Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Kitaura, Yoshiaki ^a   Hojo, Hironori ^a   Komiyama, Yuske ^a   Takato, Tsuyoshi ^a   Chung, Ung Il ^a,b   Ohba, Shinsuke ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; GLI PROTEIN; ONCOPROTEIN; TRANSACTIVATOR PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MASS; BONE METABOLISM; CALLUS; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FRACTURE NONUNION; GENE ACTIVITY; GENE EXPRESSION; GLI1 GENE; HAPLOINSUFFICIENCY; HOMEOSTASIS; MALE; METABOLIC BONE DISEASE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOCYTE; OSTEOLYSIS; PATHOPHYSIOLOGY; PERINATAL PERIOD; SIGNAL TRANSDUCTION; ANIMAL; BONE DENSITY; BONE DEVELOPMENT; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DEFICIENCY; FEMUR; FRACTURE; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; PATHOLOGY; RADIOGRAPHY; STROMA CELL;

MUS;

ANIMALS; BONE DENSITY; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; FEMUR; FRACTURES, BONE; GENE EXPRESSION REGULATION; GENOTYPE; HAPLOINSUFFICIENCY; HEDGEHOG PROTEINS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ONCOGENE PROTEINS; OSTEOBLASTS; OSTEOGENESIS; SIGNAL TRANSDUCTION; STROMAL CELLS; TRANS-ACTIVATORS;

EID: 84907994038     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109597     Document Type: Article

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