Dohaekseunggi-tang extract inhibits obesity, hyperlipidemia, and hypertension in high-fat diet-induced obese mice

BMC Complementary and Alternative Medicine

Volumn 14, Issue 1, 2014, Pages

  Sung, Yoon Young ^a   Kim, Dong Seon ^a   Choi, Goya ^a   Kim, Seung Hyung ^b   Kim, Ho K ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^b Daejeon University   (South Korea)

Author keywords

Angiotensin 1 converting enzyme; Body weight; Dohaekseunggi tang; High fat diet; Pancreatic lipase; Visceral adipose tissue

Indexed keywords

ADIPONECTIN; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; ANTIOBESITY AGENT; CAPTOPRIL; CHOLESTEROL; DIPEPTIDYL CARBOXYPEPTIDASE; DOHAEKSEUNGGI TANG EXTRACT; GLUCOSE; HERBACEOUS AGENT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ANTIHYPERTENSIVE THERAPY; ARTICLE; BIOCHEMISTRY; BLOOD PRESSURE; BODY WEIGHT; CELL SIZE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL HYPERTENSION; EXPERIMENTAL OBESITY; GLUCOSE BLOOD LEVEL; HYPERLIPIDEMIA; IC50; IN VITRO STUDY; INTRAABDOMINAL FAT; LIPID DIET; LIVER WEIGHT; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; NORMAL VALUE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE CHARACTERIZATION; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; HYPERLIPIDEMIAS; HYPERTENSION; MOUSE MUTANT; OBESITY;

ANIMALS; BLOOD PRESSURE; BODY WEIGHT; DIET, HIGH-FAT; DRUGS, CHINESE HERBAL; HYPERLIPIDEMIAS; HYPERTENSION; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY;

EID: 84907991636     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-372     Document Type: Article

References (34)

