메뉴 건너뛰기




Volumn 90, Issue 1, 2014, Pages 225-236

Synbiotic Lactobacillus acidophilus NCFM and cellobiose does not affect human gut bacterial diversity but increases abundance of lactobacilli, bifidobacteria and branched-chain fatty acids: A randomized, double-blinded cross-over trial

Author keywords

Bifidobacterium; Lactobacillus; Branched chain fatty acids; Human trial; Microbial community sequencing; Synbiotics

Indexed keywords

BACTERIA (MICROORGANISMS); BIFIDOBACTERIUM; LACTOBACILLUS; LACTOBACILLUS ACIDOPHILUS NCFM;

EID: 84907895037     PISSN: 01686496     EISSN: 15746941     Source Type: Journal    
DOI: 10.1111/1574-6941.12397     Document Type: Article
Times cited : (49)

References (63)
  • 1
    • 17644389315 scopus 로고    scopus 로고
    • Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM
    • Altermann E, Russel MW, Azcarate-Peril AM et al. (2005) Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. P Natl Acad Sci USA 102: 3906-3912.
    • (2005) P Natl Acad Sci USA , vol.102 , pp. 3906-3912
    • Altermann, E.1    Russel, M.W.2    Azcarate-Peril, A.M.3
  • 3
    • 11144238567 scopus 로고    scopus 로고
    • Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis, and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria
    • Bartosch S, Woodmansey EJ, Paterson JCM, McMurdo MET & Macfarlane GT (2005) Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis, and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria. Clin Infect Dis 40: 28-37.
    • (2005) Clin Infect Dis , vol.40 , pp. 28-37
    • Bartosch, S.1    Woodmansey, E.J.2    Paterson, J.C.M.3    McMurdo, M.E.T.4    Macfarlane, G.T.5
  • 4
    • 84866497902 scopus 로고    scopus 로고
    • Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol
    • Björklund M, Ouwehand AC, Forssten SD, Nikkilä J, Tiihonen K, Rautonen N & Lahtinen SJ (2011) Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol. Age 34: 987-999.
    • (2011) Age , vol.34 , pp. 987-999
    • Björklund, M.1    Ouwehand, A.C.2    Forssten, S.D.3    Nikkilä, J.4    Tiihonen, K.5    Rautonen, N.6    Lahtinen, S.J.7
  • 5
    • 0021256014 scopus 로고
    • Studies of stools from pseudomembranous colitis, rotaviral, and other diarrheal syndromes by frequency-pulsed electron capture gas-liquid chromatography
    • Brooks JB, Nunez-Montiel OL, Basta MT & Hierholzer JC (1984) Studies of stools from pseudomembranous colitis, rotaviral, and other diarrheal syndromes by frequency-pulsed electron capture gas-liquid chromatography. J Clin Microbiol 20: 549-560.
    • (1984) J Clin Microbiol , vol.20 , pp. 549-560
    • Brooks, J.B.1    Nunez-Montiel, O.L.2    Basta, M.T.3    Hierholzer, J.C.4
  • 6
    • 77952243141 scopus 로고    scopus 로고
    • qiime allows analysis of high-throughput community sequencing data
    • Caporaso JG, Kuczynski J, Stombaugh J et al. (2010) qiime allows analysis of high-throughput community sequencing data. Nat Methods 7: 335-336.
    • (2010) Nat Methods , vol.7 , pp. 335-336
    • Caporaso, J.G.1    Kuczynski, J.2    Stombaugh, J.3
  • 8
    • 0034786792 scopus 로고    scopus 로고
    • The action of starch synthase II on 6″′-α-maltotriosyl-maltohexaose comprising the branch point of amylopectin
    • Damager I, Denyer K, Motawia MS, Møller BL & Blennow A (2001) The action of starch synthase II on 6″′-α-maltotriosyl-maltohexaose comprising the branch point of amylopectin. Eur J Biochem 268: 4878-4884.
