Conversion of human fibroblasts into monocyte-like progenitor cells

Stem Cells

Volumn 32, Issue 11, 2014, Pages 2923-2938

  Pulecio, Julian ^a   Nivet, Emmanuel ^b   Sancho Martinez, Ignacio ^b   Vitaloni, Marianna ^a   Guenechea, Guillermo ^c   Xia, Yun ^b   Kurian, Leo ^b   Dubova, Ilir ^b   Bueren, Juan ^c   Laricchia Robbio, Leopoldo ^a   Belmonte, Juan Carlos Izpisua ^b  

^a CENTER OF REGENERATIVE MEDICINE IN BARCELONA   (Spain)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

Author keywords

Blood; Macrophages; miRNAs; Monocytes; Reprogramming; Transdifferentiation

Indexed keywords

ANTIGENS, CD34; ANTIGENS, CD45;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; CYTOLOGY; FIBROBLASTS; HUMANS; METABOLISM; MICE; MONOCYTES; PHYSIOLOGY; STEM CELLS;

ANIMALS; ANTIGENS, CD34; ANTIGENS, CD45; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; FIBROBLASTS; HUMANS; MICE; MONOCYTES; STEM CELLS;

EID: 84907907255     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1800     Document Type: Article

References (47)

1. Takahashi K, Yamanaka S,. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676.
2. Panopoulos AD, Ruiz S, Izpisua Belmonte JC,. iPSCs: Induced back to controversy. Cell Stem Cell 2011; 8: 347-348.
3. Sancho-Martinez I, Baek SH, Izpisua Belmonte JC,. Lineage conversion methodologies meet the reprogramming toolbox. Nat Cell Biol 2012; 14: 892-899.
4. Anokye-Danso F, Trivedi CM, Juhr D, et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 2011; 8: 376-388.
5. Vierbuchen T, Wernig M. Direct lineage conversions: Unnatural but useful? Nat Biotechnol 2011; 29: 892-907.
6. Vierbuchen T, Ostermeier A, Pang ZP, et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010; 463: 1035-1041.
7. Ieda M, Fu JD, Delgado-Olguin P, et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010; 142: 375-386.
8. Sekiya S, Suzuki A,. Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 2011; 475: 390-393.
9. Kurian L, Sancho-Martinez I, Nivet E, et al. Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods 2013; 10: 77-83.
10. Efe JA, Hilcove S, Kim J, et al. Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol 2011; 13: 215-222.
11. Ladewig J, Koch P, Brustle O,. Leveling Waddington: The emergence of direct programming and the loss of cell fate hierarchies. Nat Rev Mol Cell Biol 2013; 14: 225-236.
12. Robinton DA, Daley GQ,. The promise of induced pluripotent stem cells in research and therapy. Nature 2012; 481: 295-305.
13. Szabo E, Rampalli S, Risueno RM, et al. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 2010; 468: 521-526.
14. Pereira CF, Chang B, Qiu J, et al. Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell 2013; 13: 205-218.
15. Arnold K, Sarkar A, Yram MA, et al. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell 2011; 9: 317-329.
16. Polo JM, Anderssen E, Walsh RM, et al. A molecular roadmap of reprogramming somatic cells into iPS cells. Cell 2012; 151: 1617-1632.
17. Ebert MS, Sharp PA,. Roles for microRNAs in conferring robustness to biological processes. Cell 2012; 149: 515-524.
18. Subramanyam D, Lamouille S, Judson RL, et al. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol 2011; 29: 443-448.
19. Yoo AS, Sun AX, Li L, et al. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 2011; 476: 228-231.
20. Williams AH, Valdez G, Moresi V, et al. MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science 2009; 326: 1549-1554.
21. Eulalio A, Mano M, Dal Ferro M, et al. Functional screening identifies miRNAs inducing cardiac regeneration. Nature 2012; 492: 376-381.