1. Son Y, Nam JS, Jang MK, Jung IA, Cho SI, Jung MH. Antiobesity activity of Vigna nakashimae extract in high-fat diet-induced obesity. Biosci Biotechnol Biochem 2013, 77(2):332-338.
2. Medina-Gomez G, Vidal-Puig A. Gateway to the metabolic syndrome. Nat Med 2005, 11(6):602-603. 10.1038/nm0605-602, 15937471.
3. Song MY, Chung SH, Lee JS, Kim SS, Shin HD. The study on pharmacological treatment of obesity in western and oriental medicine. J Oriental Med 1999, 4(1):55-65.
4. Yun JW. Possible anti-obesity therapeutics form nature-A review. Phytochemisty 2010, 71:1625-1641.
5. Kim YS, Lee Y, Kim J, Sohn E, Kim CS, Lee YM, Jo K, Shin S, Song Y, Kim JH, Kim JS. Inhibitory activities of Cudrania tricuspidata leaves on pancreatic lipase in vitro and lipolysis in vivo. Evid Based Complement Alternat Med 2012, 2012:878365. doi: 10.1155/2012/878365, 3529879, 23365603.
6. Filippatos TD, Derdemezis CS, Gazi IF, Nakou ES, Mikhailidis DP, Elisaf MS. Orlistat-associated adverse effects and drug interactions: a critical review. Drug Saf 2008, 31(1):53-65. 10.2165/00002018-200831010-00005, 18095746.
7. Birari RB, Bhutani KK. Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discov Today 2007, 12(19-20):879-889.
8. Kang YY. Treatment of obesity in Chinese medicine. J Peijing Chin Med Coll 1985, 8:26.
9. Wang WJ. Prevention and treatment of metabolic syndrome with integrated traditional Chinese and western medicine. Zhong Xi Yi Jie He Xue Bao 2004, 2(5):390-395. 10.3736/jcim20040524, 15383269.
10. Lai TY, Weng YJ, Kuo WW, Chen LM, Chung YT, Lin YM, Tsai FJ, Lee CH, Choong YM, Lai EY, Huang CY, Yeh YL. Taohe Chengqi Tang ameliorates acute liver injury induced by carbon tetrachloride in rats. Zhong Xi Yi Jie He Xue Bao 2010, 8(1):49-55.
11. Korean Medicine College Circulation of Oriental Medicine·Neurological Medicine 2010, 171-178. Korea: Kunja Press, Korean Medicine College.
12. Chen Q. Pharmacology and Application of Chinese Herbs 1989, 451. Taiwan: SMC.
13. Kim JB, Choi SH, An KS. Study of the effects of Taorenchengqitang and its components on blood stasis model. Korean J Oriental Physiol Pathol 1997, 11:65-76.
14. Yoon JJ, Lee YJ, Park OJ, Lee SM, Lee YP, Cho NG, Kang DG, Lee HS. Doinseunggitang ameliorates endothelial dysfunction in diabetic atherosclerosis. Evid Based Complement Alternat Med 2013, 2013:783576. doi:10.1155/2013/783576, 3766992, 24062791.
15. Jeong JH. The effects of Dohaeksungitang on the weight and lipid metabolism of induced obesity rats. MA thesis Hyung Hee University, Department of Oriental Medicine;1993.
16. Lee YJ, Kin EK, Kim HY, Yoon JJ, Lee SM, Lee GM, Kang DG, Lee HS. Therapeutic effect of Doinseunggi-tang on diabetic vascular dysfunction. Herb Formul Sci 2013, 21(1):119-130.
17. Furukawa I, Kurooka S, Arisue K, Kohda K, Hayashi C. Assays of serum lipase by the " BALB-DTNB method" mechanized for use with discrete and continuous-flow analyzers. Clin Chem 1982, 28(1):110-113.
18. Harp JB. New insights into inhibitors of adipogenesis. Curr Opin Lipidol 2004, 15(3):303-307. 10.1097/00041433-200406000-00010, 15166786.
19. Fasshauer M, Paschke R. Regulation of adipocytokines and insulin resistance. Diabetologia 2003, 46(12):1594-1603. 10.1007/s00125-003-1228-z, 14605806.
20. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999, 257(1):79-83. 10.1006/bbrc.1999.0255, 10092513.
21. Maffei M, Halaas J, Ravussin E, Pratley RE, LeeGH ZY, Fei H, Kim S, Lallone R, Ranganathan S, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995, 1(11):1155-1161. 10.1038/nm1195-1155, 7584987.
22. Shin SS, Jung YS, Yoon KH, Choi S, Hong Y, Park D, Lee H, Seo BI, Lee HY, Yoon M. The Korean traditional medicine gyeongshingangjeehwan inhibits adipocyte hypertrophy and visceral adipose tissue accumulation by activating PPARalpha actions in rat white adipose tissues. J Ethnopharmacol 2010, 127(1):47-54. 10.1016/j.jep.2009.09.052, 19799979.
23. Schoonjans K, Staels B, Auwerx J. The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1996, 1302(2):93-109. 10.1016/0005-2760(96)00066-5, 8695669.
24. Vidal-Puig A1, Jimenez-Liñan M, Lowell BB, Hamann A, Hu E, Spiegelman B, Flier JS, Moller D. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest 1996, 97(11):2553-2561. 10.1172/JCI118703, 507341, 8647948.
25. Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: more than just another fat cell hormone?. Diabetes Care 2003, 26(8):2442-2450. 10.2337/diacare.26.8.2442, 12882876.
26. Yu JG, Javorschi S, Hevener AL, Kruszynska YT, Norman RA, Sinha M, Olefsky JM. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes 2002, 51(10):2968-2974. 10.2337/diabetes.51.10.2968, 12351435.
27. Kersten S. Peroxisome proliferator activated receptors and obesity. Eur J Pharmacol 2002, 440(2-3):223-234.
28. Andrews ZB, Erion DM, Beiler R, Choi CS, Shulman GI, Horvath TL. Uncoupling protein-2 decreases the lipogenic actions of ghrelin. Endocrinology 2010, 151(5):2078-2086. 10.1210/en.2009-0850, 2869261, 20189996.
29. Lowe ME. Pancreatic triglyceride lipase and colipase: insights into dietary fat digestion. Gastroenterology 1994, 107(5):1524-1536. 10.1016/0016-5085(94)90559-2, 7926517.
30. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, Marks JS. Prevalence of obesity, diabetes, and obesity-related health risk factors. JAMA 2003, 289(1):76-79.
31. Rüster C, Wolf G. The role of the renin-angiotensin-aldosterone system in obesity-related renal diseases. Semin Nephrol 2013, 33(1):44-53. 10.1016/j.semnephrol.2012.12.002, 23374893.
32. Xie Y, Zhang W. Antihypertensive activity of Rosa rugosa Thunb. flowers: angiotensin I converting enzyme inhibitor. J Ethnopharmacol 2012, 144(3):562-566. 10.1016/j.jep.2012.09.038, 23063753.
33. Thethi T, Kamiyama M, Kobori H. The link between the renin-angiotensin-aldosterone system and renal injury in obesity and the metabolic syndrome. Curr Hypertens Rep 2012, 14(2):160-169. 10.1007/s11906-012-0245-z, 3337881, 22302531.
34. Frigolet ME, Torres N, Tovar AR. The renin-angiotensin system in adipose tissue and its metabolic consequences during obesity. J Nutr Biochem 2013, 24(12):2003-2015. 10.1016/j.jnutbio.2013.07.002, 24120291.