Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages

Cancer Cell

Volumn 26, Issue 4, 2014, Pages 534-548

  Hsu, DennisShin Shian ^a   Wang, Hsiao Jung ^a   Tai, Shyh Kuan ^b   Chou, Chun Hung ^a   Hsieh, Chia Hsin ^a   Chiu, Po Hsien ^a   Chen, Nien Jung ^a   Yang, Muh Hwa ^a,b,c  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c GENOMICS RESEARCH CENTER   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYTOKINE; I KAPPA B KINASE ALPHA; LYSINE; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TRANSCRIPTION FACTOR SNAIL; TUMOR NECROSIS FACTOR ALPHA; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER PROGNOSIS; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; DEACETYLATION; DNA BINDING; EPITHELIAL MESENCHYMAL TRANSITION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE MIGRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ACETYLATION; PROTEIN EXPRESSION; REPRESSOR GENE; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; ACETYLATION; ANIMAL; MACROPHAGE; METABOLISM; MOLECULAR GENETICS; NEOPLASM; PATHOLOGY; PROGNOSIS; SCID MOUSE;

GASTROPODA;

ACETYLATION; ANIMALS; MACROPHAGES; MICE; MICE, SCID; MOLECULAR SEQUENCE DATA; NEOPLASMS; PROGNOSIS; TRANSCRIPTION FACTORS;

EID: 84907990586     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2014.09.002     Document Type: Article

References (47)

