Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway

Cancer Research

Volumn 74, Issue 20, 2014, Pages 5914-5924

  Palmer, Colin J ^a   Galan Caridad, Jose M ^a,c   Weisberg, Stuart P ^a   Lei, Liang ^a   Esquilin, Jose M ^a,d   Croft, Gist F ^a   Wainwright, Brandon ^b   Canoll, Peter ^a   Owens, David M ^a   Reizis, Boris ^a  

^a Department of Medicine   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c IMS Consulting Group   (United States)

^d DRISCOLL CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXONUCLEASE; PROTEIN DIS3L; PROTEIN PATCHED 1; PROTEIN UBE2J1; PROTEIN ZFX; REGULATOR PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; UBIQUITIN CONJUGATING ENZYME E2; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; DIS3L PROTEIN, HUMAN; KRUPPEL LIKE FACTOR; PATCHED RECEPTORS; RIBONUCLEASE; UBE2J1 PROTEIN, HUMAN; UBIQUITIN CONJUGATING ENZYME; ZINC FINGER PROTEIN, X-LINKED;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL CELL CARCINOMA; CARCINOGENESIS; CHROMATIN IMMUNOPRECIPITATION; GENE DELETION; GENE EXPRESSION; GENETIC CONSERVATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; MEDULLOBLASTOMA; MEDULLOBLASTOMA CELL LINE; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; ANIMAL; CELL PROLIFERATION; CEREBELLUM TUMOR; GENE INACTIVATION; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SKIN TUMOR; TUMOR CELL LINE;

ANIMALS; CARCINOGENESIS; CARCINOMA, BASAL CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CEREBELLAR NEOPLASMS; GENE KNOCKOUT TECHNIQUES; HEDGEHOG PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MEDULLOBLASTOMA; MICE, KNOCKOUT; RECEPTORS, CELL SURFACE; RIBONUCLEASES; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; UBIQUITIN-CONJUGATING ENZYMES;

EID: 84908126107     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-0834     Document Type: Article

References (54)

