Sustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Chen, Qiuyue ^a   Lee, Ching En ^a   Denard, Bray ^a   Ye, Jin ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN 3 LIKE 1; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TM4SF20; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; COLLAGEN; CREB3L1 PROTEIN, HUMAN; NERVE PROTEIN;

A549 CELL LINE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; GENE ACTIVATION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CELL LINE; CELL MEMBRANE; CELL NUCLEUS; COLLAGEN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; EXTRACELLULAR MATRIX; HUMANS; NERVE TISSUE PROTEINS; PROTEOLYSIS; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84907907056     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108528     Document Type: Article

References (35)

1. Murakami T, Saito A, Hino S-i, Kondo S, Kanemoto S, et al. (2009) Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nat Cell Biol 11: 1205-1211.
2. Denard B, Seemann J, Chen Q, Gay A, Huang H, et al. (2011) The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells. Cell Host & Microbe 10: 65-74.
3. Denard B, Lee C, Ye J (2012) Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1. eLife Sciences 1: 10.7554/eLife.00090.
4. Murakami T, Kondo S, Ogata M, Kanemoto S, Saito A, et al. (2006) Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress. J Neurochem 96: 1090-1100.
5. Brown M, Ye J, Rawson R, Goldstein J (2000) Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100: 391-398.
6. Leask A, Abraham DJ (2004) TGF-β signaling and the fibrotic response. FASEB J 18: 816-827.
7. Loeys BL, Mortier G, Dietz HC (2013) Bone lessons from Marfan syndrome and related disorders: fibrillin, TGF-B and BMP at the balance of too long and too short. Pediatr Endocrinol Rev 10: 417-423.
8. Massague J (2012) TGFβ signalling in context. Nat Rev Mol Cell Biol 13: 616-630.
9. Burch M, Zheng W, Little P (2011) Smad linker region phosphorylation in the regulation of extracellular matrix synthesis. Cell Mol Life Sci 68: 97-107.
10. Verrecchia F, Mauviel A (2007) Transforming growth factor-β and fibrosis. World J Gastroenterol 13: 3056-3062.
11. Derynck R, Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425: 577-584.
12. Holm TM, Habashi JP, Doyle JJ, Bedja D, Chen Y, et al. (2011) Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice. Science 332: 358-361.
13. Wang C, Gale Jr M, Keller BC, Huang H, Brown MS, et al. (2005) Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. Mol Cell 18: 425-434.
14. Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J (1982) Growth of human hepatoma cell lines with differentiated functions in chemically defined medium. Cancer Res 42: 3858-3863.
15. Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, et al. (1996) Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell 85: 1037-1046.
16. Adams CM, Reitz J, De Brabander JK, Feramisco JD, Li L, et al. (2004) Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. J Biol Chem 279: 52772-52780.
17. Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, et al. (2002) Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J Biol Chem 277: 9520-9528.
18. Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, et al. (2003) Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci USA 100: 12027-12032.
19. Kasai H, Allen J, Mason R, Kamimura T, Zhang Z (2005) TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 6: 56-70.
20. Martinek N, Shahab J, Sodek J, Ringuette M (2007) Is SPARC an evolutionarily conserved collagen chaperone? J Dent Res 86: 296-305.
21. Nieto MA (2011) The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu Rev Cell Dev Biol 27: 347-376.
22. Walter P, Ron D (2011) The unfolded protein response: from stress pathway to homeostatic regulation. Science 334: 1081-1086.
23. Brown MS, Goldstein JL (2009) Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. J Lipid Res 50: S15-S27.
24. Tsukita S, Furuse M (2002) Claudin-based barrier in simple and stratified cellular sheets. Curr Opin Cell Biol 14: 531-536.
25. Nguyen VT, Ndoye A, Grando SA (2000) Novel Human α9 Acetylcholine Receptor Regulating Keratinocyte Adhesion is Targeted by Pemphigus Vulgaris Autoimmunity. Am J Pathol 157: 1377-1391.
26. Qi B, Newcomer RG, Sang Q-SA (2009) ADAM19/adamalysin 19 structure, function, and role as a putative target in tumors and inflammatory diseases. Curr Pharm Des 15: 2236-2248.
27. Wright MD, Rudy GB, Ni J (2000) The L6 membrane proteins-A new four-transmembrane superfamily. Protein Sci 9: 1594-1600.
28. Iverson C, Larson G, Lai C, Yeh L-T, Dadson C, et al. (2009) RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res 69: 6839-6847.
29. Thompson N, Lyons J (2005) Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery. Curr Opin Pharmacol 5: 350-356.
30. Habashi JP, Doyle JJ, Holm TM, Aziz H, Schoenhoff F, et al. (2011) Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism. Science 332: 361-365.
31. Massagué J (2008) TGFβ in Cancer. Cell 134: 215-230.
32. Egeblad M, Rasch MG, Weaver VM (2010) Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol 22: 697-706.
33. Rosenbloom J, Castro SV, Jimenez SA (2010) Fibrotic diseases: Cellular and molecular mechanisms and novel therapies. Ann Intern Med 152: 159-166.
34. Hawkins JL, Robbins MD, Warren LC, Xia D, Petras SF, et al. (2008) Pharmacologic inhibition of Site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol Exp Ther 326: 801-808.
35. Olmstead AD, Knecht W, Lazarov I, Dixit SB, Jean F (2012) Human subtilase SKI-1/S1P is a master regulator of the HCV lifecycle and a potential host cell target for developing indirect-acting antiviral agents. PLoS Pathog 8: e1002468.