Identification of the Zn2+ binding site and mode of operation of a mammalian Zn2+ transporter

Journal of Biological Chemistry

Volumn 284, Issue 26, 2009, Pages 17677-17686

  Ohana, Ehud ^a   Hoch, Eitan ^a   Keasar, Chen ^a   Kambe, Taiho ^b   Yifrach, Ofer ^a   Hershfinkel, Michal ^a   Sekler, Israel ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; CELLULAR COMPARTMENTS; FUNCTIONAL ASPECTS; INTRACELLULAR LOCALIZATION; ION BINDING SITES; METAL TRANSPORTERS; MODE OF OPERATIONS; STRUCTURAL MODELING; TRANS-GOLGI NETWORK; X-RAY STRUCTURE; ZINC TRANSPORT; ZINC TRANSPORTERS; ZINC-BINDING SITES;

BINDING ENERGY; CYTOLOGY; MAMMALS; MEDICAL PROBLEMS; METAL RECOVERY; STRUCTURAL METALS; ZINC; ZINC METALLOGRAPHY;

BINDING SITES;

ALANINE; ASPARTIC ACID; HISTIDINE; ZINC TRANSPORTER; CATION TRANSPORT PROTEIN; PROTON; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SLC30A5 PROTEIN, HUMAN; SLC39A6 PROTEIN, HUMAN; TUMOR PROTEIN; ZINC;

ALKALINIZATION; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; TRANS GOLGI NETWORK; ZINC METABOLISM; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; GENETICS; KIDNEY; METABOLISM; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS;

BACTERIA (MICROORGANISMS); MAMMALIA;

ASPARTIC ACID; BINDING SITES; CATION TRANSPORT PROTEINS; CELLS, CULTURED; CYTOPLASM; HISTIDINE; HUMANS; KIDNEY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NEOPLASM PROTEINS; PROTEIN CONFORMATION; PROTONS; TRANS-GOLGI NETWORK; VACUOLAR PROTON-TRANSLOCATING ATPASES; ZINC;

EID: 67650540770     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.007203     Document Type: Article

References (47)

