Identification of self-antigen-specific T cells reflecting loss of tolerance in autoimmune disease underpins preventative immunotherapeutic strategies in rheumatoid arthritis

Rheumatic Disease Clinics of North America

Volumn 40, Issue 4, 2014, Pages 735-752

  Law, Soi Cheng ^a   Benham, Helen ^a   Reid, Hugh H ^b   Rossjohn, Jamie ^b,c   Thomas, Ranjeny ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

HLA susceptibility; Immune tolerance; PMHC tetramers; Regulatory T cells; Rheumatoid arthritis; Type 1 diabetes

Indexed keywords

CD45RO ANTIGEN; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; EPITOPE; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; HLA DRB1 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; TETRAMER; TRANSCRIPTION FACTOR FOXP3; AUTOANTIGEN; HLA-DRB1*04:01 ANTIGEN;

ANTIGEN PRESENTATION; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; COLLAGEN-INDUCED ARTHRITIS; DISEASE ACTIVITY; ENDOPLASMIC RETICULUM STRESS; EPITOPE MAPPING; GENETIC SUSCEPTIBILITY; HIGH RISK POPULATION; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENESIS; REGULATORY T LYMPHOCYTE; REVIEW; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; ANIMAL; ARTHRITIS, RHEUMATOID; EARLY INTERVENTION; GENETICS; IMMUNOLOGY;

ANIMALS; ARTHRITIS, RHEUMATOID; AUTOANTIGENS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; EARLY MEDICAL INTERVENTION; HLA-DRB1 CHAINS; HUMANS; SELF TOLERANCE;

EID: 84908067548     PISSN: 0889857X     EISSN: 15583163     Source Type: Journal    
DOI: 10.1016/j.rdc.2014.07.015     Document Type: Review

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