SLC30A10 is a cell surface-localized manganese efflux transporter, And parkinsonism-causing mutations block its intracellular trafficking and efflux activity

Journal of Neuroscience

Volumn 34, Issue 42, 2014, Pages 14079-14095

  Leyva Illades, Dinorah ^a   Chen, Pan ^b   Zogzas, Charles E ^a   Hutchens, Steven ^a   Mercado, Jonathan M ^a   Swaim, Caleb D ^a   Morrisett, Richard A ^a   Bowman, Aaron B ^c   Aschner, Michael ^b   Mukhopadhyay, Somshuvra ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Efflux; GPP130; Manganese; Parkinsonism; SLC30A10; Trafficking

Indexed keywords

GREEN FLUORESCENT PROTEIN; MANGANESE; PROTEIN; SLC30A10 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CATION TRANSPORT PROTEIN; SLC30A8 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; CAENORHABDITIS ELEGANS; CELL MIGRATION; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE MICROSCOPY; ION TRANSPORT; MASS SPECTROMETRY; MOUSE; MTT ASSAY; NERVE DEGENERATION; NEUROTRANSMISSION; NONHUMAN; PARKINSONISM; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURFACE BIOTINYLATION ASSAY; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL MEMBRANE; FEMALE; GENETICS; HELA CELL LINE; INTRACELLULAR FLUID; MALE; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN TRANSPORT;

ANIMALS; CAENORHABDITIS ELEGANS; CATION TRANSPORT PROTEINS; CELL MEMBRANE; CELLS, CULTURED; FEMALE; HELA CELLS; HUMANS; INTRACELLULAR FLUID; MALE; MANGANESE; MICE, INBRED C57BL; MUTATION; PARKINSONIAN DISORDERS; PROTEIN TRANSPORT;

EID: 84907967528     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2329-14.2014     Document Type: Article

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