    • (2001) Eur J Biochem , vol.268 , pp. 4878-4884
    • Damager, I.1    Denyer, K.2    Motawia, M.S.3    Møller, B.L.4    Blennow, A.5
  • 9
    • 80053150201 scopus 로고    scopus 로고
    • Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans
    • Davis LMG, Martínez I, Walter J, Goin C & Hutkins RW (2011) Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans. PLoS One 6: e25200.
    • (2011) PLoS One , vol.6 , pp. e25200
    • Davis, L.M.G.1    Martínez, I.2    Walter, J.3    Goin, C.4    Hutkins, R.W.5
  • 10
    • 79955618774 scopus 로고    scopus 로고
    • Impact of the synbiotic combination of Lactobacillus casei shirota and oligofructose-enriched inulin on the fecal volatile metabolite profile in healthy subjects
    • De Preter V, Ghebretinsae AH, Abrahantes JC, Windey K, Rutgeerts P & Verbeke K (2011) Impact of the synbiotic combination of Lactobacillus casei shirota and oligofructose-enriched inulin on the fecal volatile metabolite profile in healthy subjects. Mol Nutr Food Res 55: 714-722.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 714-722
    • De Preter, V.1    Ghebretinsae, A.H.2    Abrahantes, J.C.3    Windey, K.4    Rutgeerts, P.5    Verbeke, K.6
  • 12
    • 0141628734 scopus 로고    scopus 로고
    • The effect of Lactobacillus plantarum 299v on the bacterial composition and metabolic activity in faeces of healthy volunteers : a placebo-controlled study on the onset and duration of effects
    • Goossen DS, Jonker DS, Russel M, Stobberingh E, van den Bogaard AEJM & Stockbrügger R (2003) The effect of Lactobacillus plantarum 299v on the bacterial composition and metabolic activity in faeces of healthy volunteers : a placebo-controlled study on the onset and duration of effects. Aliment Pharmacol Ther 18: 495-505.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 495-505
    • Goossen, D.S.1    Jonker, D.S.2    Russel, M.3    Stobberingh, E.4    van den Bogaard, A.E.J.M.5    Stockbrügger, R.6
  • 13
    • 10744231343 scopus 로고    scopus 로고
    • Effects of wheat pentosan and inulin on the metabolic activity of fecal microbiota and on bowel function in healthy humans
    • Gråsten S, Liukkonen K-H, Chrevatidis A, El-Nezami H, Poutanen K & Mykkänen H (2003) Effects of wheat pentosan and inulin on the metabolic activity of fecal microbiota and on bowel function in healthy humans. Nutr Res 23: 1503-1514.
    • (2003) Nutr Res , vol.23 , pp. 1503-1514
    • Gråsten, S.1    Liukkonen, K.-H.2    Chrevatidis, A.3    El-Nezami, H.4    Poutanen, K.5    Mykkänen, H.6
  • 14
    • 0036139245 scopus 로고    scopus 로고
    • Molecular diversity of Lactobacillus spp. and other lactic acid bacteria in the human intestine as determined by specific amplification of 16S ribosomal DNA
    • Heilig HGHJ, Zoetendal EG, Vaughan EE, Marteau P, Akkermans ADL & de Vos WM (2002) Molecular diversity of Lactobacillus spp. and other lactic acid bacteria in the human intestine as determined by specific amplification of 16S ribosomal DNA. Appl Environ Microbiol 68: 114-123.
    • (2002) Appl Environ Microbiol , vol.68 , pp. 114-123
    • Heilig, H.G.H.J.1    Zoetendal, E.G.2    Vaughan, E.E.3    Marteau, P.4    Akkermans, A.D.L.5    de Vos, W.M.6
  • 15
    • 0036690693 scopus 로고    scopus 로고
    • Phylogenetic analysis of intestinal microflora indicates a novel Mycoplasma phylotype in farmed and wild salmon
    • Holben WE, Williams P, Gilbert MA, Saarinen M, Särkilahti LK & Apajalahti JHA (2002) Phylogenetic analysis of intestinal microflora indicates a novel Mycoplasma phylotype in farmed and wild salmon. Microb Ecol 44: 175-185.
