Hiding from intracellular pattern recognition receptors, a passive strategy of flavivirus immune evasion

Virulence

Volumn 2, Issue 3, 2011, Pages 238-240

  Överby, Anna K ^a   Weber, Friedemann ^b  

^a UMEÅ UNIVERSITY   (Sweden)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Double stranded RNA; Interferon induction; IRF3; Replication vesicles; Tick borne encephalitis virus (TBEV)

Indexed keywords

CYTOKINE; DOUBLE STRANDED RNA; INTERFERON; PATTERN RECOGNITION RECEPTOR; VIRUS RNA;

ARTICLE; ASIA; CYTOPLASM; EUROPE; FLAVIVIRUS; IMMUNE RESPONSE; INTERFERON PRODUCTION; MEMBRANE VESICLE; NONHUMAN; PROGENY; TICK BORNE ENCEPHALITIS FLAVIVIRUS; VIRUS ENCEPHALITIS; VIRUS MENINGITIS;

FLAVIVIRUS; TICK-BORNE ENCEPHALITIS VIRUS;

EID: 85011940678     PISSN: 21505594     EISSN: 21505608     Source Type: Journal    
DOI: 10.4161/viru.2.3.16162     Document Type: Article

References (22)

1. Charrel RN, Attoui H, Butenko AM, Clegg JC, Deubel V, Frolova TV, et al. Tick-borne virus diseases of human interest in Europe. Clin Microbiol Infect 2004; 10:1040-1055.
2. Lindquist L, Vapalahti O. Tick-borne encephalitis. Lancet 2008; 71:1861-1871.
3. Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 2009; 22:240-273.
4. Hiscott J. Triggering the innate/antiviral response through Irf-3 activation. J Biol Chem 2007; 282:15325-15329.
5. Pichlmair A, Reis e Sousa C. Innate recognition of viruses. Immunity 2007; 27:370-83.
6. Randall RE, Goodbourn S. Interferons and viruses: An interplay between induction, signaling, antiviral responses and virus countermeasures. J Gen Virol 2008; 89:1-47
7. Sadler AJ, Williams BR. Interferon-inducible antiviral effectors. Nat Rev Immunol 2008; 8:559-568.
8. Weber F, Wagner V, Rasmussen SB, Hartmann R, Paludan SR. Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. J Virol 2006; 80:5059-5064.
9. Diamond MS. Mechanisms of evasion of the type I interferon antiviral response by flaviviruses. J Interferon Cytokine Res 2009; 29:521-530.
10. Keller BC, Johnson CL, Erickson AK, Gale M Jr. Innate immune evasion by hepatitis C virus and West Nile virus. Cytokine Growth Factor Rev 2007; 18:535-544.
11. Munoz-Jordan JL, Laurent-Rolle M, Ashour J, Martinez-Sobrido L, Ashok M, Lipkin WI, et al. Inhibition of alpha/beta interferon signaling by the ns4b protein of flaviviruses. J Virol 2005; 79:8004-8013.
12. Robertson SJ, Mitzel DN, Taylor RT, Best SM, Bloom ME. Tick-borne flaviviruses: Dissecting host immune responses and virus countermeasures. Immunol Res 2009; 43:172-86.
13. Werme K, Wigerius M, Johansson M. Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated jak-stat signaling. Cell Microbiol 2008; 10:696-712.
14. Overby AK, Popov VL, Niedrig M, Weber F. Tick-borne encephalitis virus delays interferon induction and hides its double-stranded RNA in intracellular membrane vesicles. J Virol 2010; 84:8470-883.
15. Gillespie LK, Hoenen A, Morgan G, Mackenzie JM. The endoplasmic reticulum provides the membrane platform for biogenesis of the flavivirus replication complex. J Virol 2010; 84:10438-10447.
16. Welsch S, Miller S, Romero-Brey I, Merz A, Bleck CK, Walther P, et al. Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe 2009; 5:365-375.
17. Lu C, Ranjith-Kumar CT, Hao L, Kao CC, Li P. Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5 triphosphate. Nucleic Acids Res 2011; 39:1565-1575.
18. Lu C, Xu H, Ranjith-Kumar CT, Brooks MT, Hou TY, Hu F, et al. The structural basis of 5' triphosphate double-stranded RNA recognition by RIG-I C-terminal domain. Structure 2010; 18:1032-1043.
19. Wang Y, Ludwig J, Schuberth C, Goldeck M, Schlee M, Li H, et al. Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor rig-i. Nat Struct Mol Biol 2010; 17:781-787
20. Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, et al. Ips-1, an adaptor triggering RIG-I- and MDA5-mediated type I interferon induction. Nat Immunol 2005; 6:981-988.
21. Ahlquist P. Parallels among positive-strand RNA viruses, reverse-transcribing viruses and double-stranded RNA viruses. Nat Rev Microbiol 2006; 4:371-382.
22. Mackenzie J. Wrapping things up about virus RNA replication. Traffic 2005; 6:967-977