Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes in the Liver in a Rodent Model

Basic and Clinical Pharmacology and Toxicology

Volumn 112, Issue 1, 2013, Pages 42-49

  Alkharfy, Khalid M ^a,b   Al Daghri, Nasser M ^b,c   Yakout, Sobhy M ^b,c   Ahmed, Mukhtar ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; C REACTIVE PROTEIN; CALCITRIOL; FAT DROPLET; INSULIN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BLOOD SAMPLING; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; HISTOPATHOLOGY; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LIVER CELL; LIVER PROTECTION; LIVER WEIGHT; LOW FAT DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WEIGHT CHANGE;

ANIMALS; BODY WEIGHT; CALCITRIOL; DIET, HIGH-FAT; INFLAMMATION; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL;

ANIMALIA; MUS; RODENTIA;

EID: 84871131538     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2012.00936.x     Document Type: Article

References (39)

1. Sandgren ME, Bronnegard M, DeLuca HF. Tissue distribution of the 1, 25-dihydroxyvitamin D3 receptor in the male rat. Biochem Biophys Res Commun 1991;181:611-6.
2. Mee AP, Davenport LK, Hoyland JA, Davies M, Mawer EB. Novel and sensitive detection systems for the vitamin D receptor-in situ-reverse transcriptase-polymerase chain reaction and immunogold cytochemistry. J Mol Endocrinol 1996;16:183-95.
3. George N, Peeyush Kumar T, Antony S, Jayanarayanan S, Paulose CS. Effect of vitamin D3 in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats. Br J Nutr 2012;6:1-9.
4. Takeyama K, Masuhiro Y, Fuse H, Endoh H, Murayama A, Kitanaka S et al. Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog. Mol Cell Biol 1999;19:1049-55.
5. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004;80:1678S-88S.
6. van Etten E, Mathieu C. Immunoregulation by 1, 25-dihydroxyvitamin D3: Basic concepts. J Steroid Biochem Mol Biol 2005;97:93-101.
7. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007;92:2017-29.
8. Norman AW, Frankel JB, Heldt AM, Grodsky GM. Vitamin d deficiency inhibits pancreatic secretion of insulin. Science 1980;209:823-5.
9. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis d is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004;79:820-5.
10. Sooy K, Schermerhorn T, Noda M, Surana M, Rhoten WB, Meyer M et al. Calbindin-d(28k) controls [ca(2 +)](i) and insulin release. Evidence obtained from calbindin-d(28k) knockout mice and beta cell lines. J Biol Chem 1999;274:34343-9.
11. Pittas AG, Dawson-Hughes B, Li T, Van Dam RM, Willett WC, Manson JE et al. Vitamin d and calcium intake in relation to type 2 diabetes in women. Diabetes Care 2006;29:650-6.
12. Davidson MB, Kaplan SA. Increased insulin binding by hepatic plasma membranes from diabetic rats: Normalization by insulin therapy. J Clin Invest 1977;59:22-30.
13. Kadowaki T, Kasuga M, Akanuma Y, Ezaki O, Takaku F. Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats. J Biol Chem 1984;259:14208-16.
14. Tozzo E, Desbuquois B. Effects of stz-induced diabetes and fasting on insulin receptor mrna expression and insulin receptor gene transcription in rat liver. Diabetes 1992;41:1609-16.
15. Amessou M, Bortoli S, Liemans V, Collinet M, Desbuquois B, Brichard S et al. Treatment of streptozotocin-induced diabetic rats with vanadate and phlorizin prevents the over-expression of the liver insulin receptor gene. Eur J Endocrinol 1999;140:79-86.
16. Calle C, Maestro B, Garcia-Arencibia M. Genomic actions of 1, 25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats. BMC Mol Biol 2008;9:65.
17. Tataranni PA, Ortega E. A burning question: Does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes? Diabetes 2005;54:917-27.
18. Franks PW. Obesity, inflammatory markers and cardiovascular disease: Distinguishing causality from confounding. J Hum Hypertens 2006;20:837-40.
19. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006;17:4-12.
20. Ridker P, Hennekens C, Buring J, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836-43.
21. Balistreri CR, Caruso C, Candore G. The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm 2010;802078:1-19.
22. Huffman DM, Barzilai N. Role of visceral adipose tissue in aging. Biochim Biophys Acta 2009;1790:1117-23.
23. Astrup A, Buemann B, Western P, Toubro S, Raben A, Christensen NJ. Obesity as an adaptation to a high-fat diet: evidence from a cross-sectional study. Am J Clin Nutr 1994;59:350-5.
24. Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J et al. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 2001;108:437-46.
25. Sims EA. Storage and expenditure of energy in obesity and their implications for management. Med Clin North Am 1989;73:97-110.
26. Ahren B. Plasma leptin and insulin in c57bi/6j mice on a high-fat diet: Relation to subsequent changes in body weight. Acta Physiol Scand 1999;165:233-40.
27. Reyenolds ES. The use of lead citrate at high ph as an electron opaque stain in electron microscopy. J Cell Biol 1963;17:208.
28. Wu CC, Chang JH, Chen CC, Su SB, Yang LK, Ma WY et al. Calcitriol treatment attenuates inflammation and oxidative stress in hemodialysis patients with secondary hyperparathyroidism. Tohoku J Exp Med 2011;223:153-9.
29. Ortega RM, Aparicio A, Rodriguez-Rodriguez E, Bermejo LM, Perea JM, Lopez-Sobaler AM et al. Preliminary data about the influence of vitamin D status on the loss of body fat in young overweight/obese women following two types of hypocaloric diet. Br J Nutr 2008;100:269-72.
30. Major GC, Alarie F, Dore J, Phouttama S, Tremblay A. Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations. Am J Clin Nutr 2007;85:54-9.
31. Ahren B, Simonsson E, Scheurink AJ, Mulder H, Myrsen U, Sundler F. Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in c57bl/6j mice. Metabolism 1997;46:97-106.
32. Hamza N, Berke B, Cheze C, Agli AN, Robinson P, Gin H et al. Prevention of type 2 diabetes induced by high fat diet in the c57bl/6j mouse by two medicinal plants used in traditional treatment of diabetes in the east of algeria. J Ethnopharmacol 2010;128:513-8.
33. Li YC. The role of vitamin D in chronic renal failure, US Renal Disease. http://www.touchbriefings.com/pdf/2173/chun.pdf 2006 (last accessed on 20 March 2012).
34. Barchetta I, Angelico F, Del Ben M, Baroni MG, Pozzilli P, Morini S et al. Strong association between non alcoholic fatty liver disease (nafld) and low 25(oh) vitamin D levels in an adult population with normal serum liver enzymes. BMC Med 2011;9:85.
35. Dickie LJ, Church LD, Coulthard LR, Mathews RJ, Emery P, McDermott MF. Vitamin d3 down-regulates intracellular toll-like receptor 9 expression and toll-like receptor 9-induced il-6 production in human monocytes. Rheumatology (Oxford) 2010;49:1466-71.
36. Kiki I, Altunkaynak BZ, Altunkaynak ME, Vuraler O, Unal D, Kaplan S. Effect of high fat diet on the volume of liver and quantitative feature of kupffer cells in the female rat: a stereological and ultrastructural study. Obes Surg 2007;17:1381-8.
37. Altunkaynak BZ, Ozbek E. Overweight and structural alterations of the liver in female rats fed a high-fat diet: A stereological and histological study. Turk J Gastroenterol 2009;20:93-103.
38. Zhu J, Lu K, Zhang C, Liang J, Hu Z. Biochemical and ultrastructural changes in the hepatopancreas of bellamya aeruginosa (gastropoda) fed with toxic cyanobacteria. Sci World J 2011;11:2091-105.
39. Natarajan SK, Eapen CE, Pullimood AB, Balasubramanian KA. Oxidative stress in experimental liver microvesicular steatosis: role of mitochondria and peroxisomes. J Gastroenterol Hepatol 2006;21:1240-9.