Knockdown of zinc finger protein X-linked inhibits prostate cancer cell proliferation and induces apoptosis by activating caspase-3 and caspase-9

Cancer Gene Therapy

Volumn 19, Issue 10, 2012, Pages 684-689

  Jiang, H ^a   Zhang, L ^b   Liu, J ^b   Chen, Z ^a   Na, R ^b   Ding, G ^b   Zhang, H ^a   Ding, Q ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN X LINKED;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; COLORIMETRY; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; CASPASE 3; CASPASE 9; CELL GROWTH PROCESSES; ENZYME ACTIVATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; PROSTATIC NEOPLASMS; ZINC FINGERS;

MAMMALIA;

EID: 84866405447     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2012.53     Document Type: Article

References (22)

1. Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61: 212-236.
2. Gronberg H. Prostate cancer epidemiology. Lancet 2003; 361: 859-864.
3. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275: 1943-1947.
4. Dong JT, Li CL, Sipe TW, Frierson Jr HF. Mutations of PTEN/MMAC1 in primary prostate cancers from Chinese patients. Clin Cancer Res 2001; 7: 304-308.
5. McCarty AS, Kleiger G, Eisenberg D, Smale ST. Selective dimerization of a C2H2 zinc finger subfamily. Mol Cell 2003; 11: 459-470.
6. Laity JH, Lee BM, Wright PE. Zinc finger proteins: new insights into structural and functional diversity. Curr Opin Struct Biol 2001; 11: 39-46.
7. Porteus MH, Carroll D. Gene targeting using zinc finger nucleases. Nat Biotechnol 2005; 23: 967-973.
8. Iwase M, Satta Y, Hirai Y, Hirai H, Imai H, Takahata N. The amelogenin loci span an ancient pseudoautosomal boundary in diverse mammalian species. Proc Natl Acad Sci USA 2003; 100: 5258-5263.
9. Poloumienko A. Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY. Genome 2004; 47: 74-83.
10. Luoh SW, Bain PA, Polakiewicz RD, Goodheart ML, Gardner H, Jaenisch R et al. Zfx mutation results in small animal size and reduced germ cell number in male and female mice. Development 1997; 124: 2275-2284.
11. Arenzana TL, Smith-Raska MR, Reizis B. Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes. Blood 2009; 113: 5857-5867.
12. Soneoka Y, Cannon PM, Ramsdale EE, Griffiths JC, Romano G, Kingsman SM et al. A transient three-plasmid expression system for the production of high titer retroviral vectors. Nucleic Acids Res 1995; 23: 628-633.
13. Sakoda T, Kasahara N, Hamamori Y, Kedes L. A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes. J Mol Cell Cardiol 1999; 31: 2037-2047.
14. Tiscornia G, Singer O, Verma IM. Production and purification of lentiviral vectors. Nat Protoc 2006; 1: 241-245.
15. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-408.
16. Tricoli JV, Bracken RB. ZFY gene expression and retention in human prostate adenocarcinoma. Genes Chromosomes Cancer 1993; 6: 65-72.
17. Galan-Caridad JM, Harel S, Arenzana TL, Hou ZE, Doetsch FK, Mirny LA et al. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 2007; 129: 345-357.
18. North M, Sargent C, O'Brien J, Taylor K, Wolfe J, Affara NA et al. Comparison of ZFY and ZFX gene structure and analysis of alternative 30 untranslated regions of ZFY. Nucleic Acids Res 1991; 19: 2579-2586.
19. Tucker PK, Adkins RM, Rest JS. Differential rates of evolution for the ZFY-related zinc finger genes, Zfy, Zfx, and Zfa in the mouse genus Mus. Mol Biol Evol 2003; 20: 999-1005.
20. Schneider-Gadicke A, Beer-Romero P, Brown LG, Nussbaum R, Page DC. ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation. Cell 1989; 57: 1247-1258.
21. Fang J, Yu Z, Lian M, Ma H, Tai J, Zhang L et al. Knockdown of zinc finger protein, X-linked (ZFX) inhibits cell proliferation and induces apoptosis in human laryngeal squamous cell carcinoma. Mol Cell Biochem 2012; 360: 301-307.
22. Kim DH, Behlke MA, Rose SD, Chang MS, Choi S, Rossi JJ. Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat Biotechnol 2005; 23: 222-226.