    • (2002) Microb Ecol , vol.44 , pp. 175-185
    • Holben, W.E.1    Williams, P.2    Gilbert, M.A.3    Saarinen, M.4    Särkilahti, L.K.5    Apajalahti, J.H.A.6
  • 17
    • 85056037203 scopus 로고    scopus 로고
    • The impact of the level of the intestinal short chain fatty acids in inflammatory bowel disease patients versus healthy subjects
    • Huda-Faujan N, Abdulamir AS, Fatimah AB, Anas OM, Shuhaimi M, Yazid AM & Loong YY (2010) The impact of the level of the intestinal short chain fatty acids in inflammatory bowel disease patients versus healthy subjects. Open Biochem J 4: 53-58.
    • (2010) Open Biochem J , vol.4 , pp. 53-58
    • Huda-Faujan, N.1    Abdulamir, A.S.2    Fatimah, A.B.3    Anas, O.M.4    Shuhaimi, M.5    Yazid, A.M.6    Loong, Y.Y.7
  • 20
    • 79955492016 scopus 로고    scopus 로고
    • A probiotic mixture including galactooligosaccharides decreases fecal β-glucosidase activity but does not affect serum enterolactone concentration in men during a two-week intervention
    • Kekkonen RA, Holma R, Hatakka K, Suomalainen T, Poussa T, Adlercreutz H & Korpela R (2011) A probiotic mixture including galactooligosaccharides decreases fecal β-glucosidase activity but does not affect serum enterolactone concentration in men during a two-week intervention. J Nutr 141: 870-876.
    • (2011) J Nutr , vol.141 , pp. 870-876
    • Kekkonen, R.A.1    Holma, R.2    Hatakka, K.3    Suomalainen, T.4    Poussa, T.5    Adlercreutz, H.6    Korpela, R.7
  • 21
    • 84881478467 scopus 로고    scopus 로고
    • Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing
    • Kim S-W, Suda W, Kim S, Oshima K, Fukuda S, Ohno H, Morita H & Hattori M (2013) Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing. DNA Res 20: 241-253.
    • (2013) DNA Res , vol.20 , pp. 241-253
    • Kim, S.-W.1    Suda, W.2    Kim, S.3    Oshima, K.4    Fukuda, S.5    Ohno, H.6    Morita, H.7    Hattori, M.8
  • 22
    • 37849013482 scopus 로고    scopus 로고
    • The effect of a multispecies probiotic on the intestinal microbiota and bowel movements in healthy volunteers taking the antibiotic amoxycillin
    • Koning CJM, Jonkers DMAE, Stobberingh EE, Mulder L, Rombouts FM & Stockbrügger RW (2008) The effect of a multispecies probiotic on the intestinal microbiota and bowel movements in healthy volunteers taking the antibiotic amoxycillin. Am J Gastroentrol 103: 178-189.
    • (2008) Am J Gastroentrol , vol.103 , pp. 178-189
    • Koning, C.J.M.1    Jonkers, D.M.A.E.2    Stobberingh, E.E.3    Mulder, L.4    Rombouts, F.M.5    Stockbrügger, R.W.6
  • 23
    • 84877116806 scopus 로고    scopus 로고
    • Associations between the human intestinal microbiota, Lactobacillus rhamnosus GG and serum lipids indicated by integrated analysis of high-throughput profiling data
    • Lahti L, Salonen A, Kekkonen RA, Salojärvi J, Jalanka-Tuovinen J, Palva A, Orešič M & de Vos WM (2013) Associations between the human intestinal microbiota, Lactobacillus rhamnosus GG and serum lipids indicated by integrated analysis of high-throughput profiling data. PeerJ 1: e32.
    • (2013) PeerJ , vol.1 , pp. e32
    • Lahti, L.1    Salonen, A.2    Kekkonen, R.A.3    Salojärvi, J.4    Jalanka-Tuovinen, J.5    Palva, A.6    Orešič, M.7    de Vos, W.M.8
  • 24
    • 77949393654 scopus 로고    scopus 로고
    • Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults
    • Larsen N, Vogensen FK, van den Berg FWJ et al. (2010) Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 5: e9085.
