Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 7, 2014, Pages 2060-2079

  Wang, Guangcheng ^a   Li, Chunyan ^a   He, Lin ^a   Lei, Kai ^a   Wang, Fang ^a   Pu, Yuzi ^a   Yang, Zhuang ^a,b   Cao, Dong ^a   Ma, Liang ^a   Chen, Jinying ^a   Sang, Yun ^a,b   Liang, Xiaolin ^a   Xiang, Mingli ^a   Peng, Aihua ^a   Wei, Yuquan ^a   Chen, Lijuan ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Chalcone; Indole; Millepachine; Tubulin

Indexed keywords

1 (5 METHOXY 2,2 DIMETHYL 2H CHROMEN 8 YL)ETHANONE; 1 [4 METHOXY 2 [(2 METHYLBUT 3 YN 2 YL)OXY]PHENYL]; 2,2 DIMETHYL 8 [3 (1 METHYL 1H INDOL 5 YL)ACRYLOYL] 2H CHROMEN 5 YL PROPIONATE; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; COLCHICINE; INDOLE DERIVATIVE; PYRANO CHALCONE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; CHALCONE; TUBULIN MODULATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOASSAY; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL TYPE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DOSE COMPARISON; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; LIVER CELL CARCINOMA; MOLECULAR DOCKING; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PROTEIN POLYMERIZATION; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; CELL CYCLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HEPG2 CELL LINE; METABOLISM; NEOPLASMS, EXPERIMENTAL; NUDE MOUSE; POLYMERIZATION; SYNTHESIS;

MUS MUSCULUS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; CHALCONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HEP G2 CELLS; HUMANS; INDOLES; MICE; MICE, INBRED BALB C; MICE, NUDE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; POLYMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 84897400401     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.02.028     Document Type: Article

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