Phenotypic shift of adipocytes by cholecalciferol and 1α,25 dihydroxycholecalciferol in relation to inflammatory status and calcium content

Endocrinology (United States)

Volumn 155, Issue 11, 2014, Pages 4178-4188

  Zoico, Elena ^a   Franceschetti, Guido ^a   Chirumbolo, Salvatore ^a   Rossi, Andrea P ^a   Mazzali, Gloria ^a   Rizzatti, Vanni ^a   Budui, Simona ^a   Zamboni, Mauro ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CALCIUM; CHOLESTANETRIOL 26 MONOOXYGENASE; COLECALCIFEROL; CYP27B1 ENZYME; CYTOCHROME P450; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VITAMIN D; AUTACOID;

ADIPOCYTE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL SIZE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HYDROXYLATION; IN VITRO STUDY; OPTICAL DENSITY; PHENOTYPE; PREMEDICATION; PROADIPOCYTE; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; 3T3 CELL LINE; ANIMAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; INFLAMMATION; METABOLISM; MOUSE; PHYSIOLOGY;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CALCITRIOL; CALCIUM; CHOLECALCIFEROL; GENE EXPRESSION REGULATION; INFLAMMATION; INFLAMMATION MEDIATORS; METABOLIC NETWORKS AND PATHWAYS; MICE; PHENOTYPE;

EID: 84908052445     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1969     Document Type: Article

References (43)