    • (2010) PLoS One , vol.5 , pp. e9085
    • Larsen, N.1    Vogensen, F.K.2    van den Berg, F.W.J.3
  • 25
    • 78751698624 scopus 로고    scopus 로고
    • Predominant genera of fecal microbiota in children with atopic dermatitis are not altered by intake of probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07
    • Larsen N, Vogensen FK, Gøbel R, Michaelsen KF, Abu Al-Soud W, Sørensen SJ, Hansen LH & Jakobsen M (2011) Predominant genera of fecal microbiota in children with atopic dermatitis are not altered by intake of probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07. FEMS Microbiol Ecol 75: 482-496.
    • (2011) FEMS Microbiol Ecol , vol.75 , pp. 482-496
    • Larsen, N.1    Vogensen, F.K.2    Gøbel, R.3    Michaelsen, K.F.4    Abu Al-Soud, W.5    Sørensen, S.J.6    Hansen, L.H.7    Jakobsen, M.8
  • 27
    • 33845901507 scopus 로고    scopus 로고
    • Human gut microbes associated with obesity
    • Ley RE, Turnbaugh PJ, Klein S & Gordon JI (2006) Human gut microbes associated with obesity. Nature 444: 1022-1023.
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 29
    • 85047689124 scopus 로고    scopus 로고
    • Bacteria, colonic fermentation, and gastrointestinal health
    • Macfarlane GT & Macfarlane S (2012) Bacteria, colonic fermentation, and gastrointestinal health. J AOAC Int 95: 50-60.
    • (2012) J AOAC Int , vol.95 , pp. 50-60
    • Macfarlane, G.T.1    Macfarlane, S.2
  • 30
    • 84883473232 scopus 로고    scopus 로고
    • Synbiotic consumption changes the metabolism and composition of the gut microbiota in older people and modifies inflammatory processes: a randomised, double-blind, placebo-controlled crossover study
    • Macfarlane S, Cleary S, Bahrami B, Reynolds N & Macfarlane GT (2013) Synbiotic consumption changes the metabolism and composition of the gut microbiota in older people and modifies inflammatory processes: a randomised, double-blind, placebo-controlled crossover study. Aliment Pharmacol Ther 38: 804-816.
    • (2013) Aliment Pharmacol Ther , vol.38 , pp. 804-816
    • Macfarlane, S.1    Cleary, S.2    Bahrami, B.3    Reynolds, N.4    Macfarlane, G.T.5
  • 31
    • 78649734540 scopus 로고    scopus 로고
    • Resistant starches types 2 and 4 have differential effects on the composition of the fecal microbiota in human subjects
    • Martínez I, Kim J, Duffy PR, Schlegel VL & Walter J (2010) Resistant starches types 2 and 4 have differential effects on the composition of the fecal microbiota in human subjects. PLoS One 5: e15046.
    • (2010) PLoS One , vol.5 , pp. e15046
    • Martínez, I.1    Kim, J.2    Duffy, P.R.3    Schlegel, V.L.4    Walter, J.5
  • 32
    • 78651426431 scopus 로고    scopus 로고
    • Characterization of bacterial populations in Danish raw milk cheeses made with different starter cultures by denaturating gradient gel electrophoresis and pyrosequencing
    • Masoud W, Takamiya M, Vogensen FK, Lillevang S, Al-Soud WA, Sørensen SJ & Jakobsen M (2011) Characterization of bacterial populations in Danish raw milk cheeses made with different starter cultures by denaturating gradient gel electrophoresis and pyrosequencing. Int Dairy J 21: 142-148.
    • (2011) Int Dairy J , vol.21 , pp. 142-148
    • Masoud, W.1    Takamiya, M.2    Vogensen, F.K.3    Lillevang, S.4    Al-Soud, W.A.5    Sørensen, S.J.6    Jakobsen, M.7
  • 33
    • 80054960299 scopus 로고    scopus 로고
    • The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins
    • McNulty NP, Yatsunenko T, Hsiao A et al. (2011) The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins. Sci Transl Med 3: 106ra106.
