocytes and microglia to methylmercury toxicity. Glia 59: 810-820.
45. Chang JY, Tsai PF (2008) Prevention of methylmercury-induced mitochondrial depolarization, glutathione depletion and cell death by 15-deoxy-delta-12,14- prostaglandin J(2). Neurotoxicology 29: 1054-1061.
46. Cookson MR, Pentreath VW (1996) Protective roles of glutathione in the toxicity of mercury and cadmium compounds to C6 glioma cells. Toxicol In Vitro 10: 257-264.