Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: Impact on modeling CYP3A-mediated drug-drug interactionss

Drug Metabolism and Disposition

Volumn 41, Issue 8, 2013, Pages 1566-1574

  Shirasaka, Yoshiyuki ^a   Chang, Shu Ying ^b   Grubb, Mary F ^b   Peng, Chi Chi ^a   Thummel, Kenneth E ^a   Isoherranen, Nina ^a   Rodrigues, A David ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; ITRACONAZOLE; KETOCONAZOLE; MIDAZOLAM; RECOMBINANT CYTOCHROME P450 3A; RECOMBINANT CYTOCHROME P450 3A5; RECOMBINANT ENZYME; TERFENADINE; TESTOSTERONE; UNCLASSIFIED DRUG; VINCRISTINE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG INTERACTION; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME SUBSTRATE COMPLEX; FEMALE; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; IN VITRO STUDY; INHIBITION KINETICS; LIVER MICROSOME; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIMULATION;

BIOCATALYSIS; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; FEMALE; GENOTYPE; HUMANS; ITRACONAZOLE; KETOCONAZOLE; MALE; MICROSOMES, LIVER; MIDAZOLAM; TERFENADINE; TESTOSTERONE; VINCRISTINE;

EID: 84880681749     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.049940     Document Type: Article

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