    • (2011) Sci Transl Med , vol.3 , pp. 106ra106
    • McNulty, N.P.1    Yatsunenko, T.2    Hsiao, A.3
  • 34
    • 84862818682 scopus 로고    scopus 로고
    • Women with and without metabolic disorder differ in their gut microbiota composition
    • Munukka E, Wiklund P, Pekkala S et al. (2012) Women with and without metabolic disorder differ in their gut microbiota composition. Obesity 20: 1082-1087.
    • (2012) Obesity , vol.20 , pp. 1082-1087
    • Munukka, E.1    Wiklund, P.2    Pekkala, S.3
  • 35
    • 9244265519 scopus 로고    scopus 로고
    • Bioavailability of cellobiose by tolerance test and breath hydrogen excretion in humans
    • Nakamura S, Oku T & Ichinose M (2004) Bioavailability of cellobiose by tolerance test and breath hydrogen excretion in humans. Nutrition 20: 979-983.
    • (2004) Nutrition , vol.20 , pp. 979-983
    • Nakamura, S.1    Oku, T.2    Ichinose, M.3
  • 36
    • 68749086014 scopus 로고    scopus 로고
    • Effect of a synbiotic food consumption on human gut metabolic profiles evaluated by (1)H Nuclear Magnetic Resonance spectroscopy
    • Ndagijimana M, Laghi L, Vitali B, Placucci G, Brigidi P & Guerzoni ME (2009) Effect of a synbiotic food consumption on human gut metabolic profiles evaluated by (1)H Nuclear Magnetic Resonance spectroscopy. Int J Food Microbiol 134: 147-153.
    • (2009) Int J Food Microbiol , vol.134 , pp. 147-153
    • Ndagijimana, M.1    Laghi, L.2    Vitali, B.3    Placucci, G.4    Brigidi, P.5    Guerzoni, M.E.6
  • 37
    • 49349084076 scopus 로고    scopus 로고
    • Dietary supplementation with beta-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects
    • Nilsson U, Johansson M, Nilsson A, Björck I & Nyman M (2008) Dietary supplementation with beta-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects. Eur J Clin Nutr 62: 978-984.
    • (2008) Eur J Clin Nutr , vol.62 , pp. 978-984
    • Nilsson, U.1    Johansson, M.2    Nilsson, A.3    Björck, I.4    Nyman, M.5
  • 38
    • 66849131399 scopus 로고    scopus 로고
    • Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters
    • Ouwehand AC, Tiihonen K, Saarinen M, Putaala H & Rautonen N (2009) Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters. Br J Nutr 101: 367-375.
    • (2009) Br J Nutr , vol.101 , pp. 367-375
    • Ouwehand, A.C.1    Tiihonen, K.2    Saarinen, M.3    Putaala, H.4    Rautonen, N.5
  • 39
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • Qin J, Li Y, Cai Z et al. (2012) A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490: 55-60.
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.1    Li, Y.2    Cai, Z.3
  • 40
    • 82255162672 scopus 로고    scopus 로고
    • Gut microbiota and the role of probiotics in therapy
    • Quigley EMM (2011) Gut microbiota and the role of probiotics in therapy. Curr Opin Pharmacol 11: 593-603.
    • (2011) Curr Opin Pharmacol , vol.11 , pp. 593-603
    • Quigley, E.M.M.1
  • 41
    • 78149272756 scopus 로고    scopus 로고
    • Prebiotic effects: metabolic and health benefits
    • Roberfroid M, Gibson GR, Hoyles L et al. (2010) Prebiotic effects: metabolic and health benefits. Br J Nutr 104(suppl): S1-S63.
    • (2010) Br J Nutr , vol.104 , Issue.suppl , pp. S1-S63
    • Roberfroid, M.1    Gibson, G.R.2    Hoyles, L.3
  • 42
    • 84856229449 scopus 로고    scopus 로고
    • The effect of probiotics on faecal microbiota and genotoxic activity of faecal water in patients with atopic dermatitis: a randomized, placebo-controlled study
    • Roessler A, Forssten SD, Glei M, Ouwehand AC & Jahreis G (2011) The effect of probiotics on faecal microbiota and genotoxic activity of faecal water in patients with atopic dermatitis: a randomized, placebo-controlled study. Clin Nutr 31: 22-29.