22. Georgantas RW, 3rd, Hildreth R, Morisot S, et al. CD34+ hematopoietic stem-progenitor cell microRNA expression and function: A circuit diagram of differentiation control. Proc Natl Acad Sci USA 2007; 104: 2750-2755.
23. Liao R, Sun J, Zhang L, et al. MicroRNAs play a role in the development of human hematopoietic stem cells. J Cell Biochem 2008; 104: 805-817.
24. Merkerova M, Vasikova A, Belickova M, et al. MicroRNA expression profiles in umbilical cord blood cell lineages. Stem Cells Dev 2010; 19: 17-26.
25. O'Connell RM, Chaudhuri AA, Rao DS, et al. MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proc Natl Acad Sci USA 2010; 107: 14235-14240.
26. Chaudhuri AA, So AY, Mehta A, et al. Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A. Proc Natl Acad Sci USA 2012; 109: 4233-4238.
27. Ooi AG, Sahoo D, Adorno M, et al. MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets. Proc Natl Acad Sci USA 2010; 107: 21505-21510.
28. Bresnick EH, Katsumura KR, Lee HY, et al. Master regulatory GATA transcription factors: Mechanistic principles and emerging links to hematologic malignancies. Nucleic Acids Res 2012; 40: 5819-5831.
29. Ichikawa M, Asai T, Chiba S, et al. Runx1/AML-1 ranks as a master regulator of adult hematopoiesis. Cell Cycle 2004; 3: 722-724.
30. Notta F, Doulatov S, Laurenti E, et al. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 2011; 333: 218-221.
31. Xie H, Ye M, Feng R, et al. Stepwise reprogramming of B cells into macrophages. Cell 2004; 117: 663-676.
32. Laiosa CV, Stadtfeld M, Xie H, et al. Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity 2006; 25: 731-744.
33. Feng R, Desbordes SC, Xie H, et al. PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells. Proc Natl Acad Sci USA 2008; 105: 6057-6062.
34. O'Connell RM, Zhao JL, Rao DS,. MicroRNA function in myeloid biology. Blood 2011; 118: 2960-2969.
35. El Gazzar M, McCall CE,. MicroRNAs regulatory networks in myeloid lineage development and differentiation: Regulators of the regulators. Immunol Cell Biol 2012; 90: 587-593.
36. Rapino F, Robles EF, Richter-Larrea JA, et al. C/EBPalpha induces highly efficient macrophage transdifferentiation of B lymphoma and leukemia cell lines and impairs their tumorigenicity. Cell Rep 2013; 3: 1153-1163.
37. Soufi A, Donahue G, Zaret KS,. Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome. Cell 2012; 151: 994-1004.
38. Zaret KS, Carroll JS,. Pioneer transcription factors: Establishing competence for gene expression. Genes Dev 2011; 25: 2227-2241.
39. Kumar M, Lu Z, Takwi AA, et al. Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene 2011; 30: 843-853.
40. Le MT, Teh, C, Shyh-Chang, N, et al. MicroRNA-125b is a novel negative regulator of p53. Genes Dev 2009; 23: 862-876.
41. Sun YM, Lin KY, Chen YQ,. Diverse functions of miR-125 family in different cell contexts. J Hematol Oncol 2013; 6: 6.
42. Ring KL, Tong LM, Balestra ME, et al. Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell 2012; 11: 100-109.
43. Thier M, Worsdorfer P, Lakes YB, et al. Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell 2012; 10: 473-479.
44. Loh KM, Lim B,. A precarious balance: Pluripotency factors as lineage specifiers. Cell Stem Cell 2011; 8: 363-369.
45. Mitchell RR, Szabo E, Benoit YD, et al. Activation of neural cell fate programs toward direct conversion of adult human fibroblasts into tri-potent neural progenitors using OCT-4. Stem Cells Dev 2014, ahead of print. doi:10.1089/scd.2014.0023.
46. Montserrat N, Nivet E, Sancho-Martinez I, et al. Reprogramming of human fibroblasts to pluripotency with lineage specifiers. Cell Stem Cell 2013; 13: 341-350.
47. Shu J, Wu C, Wu Y, et al. Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell 2013; 153: 963-975.