1. Weisberg SP1, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;12:1796-1808.
2. Wellen KE. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest. 2003;112:1785-1788.
3. Fleming KH, Heimbach JB. Consumption of Calcium in the U.S.: Food sources and intake levels. J Nutr. 1994;124(8 Suppl):1426S-1430S.
4. Zemel MB. Mechanisms of dairy modulation of adiposity. J Nutr. 2003;133:252S-256S.
5. Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC. Regulation of adiposity by dietary calcium. FASEB J. 2000;14:1132-1138.
6. Mai XM, Chen Y, Camargo CA Jr, Langhammer A. Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: The HUNT study. Am J Epidemiol. 2012;175:1029-1036.
7. Sun X, Zemel MB. Calcium and 1,25-dihydroxyvitamin D3 regulation of adipokine expression. Obesity. 2007;15:340-348.
8. Sun X, Zemel MB. Calcitriol and calcium regulate cytokine production and adipocyte-macrophage cross-talk. J Nutr Biochem. 2008;19:392-399.
9. Lira FS, Rosa JC, Cunha CA, et al. Supplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation. Lipids Health Dis. 2011;10:37.
10. Lorente-Cebrián S, Eriksson A, Dunlop T, et al. Differential effects of 1α,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes. Eur J Nutr. 2012;51:335-342.
11. Gao D, Trayhurn P, Bing C. 1,25-Dihydroxyvitamin D(3) inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment byhumanpreadipocytes. Int JObes. 2012;37:357-365.
12. Marcotorchino J, Gouranton E, Romier B, et al. Vitamin D reduces the inflammatory response and restores glucose uptake in adipocytes. Mol Nutr Food Res. 2012;56:1771-1782.
13. Adams JS, Hewison M. Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase. Arch Biochem Biophy. 2012;523:95-102.
14. Li J, Byrne ME, Chang E, et al. 1α,25-Dihydroxyvitamin D hydroxylase in adipocytes. J Steroid Biochem Mol Biol. 2008;112:122-126.
15. Sakaki T, Kagawa N, Yamamoto K, Inouye K. Metabolism of vitamin D3 by cytochromes P450. Front Biosci. 2005;10:119-134.
16. Wamberg L, Christiansen T, Paulsen SK, et al. Expression of vitamin D-metabolizing enzymes in human adipose tissue-the effect of obesity and diet-induced weight loss. Int J Obes. 2012;37:651-657.
17. Kong J, Li YC. Molecular mechanism of 1,25-dihydroxyvitamin D3 inhibition of adipogenesis in 3T3-L1 cells. Am J Physiol Endocrinol Metab. 2006;290:E916-E924.
18. Hida Y, Kawada T, Kayahashi S, Ishihara T, Fushiki T. Counteraction of retinoic acid and 1,25-dihydroxyvitamin D3 on up-regulation of adipocyte differentiation with PPARgamma ligand, an antidiabetic thiazolidinedione, in 3T3-L1 cells. Life Sci. 1998;62:PL205-PL211.
19. Wood RJ. Vitamin D and adipogenesis: New molecular insights. Nutr Rev. 2008;66:40-46.
20. Song Q, Sergeev IN. Calcium and vitamin D in obesity. Nutr Res Rev. 2012;25:130-141.
21. Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev. 2005;26:662-687.
22. Négrel R, Grimaldi P, Forest C, Ailhaud G. Establishment and characterization of fibroblast-like cell lines derived from adipocytes with the capacity to redifferentiate into adipocyte-like cells. Methods Enzymol. 1985;109:377-385.
23. Blankenship JR, Heitman J. Calcineurin is required for Candida albicans to survive calcium stress in serum. Infect Immun. 2005;73:5767-5774.
24. Rizzatti V, Boschi F, Pedrotti M, Zoico E, Sbarbati A, Zamboni M. Lipid droplets characterization in adipocyte differentiated 3T3-L1 cells: Size and optical density distribution. Eur J Histochem. 2013;57:e24.
25. Wang Q, Li H, Xie H, et al. 25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice. J Steroid Biochem Mol Biol. 2013;135:43-50.
26. Li H, Xie H, Fu M, et al. 25-hydroxyvitamin D3 ameliorates periodontitis by modulating the expression of inflammation-associated factors in diabetic mice. Steroids. 2013;78:115-120.
27. Coppack SW. Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc. 2001;60:349-356.
28. Wang Y, Wang H, Hedge V, et al. Interplay of pro- and anti-inflammatory cytokines to determine lipid accretion in adipocytes. Int J Obes. 2013;1-9.
29. Zoico E, Garbin U, Olioso D, et al. The effects of adiponectin on interleukin-6 and MCP-1 secretion in lipopolysaccharide-treated 3T3-L1 adipocytes: Role of the NF-κB pathway. Int J Mol Med. 2009;24:847-851.
30. Zhu JG, Ochalek JT, Kaufmann M, Jones G, Deluca HF. CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo. Proc Natl Acad Sci U S A. 2013;110:15650-15655.
31. Nimitphong H, Holick MF, Fried SK, Lee MJ. 25-Hydroxyvitamin D3 and 1,25-Dihydroxyvitamin D3 promote the differentiation of human subcutaneous preadipocytes. PLoS ONE. 2012;7:e52171.
32. Lou YR, Molnár F, Peräkylä M, et al. 25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand. J Steroid Biochem Mol Biol. 2010;118:162-170.
33. Chen TC, Persons KS, Lu Z, Mathieu JS, Holick MF. An evaluation of the biologic activity and vitamin D receptor binding affinity of the photoisomers of vitamin D3 and previtamin D3. J Nutr Biochem. 2000;11:267-272.
34. Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW. De-orphanization of cytochrome P450 2R1: A microsomal vitamin D 25-hydroxilase. J Biol Chem. 2003;278:38084-38093.
35. Konige M, Wang H, Sztalryd C. Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis. Biochim Biophys Acta. 2014;1842:393-401.
36. Dugail I. Lipids in metabolic diseases. Biochimie. 2014;96:1-2.
37. McLaughlin T, Sherman A, Tsao P, et al. Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis. Diabetologia. 2007;50:1707-1715.
38. Narvaez CJ, Matthews D, Broun E, Chan M, Welsh J. Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue. Endocrinology. 2009;150:651-661.
39. Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M. Calcitriol attenuates weight-related systemic inflammation and ultrastructural changes in the liver in a rodent model. Basic Clin Pharmacol Toxicol. 2013;112:42-49.
40. Calle C, Maestro B, Garcia-Arenciba M. Genomic actions of 1,25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats. BMC Mol Biol. 2008;9:65.
41. Shi H, Norman AW, Okamura WH, Sen A, Zemel MB. 1α,25-Dihydroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action. FASEB J. 2001;15:2751-2753.
42. 3 that resists the catalytic activity of both CYP27B1 and CYP24A1. J Cell Biochem. 2014;115:1392-1402.
43. 2+ -mediated apoptosis in adipocytes via activation of calpain and caspase-12. Biochem Biophys Res Commun. 2009;384:18-21.