Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres

International Journal of Pharmaceutics

Volumn 334, Issue 1-2, 2007, Pages 137-148

  Mao, Shirui ^a,b   Xu, Jing ^a   Cai, Cuifang ^a,b   Germershaus, Oliver ^a   Schaper, Andreas ^a   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Burst release; Internal morphology; Microspheres; Poly(lactic co glycolic acid) (PLGA); Porosity

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE DEXTRAN; MICROSPHERE; POLYGLACTIN; POLYVINYL ALCOHOL;

ARTICLE; BIODEGRADABILITY; CONFOCAL LASER MICROSCOPY; DRUG COATING; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG RELEASE; HYDROPHILICITY; MACROMOLECULE; MICROEMULSION; MOLECULAR WEIGHT; PARTICLE SIZE; POLYMER PRODUCTION; POROSITY; PRIORITY JOURNAL; STEREOLOGY;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DEXTRANS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EMULSIONS; FLUORESCEIN-5-ISOTHIOCYANATE; LACTIC ACID; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MOLECULAR WEIGHT; OILS; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; POLYVINYL ALCOHOL; POROSITY; WATER;

EID: 33947188787     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.10.036     Document Type: Article

References (28)

1. Berkland C., King M., Cox A., Kim K., and Pack D.W. Precise control of PLG microsphere size provides enhanced control of drug release rate. J. Controlled Release 82 (2002) 137-147
2. Bittner B., Witt C., Mader K., and Kissel T. Degradation and protein release properties of microspheres prepared from biodegradable poly(lactide-co-glycolide) and ABA triblock copolymers: influence of buffer media on polymer erosion and bovine serum albumin release. J. Controlled Release 60 (1999) 297-309
3. Bodmer D., Kissel T., and Traechslin E. Factors influencing the release of peptides and proteins from biodegradable parenteral depot systems. J. Controlled Release 2 (1992) 129-138
4. Brunner A., Mäder K., and Göpferich A. pH and osmotic pressure inside biodegradable microspheres during erosion. Pharm. Res. 16 (1999) 847-853
5. Burke P.A. Determination of internal pH in PLGA microspheres using 31P NMR spectroscopy. Proc. Int. Symp. Control. Rel. Bioact. Mater. 23 (1996) 133-134
6. Capan Y., Woo B.H., Gebrekidan S., Ahmed S., and DeLuca P.P. Influence of formulation parameters on the characteristics of poly(d,l-lactide-co-glycolide) microspheres containing poly(l-lysine) complexed plasmid DNA. J. Controlled Release 60 (1999) 279-286
7. Ehtezazi T., Washington C., and Melia C.D. Determination of the internal morphology of poly (d,l-lactide) microspheres using stereological methods. J. Controlled Release 57 (1999) 301-314
8. Ehtezazi T., Washington C., and Melia C.D. First order release rate from porous PLA microspheres with limited exit holes on the exterior surface. J. Controlled Release 66 (2000) 27-38
9. Ghaderi R., Sturesson C., and Carlfors J. Effect of preparative parameters on the characteristics of poly(d,l-lactide-co-glycolide) microspheres made by the double emulsion method. Int. J. Pharm. 141 (1996) 205-216
10. Jain R.A. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 21 (2000) 2475-2490
11. Jalil R., and Nixon J.R. Microencapsulation using poly(l-lactic acid) II: preparative variables affecting microcapsule properties. J. Microencapsulation 7 (1990) 25-39
12. Jalil R., and Nixon J.R. Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties. J. Microencapsulation 7 (1990) 297-325
13. Jiang W., Gupta R.K., Deshpande M.C., and Schwendeman S.P. Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens. Adv. Drug Deliv. Rev. 57 (2005) 391-410
14. Freiberg S., and Zhu X. Polymer microspheres for controlled drug release. Int. J. Pharm. 282 (2004) 1-18
15. Kim H.K., and Park T.G. Comparative study on sustained release of human growth hormone from semi-crystalline poly(l-lactic acid) and amorphous poly(d,l-lactic-co-glycolic acid) microspheres: morphological effect on protein release. J. Controlled Release 98 (2004) 115-125
16. Li W.I., Anderson K.W., Mehta R.C., and Deluca P.P. Kinetic and thermodynamic modeling of the formation of polymeric microspheres using solvent extraction/evaporation method. J. Controlled Release 37 (1995) 187-198
17. Li L., and Schwendeman S.P. Mapping neutral microclimate pH in PLGA microspheres. J. Controlled Release 101 (2005) 163-173
18. O'Donnell P.B., and McGinity J.W. Preparation of microspheres by the solvent evaporation technique. Adv. Drug Deliv. Rev. 28 (1997) 25-42
19. Painbeni T., Venier-Julienne M.C., and Benoit J.P. Internal morphology of poly (d,l-lactide-co-glycolide) BCNU-loaded microspheres. Influence on drug stability. Eur. J. Pharm. Biopharm. 45 (1998) 31-39
20. Pistel K.F., Breitenbach A., Zange-Volland R., and Kissel T. Brush-like branched biodegradable polyesters, part III. Protein release from microspheres of poly(vinyl alcohol)-graft-poly(d,l-lactic-co-glycolic acid). J. Controlled Release 73 (2001) 7-20
21. Rothen-Weinhold A., Besseghir K., and Gurny R. Analysis of the influence of polymer characteristics and core loading on the in vivo release of a somatostatin analogue. Eur. J. Pharm. Sci. 5 (1997) 303-313
22. Sandor M., Enscore D., Weston P., and Mathiowitz E. Effect of protein molecular weight on release from micron-sized PLGA microspheres. J. Controlled Release 76 (2001) 297-311
23. Schlicher E.J.A.M., Postma N.S., Zuidema J., Talsma H., and Hennink W.E. Preparation and characterization of poly(d,l-lactic-co-glycolic acid) microspheres containing desferrioxamine. Int. J. Pharm. 153 (1997) 235-245
24. Sinha V.R., and Trehan A. Biodegradable microspheres for protein delivery. J. Controlled Release 90 (2003) 261-280
25. Sturesson C., Carlfors J., Edsman K., and Andersson M. Preparation of biodegradable poly(lactide-go-glycolic) acid microspheres and their in vitro release of timolol maleate. Int. J. Pharm. 89 (1993) 235-244
26. Wang J., Wang B.M., and Schwendeman S.P. Characterization of the initial burst release of a model peptide from poly(d,l-lactide-co-glycolide) microspheres. J. Controlled Release 82 (2002) 289-307
27. Yang Y.Y., Chung T.S., and Ng N.P. Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. Biomaterials 22 (2001) 231-241
28. Yang Y.Y., Chia H.H., and Chung T.S. Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. J. Controlled Release 69 (2000) 81-96