Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: Implications for drug-induced osteomalacia

Journal of Bone and Mineral Research

Volumn 28, Issue 5, 2013, Pages 1101-1116

  Wang, Zhican ^a   Lin, Yvonne S ^a   Dickmann, Leslie J ^c   Poulton, Emma Jane ^a   Eaton, David L ^a   Lampe, Johanna W ^d   Shen, Danny D ^a   Davis, Connie L ^b   Shuhart, Margaret C ^a   Thummel, Kenneth E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Department of Pharmacokinetics and Drug Metabolism   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

Author keywords

25 Hydroxyvitamin D3; Cytochrome P450 24A1; Cytochrome P450 3A4; Osteomalacia; Pregnane X Receptor

Indexed keywords

CALCIFEDIOL; CARBAMAZEPINE; CYTOCHROME P450 3A4; HYPERFORIN; PHENOBARBITAL; RIFAMPICIN; SULFORAPHANE;

ADULT; AEROBIC METABOLISM; ARTICLE; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYDROXYLATION; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MALE; NORMAL HUMAN; OSTEOMALACIA; PROTEIN EXPRESSION;

ADULT; CALCIFEDIOL; CELL LINE; CYTOCHROME P-450 CYP3A; ENZYME INDUCTION; FEMALE; HUMANS; HYDROXYLATION; LIVER; MALE; MIDDLE AGED; OSTEOMALACIA; RIFAMPIN; YOUNG ADULT;

EID: 84876720172     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1839     Document Type: Article

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