Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors

Oncotarget

Volumn 5, Issue 18, 2014, Pages 8544-8557

  Hassan, Burhan ^a   Akcakanat, Argun ^a   Sangai, Takafumi ^a   Evans, Kurt W ^a   Adkins, Farrell ^a   Eterovic, Agda Karina ^a   Zhao, Hao ^a   Chen, Ken ^a   Chen, Huiqin ^a   Do, Kim Anh ^a   Xie, Shelly M ^a   Holder, Ashley M ^a   Naing, Aung ^a   Mills, Gordon B ^a   Meric Bernstam, Funda ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Akt; Breast cancer; Everolimus; mTOR; Rapamycin

Indexed keywords

3 (2 AMINO 5 BENZOXAZOLYL) 1 ISOPROPYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 AMINE; EVEROLIMUS; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; RAPAMYCIN; ANTINEOPLASTIC AGENT; BENZOXAZOLE DERIVATIVE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MTOR PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; SAPANISERTIB; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG RESISTANCE; DRUG SENSITIVITY; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEOPLASM; NONHUMAN; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; TUMOR XENOGRAFT; ALLOSTERISM; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG DESIGN; DRUG EFFECTS; DRUG SCREENING; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; MUTATION; NUDE MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TIME FACTOR; TUMOR CELL LINE; TUMOR VOLUME;

ALLOSTERIC REGULATION; ANIMALS; ANTINEOPLASTIC AGENTS; BENZOXAZOLES; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; MICE, NUDE; MOLECULAR TARGETED THERAPY; MULTIPROTEIN COMPLEXES; MUTATION; NEOPLASMS; PROTEIN KINASE INHIBITORS; PYRIMIDINES; SIGNAL TRANSDUCTION; SIROLIMUS; TIME FACTORS; TOR SERINE-THREONINE KINASES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84907993261     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2337     Document Type: Article

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