1. Hooper JE, Scott MP. Communicating with Hedgehogs. Nat Rev Mol Cell Biol 2005;6:306-17.
2. Ingham PW, Nakano Y, Seger C. Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 2011;12: 393-406.
3. Lum L, Beachy PA. The Hedgehog Response Network: Sensors, Switches, and Routers. Science 2004;304:1755-9.
4. Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev 2008;22:2454-72.
5. Kenney AM, Cole MD, Rowitch DH. Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development 2003;130:15-28.
6. Wijgerde M, McMahon JA, Rule M, McMahon AP. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 2002;16:2849-64.
7. Dessaud E, McMahon AP, Briscoe J. Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 2008;135:2489-503.
8. Corrales JD, Blaess S, Mahoney EM, Joyner AL. The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development 2006;133:1811-21.
9. Dahmane N, Ruiz-i-Altaba A. Sonic hedgehog regulates the growth and patterning of the cerebellum. Development 1999;126:3089-100.
10. Lewis PM, Gritli-Linde A, Smeyne R, Kottmann A, McMahon AP. Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol 2004;270:393-410.
11. Chiang C, Swan RZ, Grachtchouk M, Bolinger M, Litingtung Y, Robertson EK, et al. Essential role for sonic hedgehog during hair follicle morphogenesis. Dev Biol 1999;205:1-9.
12. St-Jacques B, Dassule HR, Karavanova I, Botchkarev VA, Li J, Danielian PS, et al. Sonic hedgehog signaling is essential for hair development. Curr Biol 1998;8:1058-69.
13. Ng JMY, Curran T. The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer 2011;11:493-501.
14. Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer 2008;8:743-54.
15. Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, et al. Subtypes of medulloblastoma have distinct developmental origins. Nature 2010;468:1095-9.
16. Kool M, Koster J, Bunt J, Hasselt NE, Lakeman A, van Sluis P, et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS ONE 2008;3:e3088.
17. Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, Lau CC, et al. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 2006;24: 1924-31.
18. Goodrich LV, Milenkovic L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997;277:1109-13.
19. Adolphe C, Hetherington R, Ellis T, Wainwright B. Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res 2006;66:2081-8.
20. Schuller U, Heine VM, Mao J, Kho AT, Dillon AK, Han Y-G, et al. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form shh-induced medulloblastoma. Cancer Cell 2008;14:123-34.
21. Yang Z-J, Ellis T, Markant SL, Read T-A, Kessler JD, Bourboulas M, et al. Medulloblastoma can be initiated by deletion of patched in lineage-restricted progenitors or stem cells. Cancer Cell 2008;14: 135-45.
22. Wang GY, Wang J, Mancianti M-L, Epstein EH Jr. Basal cell carcinomas arise from hair follicle stem cells in Ptch1± mice. Cancer Cell 2011;19:114-24.
23. Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009;361:1173-8.
24. Von Hoff DD, LoRusso PM, Rudin CM, Reddy JC, Yauch RL, Tibes R, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009;361:1164-72.
25. Yauch RL, Dijkgraaf GJP, Alicke B, Januario T, Ahn CP, Holcomb T, et al. Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science 2009;326:572-4.
26. Kimura H, Ng JMY, Curran T. Transient inhibition of the hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell 2008;13:249-60.
27. Schneider-Gadicke A, Beer-Romero P, Brown LG, Mardon G, Luoh S-W, Page DC. Putative transcription activator with alternative isoforms encoded by human ZFX gene. Nature 1989;342:708-11.
28. Galan-Caridad JM, Harel S, Arenzana TL, Hou ZE, Doetsch FK, Mirny LA, et al. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 2007;129:345-57.
29. Harel S, Tu EY, Weisberg S, Esquilin M, Chambers SM, Liu B, et al. ZFX controls the self-renewal of human embryonic stem cells. PLoS ONE 2012;7:e42302.
30. Arenzana TL, Smith-Raska MR, Reizis B. Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes. Blood 2009;113:5857-67.
31. O'Donnell KA, Keng VW, York B, Reineke EL, Seo D, Fan D, et al. A sleeping beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer. Proc Natl Acad Sci 2012;109: E1377-E86.
32. Fang J, Yu Z, Lian M, Ma H, Tai J, Zhang L, et al. Knockdown of zinc finger protein, X-linked (ZFX) inhibits cell proliferation and induces apoptosis in human laryngeal squamous cell carcinoma. Mol Cell Biochem 2012;360:301-7.
33. Jiang H, Zhang L, Liu J, Chen Z, Na R, Ding G, et al. Knockdown of zinc finger protein X-linked inhibits prostate cancer cell proliferation and induces apoptosis by activating caspase-3 and caspase-9. Cancer Gene Ther 2012;19:684-9.
34. Zhou Y, Su Z, Huang Y, Sun T, Chen S, Wu T, et al. The Zfx gene is expressed in human gliomas and is important in the proliferation and apoptosis of the human malignant glioma cell line U251. J Exp Clin Cancer Res 2011;30:114.
35. Weisberg Stuart P, Smith-Raska Matthew R, Esquilin Jose M, Zhang J, Arenzana Teresita L, Lau Colleen M, et al. ZFX controls propagation and prevents differentiation of acute T-Lymphoblastic and myeloid leukemia. Cell Reports 2014;6:528-40.
36. Trotman LC, Niki M, Dotan ZA, Koutcher JA, Di Cristofano A, Xiao A, et al. Pten dose dictates cancer progression in the prostate. PLoS Biol 2003;1:e59.
37. Ellis T, Smyth I, Riley E, Graham S, Elliot K, Narang M, et al. Patched 1 conditional null allele in mice. Genesis 2003;36:158-61.
38. Zhuo L, Theis M, Alvarez-Maya I, Brenner M, Willecke K, Messing A. hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis 2001;31:85-94.
39. Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, et al. A novel somatic mouse model to survey tumorigenic potential applied to the hedgehog pathway. Cancer Res 2006;66: 10171-8.
40. Lei L, Sonabend AM, Guarnieri P, Soderquist C, Ludwig T, Rosenfeld S, et al. Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype. PLoS One 2011;6:e20041.
41. Sharov AA, Dudekula DB, Ko MSH. A web-based tool for principal component and significance analysis of microarray data. Bioinformatics 2005;21:2548-9.
42. Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008;133:1106-17.
43. Langmead B, Trapnell C, Pop M, Salzberg S. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol 2009;10:R25.
44. Zhang Y, Liu T, Meyer C, Eeckhoute J, Johnson D, Bernstein B, et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol 2008;9: R137.
45. Salmon-Divon M, Dvinge H, Tammoja K, Bertone P. Peak analyzer: genome-wide annotation of chromatin binding and modification loci. BMC Bioinformatics 2010;11:415.
46. Giannopoulou E, Elemento O. An integrated ChIP-seq analysis platform with customizable workflows. BMC Bioinformatics 2011;12:277.
47. Vidal VPI, Ortonne N, Schedl A. SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms. J Cutan Pathol 2008;35:373-9.
48. Pei Y, Moore Colin E, Wang J, Tewari Alok K, Eroshkin A, Cho Y-J, et al. An animal model of MYC-driven medulloblastoma. Cancer Cell 2012;21:155-67.
49. Northcott PA, Korshunov A, Witt H, Hielscher T, Eberhart CG, Mack S, et al. Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 2011;29:1408-14.
50. Staals RHJ, Bronkhorst AW, Schilders G, Slomovic S, Schuster G, Heck AJR, et al. Dis3-like 1: a novel exoribonuclease associated with the human exosome. EmedulloblastomaO J 2010;29:2358-67.
51. Tomecki R, Kristiansen MS, Lykke-Andersen S, Chlebowski A, Larsen KM, Szczesny RJ, et al. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. EmedulloblastomaO J 2010;29:2342-57.
52. Burr ML, Cano F, Svobodova S, Boyle LH, Boname JM, Lehner PJ. HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation. Proc Natl Acad Sci 2011;108:2034-9.
53. Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 2009;136:823-37.
54. Astuti D, Morris MR, Cooper WN, Staals RHJ, Wake NC, Fews GA, et al. Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility. Nat Genet 2012;44:277-84.