    • (2011) Clin Nutr , vol.31 , pp. 22-29
    • Roessler, A.1    Forssten, S.D.2    Glei, M.3    Ouwehand, A.C.4    Jahreis, G.5
  • 43
    • 80054124764 scopus 로고    scopus 로고
    • Impact of probiotics on colonizing microbiota of the gut
    • Sanders ME (2011) Impact of probiotics on colonizing microbiota of the gut. J Clin Gastroenterol 45(Suppl): S115-S119.
    • (2011) J Clin Gastroenterol , vol.45 , Issue.Suppl , pp. S115-S119
    • Sanders, M.E.1
  • 44
    • 0035259025 scopus 로고    scopus 로고
    • The scientific basis of Lactobacillus acidophilus NCFM functionality as a probiotic
    • Sanders ME & Klaenhammer TR (2001) The scientific basis of Lactobacillus acidophilus NCFM functionality as a probiotic. J Dairy Sci 84: 319-331.
    • (2001) J Dairy Sci , vol.84 , pp. 319-331
    • Sanders, M.E.1    Klaenhammer, T.R.2
  • 45
    • 22244466405 scopus 로고    scopus 로고
    • Influence of disaccharide structure on prebiotic selectivity in vitro
    • Sanz ML, Gibson GR & Rastall RA (2005) Influence of disaccharide structure on prebiotic selectivity in vitro. J Agric Food Chem 53: 5192-5199.
    • (2005) J Agric Food Chem , vol.53 , pp. 5192-5199
    • Sanz, M.L.1    Gibson, G.R.2    Rastall, R.A.3
  • 48
    • 4444242774 scopus 로고    scopus 로고
    • Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens
    • Servin AL (2004) Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens. FEMS Microbiol Rev 28: 405-440.
    • (2004) FEMS Microbiol Rev , vol.28 , pp. 405-440
    • Servin, A.L.1
  • 49
    • 77952241142 scopus 로고    scopus 로고
    • The effects of a synbiotic fermented milk beverage containing Lactobacillus casei strain Shirota and transgalactosylated oligosaccharides on defecation frequency, intestinal microflora, organic acid concentrations, and putrefactive metabolites of s
    • Shioiri T, Yahagi K, Nakamaya S et al. (2006) The effects of a synbiotic fermented milk beverage containing Lactobacillus casei strain Shirota and transgalactosylated oligosaccharides on defecation frequency, intestinal microflora, organic acid concentrations, and putrefactive metabolites of s. BioSci Microflora 25: 137-146.
    • (2006) BioSci Microflora , vol.25 , pp. 137-146
    • Shioiri, T.1    Yahagi, K.2    Nakamaya, S.3
  • 50
    • 69949111703 scopus 로고    scopus 로고
    • The core gut microbiome, energy balance and obesity
    • Turnbaugh PJ & Gordon JI (2009) The core gut microbiome, energy balance and obesity. J Physiol 587: 4153-4158.
    • (2009) J Physiol , vol.587 , pp. 4153-4158
    • Turnbaugh, P.J.1    Gordon, J.I.2
  • 51
    • 12444257329 scopus 로고    scopus 로고
    • Effect of Lactobacillus rhamnosus KY-3 and cellobiose as synbiotics on lipid metabolism in rats
    • Umeki M, Oue K, Mochizuki S, Shirai Y & Sakai K (2004) Effect of Lactobacillus rhamnosus KY-3 and cellobiose as synbiotics on lipid metabolism in rats. J Nutr Sci Vitaminol 50: 330-334.
