Intrinsic disorder as a generalizable strategy for the rational design of highly responsive, allosterically cooperative receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 42, 2014, Pages 15048-15053

  Simon, Anna J ^a   Vallée Bélisle, Alexis ^b   Ricci, Francesco ^c   Plaxco, Kevin W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Biosensors; Intrinsically disordered proteins; Ribozymes; Synthetic biology; Ultrasensitivity

Indexed keywords

APTAMER; INTRINSICALLY DISORDERED PROTEIN; RIBOZYME; 6-CARBOXYFLUORESCEIN; COCAINE; DNA; DOXORUBICIN; FLUORESCEIN DERIVATIVE; LIGAND; OXYGEN; PROTEIN BINDING;

ALLOSTERISM; ARTICLE; BIOSENSOR; HILL COEFFICIENT; RECEPTOR BINDING; SYNTHETIC BIOLOGY; TANDEM REPEAT; BINDING SITE; BIOTECHNOLOGY; CHEMISTRY; GENETIC PROCEDURES; PROCEDURES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FOLDING; SPECTROFLUOROMETRY;

ALLOSTERIC SITE; BIOSENSING TECHNIQUES; BIOTECHNOLOGY; COCAINE; DNA; DOXORUBICIN; FLUORESCEINS; LIGANDS; OXYGEN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FOLDING; RNA, CATALYTIC; SPECTROMETRY, FLUORESCENCE; SYNTHETIC BIOLOGY;

EID: 84908061195     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1410796111     Document Type: Article

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