1. Vallee, B. L., and Falchuk, K. H. (1993) Physiol. Rev. 73, 79-118
2. Sekler, I., Sensi, S. L., Hershfinkel, M., and Silverman, W. F. (2007) Mol. Med. 13, 337-343
3. Seve, M., Chimienti, F., Devergnas, S., and Favier, A. (2004) BMC Genomics 5, 32
4. Lee, J. Y., Cole, T. B., Palmiter, R. D., Suh, S. W., and Koh, J. Y. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 7705-7710
5. Huang, L., and Gitschier, J. (1997) Nat. Genet. 17, 292-297
6. Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., Balkau, B., Heude, B., Charpentier, G., Hudson, T. J., Montpetit, A., Pshezhetsky, A. V., Prentki, M., Posner, B. I., Balding, D. J., Meyre, D., Polychronakos, C., and Froguel, P. (2007) Nature 445, 881-885
7. Ishihara, K., Yamazaki, T., Ishida, Y., Suzuki, T., Oda, K., Nagao, M., Yamaguchi-Iwai, Y., and Kambe, T. (2006) J. Biol. Chem. 281, 17743-17750
8. Jackson, K. A., Helston, R. M., McKay, J. A., O'Neill, E. D., Mathers, J. C., and Ford, D. (2007) J. Biol. Chem. 282, 10423-10431
9. Inoue, K., Matsuda, K., Itoh, M., Kawaguchi, H., Tomoike, H., Aoyagi, T., Nagai, R., Hori, M., Nakamura, Y., and Tanaka, T. (2002) Hum. Mol. Genet. 11, 1775-1784
10. Valentine, R. A., Jackson, K. A., Christie, G. R., Mathers, J. C., Taylor, P. M., and Ford, D. (2007) J. Biol. Chem. 282, 14389-14393
11. Suzuki, T., Ishihara, K., Migaki, H., Matsuura, W., Kohda, A., Okumura, K., Nagao, M., Yamaguchi-Iwai, Y., and Kambe, T. (2005) J. Biol. Chem. 280, 637-643
12. Ellis, C. D., Macdiarmid, C. W., and Eide, D. J. (2005) J. Biol. Chem. 280, 28811-28818
13. Chao, Y., and Fu, D. (2004) J. Biol. Chem. 279, 12043-12050
14. Lu, M., and Fu, D. (2007) Science 317, 1746-1748
15. MacDiarmid, C. W., Milanick, M. A., and Eide, D. J. (2002) J. Biol. Chem. 277, 39187-39194
16. Kawachi, M., Kobae, Y., Mimura, T., and Maeshima, M. (2008) J. Biol. Chem. 283, 8374-8383
17. Ohana, E., Segal, D., Palty, R., Ton-That, D., Moran, A., Sensi, S. L., Weiss, J. H., Hershfinkel, M., and Sekler, I. (2004) J. Biol. Chem. 279, 4278-4284
18. Kambe, T., Narita, H., Yamaguchi-Iwai, Y., Hirose, J., Amano, T., Sugiura, N., Sasaki, R., Mori, K., Iwanaga, T., and Nagao, M. (2002) J. Biol. Chem. 277, 19049-19055
19. Suzuki, T., Ishihara, K., Migaki, H., Ishihara, K., Nagao, M., Yamaguchi-Iwai, Y., and Kambe, T. (2005) J. Biol. Chem. 280, 30956-30962
20. Nitzan, Y. B., Sekler, I., Hershfinkel, M., Moran, A., and Silverman, W. F. (2002) Brain Res. Dev. Brain Res. 137, 149-157
21. Hershfinkel, M., Moran, A., Grossman, N., and Sekler, I. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 11749-11754
22. Burdette, S. C., Walkup, G. K., Spingler, B., Tsien, R. Y., and Lippard, S. J. (2001) J. Am. Chem. Soc. 123, 7831-7841
23. Machen, T. E., Leigh, M. J., Taylor, C., Kimura, T., Asano, S., and Moore, H. P. (2003) Am. J. Physiol. Cell Physiol. 285, C205-214
24. Miesenböck, G., De Angelis, D. A., and Rothman, J. E. (1998) Nature 394, 192-195
25. Azriel-Tamir, H., Sharir, H., Schwartz, B., and Hershfinkel, M. (2004) J. Biol. Chem. 279, 51804-51816
26. Markwell, M. A., Haas, S. M., Bieber, L. L., and Tolbert, N. E. (1978) Anal. Biochem. 87, 206-210
27. Sekler, I., Moran, A., Hershfinkel, M., Dori, A., Margulis, A., Birenzweig, N., Nitzan, Y., and Silverman, W. F. (2002) J. Comp. Neurol. 447, 201-209
28. Ginalski, K., Elofsson, A., Fischer, D., and Rychlewski, L. (2003) Bioinformatics 19, 1015-1018
29. Kalisman, N., Levi, A., Maximova, T., Reshef, D., Zafriri-Lynn, S., Gleyzer, Y., and Keasar, C. (2005) Bioinformatics 21, 3931-3932
30. Huang, L., Kirschke, C. P., and Gitschier, J. (2002) J. Biol. Chem. 277, 26389-26395
31. Sekler, I., Lo, R. S., and Kopito, R. R. (1995) J. Biol. Chem. 270, 28751-28758
32. Atar, D., Backx, P. H., Appel, M. M., Gao, W. D., and Marban, E. (1995) J. Biol. Chem. 270, 2473-2477
33. Canzoniero, L. M., Sensi, S. L., and Choi, D. W. (1997) Neurobiol. Dis. 4, 275-279
34. Schapiro, F. B., and Grinstein, S. (2000) J. Biol. Chem. 275, 21025-21032
35. Love, R., Salazar, G., and Faundez, V. (2005) Brain. Res. 1061, 1-12
36. Ramsey, I. S., Moran, M. M., Chong, J. A., and Clapham, D. E. (2006) Nature 440, 1213-1216
37. Stiernet, P., Guiot, Y., Gilon, P., and Henquin, J. C. (2006) J. Biol. Chem. 281, 22142-22151
38. Dunn, M. F. (2005) Biometals 18, 295-303
39. Sensi, S. L., Rockabrand, E., and Canzoniero, L. M. (2006) Biogerontology 7, 367-374
40. Jordan, B. A., Trapaidze, N., Gomes, I., Nivarthi, R., and Devi, L. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 343-348
41. Levi, V., Rossi, J. P., Castello, P. R., and González Flecha, F. L. (2002) Biophys. J. 82, 437-446
42. Wei, Y., and Fu, D. (2006) J. Biol. Chem. 281, 23492-23502
43. Mao, X., Kim, B. E., Wang, F., Eide, D. J., and Petris, M. J. (2007) J. Biol. Chem. 282, 6992-7000
44. Montanini, B., Blaudez, D., Jeandroz, S., Sanders, D., and Chalot, M. (2007) BMC Genomics 8, 107
45. Chao, Y., and Fu, D. (2004) J. Biol. Chem. 279, 17173-17180
46. Wei, Y., and Fu, D. (2005) J. Biol. Chem. 280, 33716-33724
47. Obara, K., Miyashita, N., Xu, C., Toyoshima, I., Sugita, Y., Inesi, G., and Toyoshima, C. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 14489-14496