    • (2004) J Nutr Sci Vitaminol , vol.50 , pp. 330-334
    • Umeki, M.1    Oue, K.2    Mochizuki, S.3    Shirai, Y.4    Sakai, K.5
  • 52
    • 37849189432 scopus 로고    scopus 로고
    • Fluorescent in situ hybridization analysis of cecal microflora in rats simultaneously administrated Lactobacillus rhamnosus KY-3 and cellobiose
    • Umeki M, Oue K, Mori M, Mochizuki S & Sakai K (2005) Fluorescent in situ hybridization analysis of cecal microflora in rats simultaneously administrated Lactobacillus rhamnosus KY-3 and cellobiose. Food Sci Technol Res 11: 168-170.
    • (2005) Food Sci Technol Res , vol.11 , pp. 168-170
    • Umeki, M.1    Oue, K.2    Mori, M.3    Mochizuki, S.4    Sakai, K.5
  • 53
    • 1842608597 scopus 로고    scopus 로고
    • The metabolic activity of fecal microbiota from healthy individuals and patients with inflammatory bowel disease
    • van Nuenen MHMC, Venema K, van der Woude JCJ & Kuipers EJ (2004) The metabolic activity of fecal microbiota from healthy individuals and patients with inflammatory bowel disease. Dig Dis Sci 49: 485-491.
    • (2004) Dig Dis Sci , vol.49 , pp. 485-491
    • van Nuenen, M.H.M.C.1    Venema, K.2    van der Woude, J.C.J.3    Kuipers, E.J.4
  • 57
    • 0035374627 scopus 로고    scopus 로고
    • Detection of Lactobacillus, Pediococcus, Leuconostoc and Weissella species in human feces by using group-specific PCR primers and denaturing gradient gel electrophoresis
    • Walter J, Hertel C, Tannock GW, Lis CM, Munro K & Hammes WP (2001) Detection of Lactobacillus, Pediococcus, Leuconostoc and Weissella species in human feces by using group-specific PCR primers and denaturing gradient gel electrophoresis. Appl Environ Microbiol 67: 2578-2585.
    • (2001) Appl Environ Microbiol , vol.67 , pp. 2578-2585
    • Walter, J.1    Hertel, C.2    Tannock, G.W.3    Lis, C.M.4    Munro, K.5    Hammes, W.P.6
  • 58
    • 77953565999 scopus 로고    scopus 로고
    • Transcriptional analysis of genes associated with stress and adhesion in Lactobacillus acidophilus NCFM during the passage through an in vitro gastrointestinal tract model
    • Weiss G & Jespersen L (2010) Transcriptional analysis of genes associated with stress and adhesion in Lactobacillus acidophilus NCFM during the passage through an in vitro gastrointestinal tract model. J Mol Microbiol Biotechnol 18: 206-214.
    • (2010) J Mol Microbiol Biotechnol , vol.18 , pp. 206-214
    • Weiss, G.1    Jespersen, L.2
  • 59
    • 84855310228 scopus 로고    scopus 로고
    • Relevance of protein fermentation to gut health
    • Windey K, De Preter V & Verbeke K (2012) Relevance of protein fermentation to gut health. Mol Nutr Food Res 56: 184-196.
    • (2012) Mol Nutr Food Res , vol.56 , pp. 184-196
    • Windey, K.1    De Preter, V.2    Verbeke, K.3
  • 61
    • 70349570169 scopus 로고    scopus 로고
    • A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic and synbiotics supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer
    • Worthley DL, Le Leu RK, Whitehall VL et al. (2009) A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic and synbiotics supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer. Am J Clin Nutr 90: 578-586.
    • (2009) Am J Clin Nutr , vol.90 , pp. 578-586
    • Worthley, D.L.1    Le Leu, R.K.2    Whitehall, V.L.3
  • 62
    • 16344363305 scopus 로고    scopus 로고
    • Group-specific primer and probe sets to detect methanogenic communities using quantitative real-time polymerase chain reaction
    • Yu Y, Lee C, Kim J & Hwang S (2005) Group-specific primer and probe sets to detect methanogenic communities using quantitative real-time polymerase chain reaction. Biotechnol Bioeng 89: 670-679.
    • (2005) Biotechnol Bioeng , vol.89 , pp. 670-679
    • Yu, Y.1    Lee, C.2    Kim, J.3    Hwang, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.