Increased REM sleep after intra-locus coeruleus nucleus microinjection of melanin-concentrating hormone (MCH) in the rat

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 56, Issue , 2015, Pages 185-188

  Monti, Jaime M ^a   Lagos, Patricia ^a   Jantos, Héctor ^a   Torterolo, Pablo ^a  

^a DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

Author keywords

Locus coeruleus; Melanin concentrating hormone; Noradrenaline; REM sleep; Sleep

Indexed keywords

MELANIN CONCENTRATING HORMONE; HYPOPHYSIS HORMONE; HYPOTHALAMUS HORMONE; MELANIN; MELANIN-CONCENTRATING HORMONE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HISTOLOGY; LATENT PERIOD; LOCUS CERULEUS; MALE; NONHUMAN; RAT; REM SLEEP; SLEEP WAKING CYCLE; ANALYSIS OF VARIANCE; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; MICROINJECTION; PHYSIOLOGY; REACTION TIME; WAKEFULNESS; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOTHALAMIC HORMONES; LOCUS COERULEUS; MALE; MELANINS; MICROINJECTIONS; PITUITARY HORMONES; RATS; RATS, WISTAR; REACTION TIME; SLEEP, REM; WAKEFULNESS;

EID: 84908045030     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2014.09.003     Document Type: Article

References (22)

1. Berridge C.W., Schmeichel B.E., España R.A. Noradrenergic modulation of wakefulness/arousal. Sleep Med Rev 2012, 16:187-197.
2. Bittencourt J.C. Anatomical organization of the melanin-concentrating hormone peptide family in the mammalian brain. Gen Comp Endocrinol 2011, 172:185-197.
3. Bittencourt J.C., Elias C.F. Melanin-concentrating hormone and neuropeptide EI projections from the lateral hypothalamic area and zona incerta to the medial septal nucleus and spinal cord: a study using multiple neuronal tracers. Brain Res 1998, 805:1-19.
4. Cryan J.F., Markou A., Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 2002, 23:238-245.
5. Del Cid-Pellitero E., Jones B.E. Immunohistochemical evidence for synaptic release of GABA from MCH-containing varicosities in the locus coeruleus. Neuroscience 2012, 223:269-276.
6. Detke M.J., Rickels M., Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl) 1995, 121:66-72.
7. Elias C.F., Lee C.E., Kelly J.F., Ahima R.S., Kuhar M., Saper C.B., et al. Characterization of CART neurons in the rat human hypothalamus. J Comp Neurol 2001, 432:1-19.
8. Gao X.B., Van Den Pol A.N. Melanin-concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus. J Physiol 2001, 533:237-252.
9. Harthoorn L.F. Projection-dependent differentiation of melanin-concentrating hormone-containing neurons. Cell Mol Neurobiol 2007, 27:49-55.
10. Hervieu G.J., Cluderay J.E., Harrison D., Meakin J., Maycox P., Nasir S., et al. The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene slc-1, in the central nervous system of the rat. Eur J Neurosci 2000, 12:1194-1216.
11. Lagos P., Torterolo P., Jantos H., Chase M.H., Monti J.M. Effects on sleep of melanin-concentrating hormone microinjection into the dorsal raphe nucleus. Brain Res 2009, 1265:103-110.
12. Lagos P., Urbanavicius J., Scorza M.C., Mirabelles R., Torterolo P. Depressive-like profile induced by MCH microinjections into the dorsal raphe nucleus evaluated in the forced swim test. Behav Brain Res 2011, 218:259-266.
13. Luppi P.H., Gervasoni D., Verret L., Goutagny R., Peyron C., Salvert D., et al. Paradoxical (REM) sleep genesis: the switch from an aminergic-cholinergic to a GABAergic-glutamatergic hypothesis. J Physiol Paris 2006, 100:271-283.
14. Luppi P.H., Clement O., Fort P. Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control. Curr Opin Neurobiol 2013, 23:786-792.
15. McCarley R.W. Neurobiology of REM and NREM sleep. Sleep Med 2007, 8:302-330.
16. Monti J.M., Torterolo P., Lagos P. Melanin-concentrating hormone control of sleep-wake behavior. Sleep Med Rev 2013, 17:293-298.
17. Paxinos G., Watson C. The rat brain 2005, Academic Press, New York.
18. Sapin E., Berod A., Leger L., Herman P.A., Luppi P.H., Peyron C. A very large number of GABAergic neurons are activated in the tuberal hypothalamus during paradoxical (REM) sleep hypersomnia. PLoS ONE 2010, 5:e11766.
19. Szavadi E. Functional neuroanatomy of the central noradrenergic system. J Psychopharmacol 2013, 27:659-693.
20. Torterolo P., Lagos P., Monti J.M. Melanin-concentrating hormone (MCH): a new sleep factor?. Frontier Neurol 2011, 2:1-12.
21. Urbanavicius J., Lagos P., Torterolo P., Scorza C. Prodepressive effect induced by microinjections of MCH into the dorsal raphe: time course, dose dependence, effects on anxiety-related behaviors, and reversion by nortriptyline. Behav Pharmacol 2014, 25:316-324.
22. Yoon Y.S., Lee H.S. Projections from melanin-concentrating hormone (MCH) neurons to the dorsal raphe or the nuclear core of the locus coeruleus in the rat. Brain Res 2013, 1490:72-82.