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Volumn 24, Issue 21, 2014, Pages 5111-5117
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Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of pyrrolopiperidinone acetic acids as CRTh2 antagonists
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Author keywords
CRTh2 antagonist; Permeability; Prodrug; Receptor residence time; Structure activity relationship (SAR); Structure kinetic relationship (SKR)
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Indexed keywords
ACETIC ACID DERIVATIVE;
CHEMOTAXIS INHIBITOR;
CRTH2 ANTAGONIST;
PIPERIDONE DERIVATIVE;
PYRROLINE DERIVATIVE;
UNCLASSIFIED DRUG;
IMMUNOGLOBULIN RECEPTOR;
PIPERIDINE DERIVATIVE;
PROSTAGLANDIN D2 RECEPTOR;
PROSTAGLANDIN RECEPTOR;
PYRAZOLE;
PYRAZOLE DERIVATIVE;
ALKYLATION;
AREA UNDER THE CURVE;
ARTICLE;
BENZYLATION;
BINDING ASSAY;
CATALYSIS;
CHEMICAL PROCEDURES;
CHEMICAL STRUCTURE;
CONJUGATION;
DECARBOXYLATION;
DISSOCIATION;
DRUG BIOAVAILABILITY;
DRUG BLOOD LEVEL;
DRUG HALF LIFE;
DRUG POTENCY;
DRUG SOLUBILITY;
ENANTIOMER;
ESTERIFICATION;
HUMAN;
HYDROGEN BOND;
HYDROLYSIS;
IC50;
LIMIT OF DETECTION;
LIPOPHILICITY;
MAXIMUM PLASMA CONCENTRATION;
MEAN RESIDENCE TIME;
NONHUMAN;
PERMEABILITY;
RAT;
SONOGASHIRA REACTION;
STILLE REACTION;
STRUCTURE ACTIVITY RELATION;
STRUCTURE KINETIC RELATION;
SUZUKI REACTION;
ANIMAL;
ANTAGONISTS AND INHIBITORS;
CACO 2 CELL LINE;
CELL MEMBRANE PERMEABILITY;
CHEMISTRY;
DRUG EFFECTS;
HALF LIFE TIME;
METABOLISM;
ORAL DRUG ADMINISTRATION;
SYNTHESIS;
ACETATES;
ADMINISTRATION, ORAL;
ANIMALS;
CACO-2 CELLS;
CELL MEMBRANE PERMEABILITY;
HALF-LIFE;
HUMANS;
PIPERIDINES;
PYRAZOLES;
RATS;
RECEPTORS, IMMUNOLOGIC;
RECEPTORS, PROSTAGLANDIN;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84908010052
PISSN: 0960894X
EISSN: 14643405
Source Type: Journal
DOI: 10.1016/j.bmcl.2014.08.026 Document Type: Article |
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Times cited : (19)
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References (22)
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