Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors

Journal of Medicinal Chemistry

Volumn 57, Issue 19, 2014, Pages 7977-7989

  Yang, Zhuang ^a,b   Wu, Wenshuang ^a   Wang, Jingjing ^a   Liu, Li ^b   Li, Luyuan ^c   Yang, Jianhong ^a   Wang, Guangcheng ^a   Cao, Dong ^a   Zhang, Ronghong ^a   Tang, Minghai ^a   Wen, Jiaolin ^a   Zhu, Jun ^a   Xiang, Wei ^a   Wang, Fang ^a   Ma, Liang ^a   Xiang, Mingli ^a   You, Jingsong ^b   Chen, Lijuan ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c NANKAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3 AMINO 4 METHOXYPHENYL) 1 (5 METHOXY 2,2 DIMETHYL 2H CHROMEN 8 YL)PROP 2 EN 1 ONE; ANTINEOPLASTIC AGENT; COLCHICINE; MILLEPACHINE; UNCLASSIFIED DRUG; CHALCONE DERIVATIVE; TUBULIN MODULATOR;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CANCER GROWTH; CANCER RESISTANCE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL MIGRATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROTUBULE ASSEMBLY; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; FLUORESCENT ANTIBODY TECHNIQUE; HEPG2 CELL LINE; MULTIDRUG RESISTANCE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHALCONES; DRUG RESISTANCE, MULTIPLE; FLUORESCENT ANTIBODY TECHNIQUE; HEP G2 CELLS; HUMANS; MICE, INBRED BALB C; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84907897467     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500849z     Document Type: Article

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