1. Ansieau S., Bastid J., Doreau A., Morel A.P., Bouchet B.P., Thomas C., Fauvet F., Puisieux I., Doglioni C., Piccinin S., et al. Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 2008, 14:79-89.
2. Azenshtein E., Luboshits G., Shina S., Neumark E., Shahbazian D., Weil M., Wigler N., Keydar I., Ben-Baruch A. The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity. Cancer Res. 2002, 62:1093-1102.
3. Berger S.L. The complex language of chromatin regulation during transcription. Nature 2007, 447:407-412.
4. Biswas S.K., Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat. Immunol. 2010, 11:889-896.
5. Brooks C.L., Gu W. The impact of acetylation and deacetylation on the p53 pathway. Protein Cell 2011, 2:456-462.
6. Cano A., Pérez-Moreno M.A., Rodrigo I., Locascio A., Blanco M.J., del Barrio M.G., Portillo F., Nieto M.A. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2000, 2:76-83.
7. Chio I.I., Sasaki M., Ghazarian D., Moreno J., Done S., Ueda T., Inoue S., Chang Y.L., Chen N.J., Mak T.W. TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. Nat. Cell Biol. 2012, 14:625-633.
8. Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009, 325:834-840.
9. De Craene B., Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat. Rev. Cancer 2013, 13:97-110.
10. Eckert M.A., Lwin T.M., Chang A.T., Kim J., Danis E., Ohno-Machado L., Yang J. Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell 2011, 19:372-386.
11. Goldfeld A.E., Doyle C., Maniatis T. Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 1990, 87:9769-9773.
12. Gu W., Roeder R.G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 1997, 90:595-606.
13. Guo Y., Xu F., Lu T., Duan Z., Zhang Z. Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat. Rev. 2012, 38:904-910.
14. Guttridge D.C., Albanese C., Reuther J.Y., Pestell R.G., Baldwin A.S. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 1999, 19:5785-5799.
15. Herranz N., Pasini D., Díaz V.M., Francí C., Gutierrez A., Dave N., Escrivà M., Hernandez-Muñoz I., Di Croce L., Helin K., et al. Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol. Cell. Biol. 2008, 28:4772-4781.
16. Hou Z., Peng H., Ayyanathan K., Yan K.P., Langer E.M., Longmore G.D., Rauscher F.J. The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol. Cell. Biol. 2008, 28:3198-3207.
17. Hsu D.S., Lan H.Y., Huang C.H., Tai S.K., Chang S.Y., Tsai T.L., Chang C.C., Tzeng C.H., Wu K.J., Kao J.Y., Yang M.H. Regulation of excision repair cross-complementation group 1 by Snail contributes to cisplatin resistance in head and neck cancer. Clin. Cancer Res. 2010, 16:4561-4571.
18. Hu C.T., Chang T.Y., Cheng C.C., Liu C.S., Wu J.R., Li M.C., Wu W.S. Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. FEBS J. 2010, 277:1202-1218.
19. Huang W.C., Ju T.K., Hung M.C., Chen C.C. Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Mol. Cell 2007, 26:75-87.
20. Hwang W.L., Yang M.H., Tsai M.L., Lan H.Y., Su S.H., Chang S.C., Teng H.W., Yang S.H., Lan Y.T., Chiou S.H., et al. The Snail-IL8 axis engenders stemness and tumorigenic characteristics in human colorectal carcinoma. Gastroenterology 2011, 141:279-291.
21. Hwang W.L., Jiang J.K., Yang S.H., Huang T.S., Lan H.Y., Teng H.W., Yang C.Y., Tsai Y.P., Lin C.H., Wang H.W., Yang M.H. MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells. Nat. Cell Biol. 2014, 16:268-280.
22. Ito A., Lai C.H., Zhao X., Saito S., Hamilton M.H., Appella E., Yao T.P. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J. 2001, 20:1331-1340.
23. Javaid S., Zhang J., Anderssen E., Black J.C., Wittner B.S., Tajima K., Ting D.T., Smolen G.A., Zubrowski M., Desai R., et al. Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1. Cell Reports 2013, 5:1679-1689.
24. Li C.W., Xia W., Huo L., Lim S.O., Wu Y., Hsu J.L., Chao C.H., Yamaguchi H., Yang N.K., Ding Q., et al. Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1. Cancer Res. 2012, 72:1290-1300.
25. Loetscher P., Seitz M., Clark-Lewis I., Baggiolini M., Moser B. Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2. FEBS Lett. 1994, 341:187-192.
26. Lyons J.G., Patel V., Roue N.C., Fok S.Y., Soon L.L., Halliday G.M., Gutkind J.S. Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes. Cancer Res. 2008, 68:4525-4530.
27. Mani S.A., Guo W., Liao M.J., Eaton E.N., Ayyanan A., Zhou A.Y., Brooks M., Reinhard F., Zhang C.C., Shipitsin M., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715.
28. Mantovani A., Sozzani S., Locati M., Allavena P., Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002, 23:549-555.
29. McKenna N.J., O'Malley B.W. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 2002, 108:465-474.
30. McKinsey T.A., Zhang C.L., Olson E.N. MEF2: a calcium-dependent regulator of cell division, differentiation and death. Trends Biochem. Sci. 2002, 27:40-47.
31. Pasparakis M., Alexopoulou L., Episkopou V., Kollias G. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J.Exp. Med. 1996, 184:1397-1411.
32. Peinado H., Ballestar E., Esteller M., Cano A. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol. Cell. Biol. 2004, 24:306-319.
33. Qian B.Z., Li J., Zhang H., Kitamura T., Zhang J., Campion L.R., Kaiser E.A., Snyder L.A., Pollard J.W. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 2011, 475:222-225.
34. Rembold M., Ciglar L., Yáñez-Cuna J.O., Zinzen R.P., Girardot C., Jain A., Welte M.A., Stark A., Leptin M., Furlong E.E. A conserved role for Snail as a potentiator of active transcription. Genes Dev. 2014, 28:167-181.
35. Rhodes D.R., Yu J., Shanker K., Deshpande N., Varambally R., Ghosh D., Barrette T., Pandey A., Chinnaiyan A.M. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 2004, 6:1-6.
36. Stanisavljevic J., Porta-de-la-Riva M., Batlle R., de Herreros A.G., Baulida J. The p65 subunit of NF-κB and PARP1 assist Snail1 in activating fibronectin transcription. J.Cell Sci. 2011, 124:4161-4171.
37. Stein M., Keshav S., Harris N., Gordon S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J.Exp. Med. 1992, 176:287-292.
38. Ueda A., Ishigatsubo Y., Okubo T., Yoshimura T. Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-kappaB sites and NF-kappaB/Rel subunit specificity. J.Biol. Chem. 1997, 272:31092-31099.
39. Vega S., Morales A.V., Ocaña O.H., Valdés F., Fabregat I., Nieto M.A. Snail blocks the cell cycle and confers resistance to cell death. Genes Dev. 2004, 18:1131-1143.
40. Wickremasinghe M.I., Thomas L.H., O'Kane C.M., Uddin J., Friedland J.S. Transcriptional mechanisms regulating alveolar epithelial cell-specific CCL5 secretion in pulmonary tuberculosis. J.Biol. Chem. 2004, 279:27199-27210.
41. Wu Y., Zhou B.P. TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion. Br. J. Cancer 2010, 102:639-644.
42. Wu Y., Deng J., Rychahou P.G., Qiu S., Evers B.M., Zhou B.P. Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell 2009, 15:416-428.
43. Wu M.Z., Tsai Y.P., Yang M.H., Huang C.H., Chang S.Y., Chang C.C., Teng S.C., Wu K.J. Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition. Mol. Cell 2011, 43:811-822.
44. Wu C., Fernandez S.A., Criswell T., Chidiac T.A., Guttridge D., Villalona-Calero M., Bekaii-Saab T.S. Disrupting cytokine signaling in pancreatic cancer: a phase I/II study of etanercept in combination with gemcitabine in patients with advanced disease. Pancreas 2013, 42:813-818.
45. Yang W.H., Lan H.Y., Huang C.H., Tai S.K., Tzeng C.H., Kao S.Y., Wu K.J., Hung M.C., Yang M.H. RAC1 activation mediates Twist1-induced cancer cell migration. Nat. Cell Biol. 2012, 14:366-374.
46. Zhou B.P., Deng J., Xia W., Xu J., Li Y.M., Gunduz M., Hung M.C. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 2004, 6:931-940.
47. Zidi I., Mestiri S., Bartegi A., Amor N.B. TNF-alpha and its inhibitors in cancer. Med. Oncol. 2010, 27:185-198.