The immunology of delirium

NeuroImmunoModulation

Volumn 21, Issue 2-3, 2014, Pages 72-78

  Cerejeira, Joaquim ^a,b   Lagarto, Luísa ^a   Mukaetova Ladinska, Elizabeta B ^c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Delirium; Immune response; Inflammation

Indexed keywords

CYTOKINE; HYDROCORTISONE;

ARTICLE; CHOLINERGIC SYSTEM; CYTOKINE PRODUCTION; DELIRIUM; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNE RESPONSE; IMMUNOLOGY; INFLAMMATION; LOCUS CERULEUS; MICROGLIA; MOTONEURON NUCLEUS; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; BRAIN; PATHOLOGY; REVIEW;

ANIMALS; BRAIN; DELIRIUM; HUMANS; INFLAMMATION;

EID: 84907867916     PISSN: 10217401     EISSN: 14230216     Source Type: Journal    
DOI: 10.1159/000356526     Document Type: Article

References (48)

1. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4, Text Revision. Washington, American Psychiatric Association, 2000.
2. Cerejeira J, Mukaetova-Ladinska EB: A clinical update on delirium: from early recognition to effective management. Nurs Res Pract 2011; 2011: 875196.
3. Witlox J, Eurelings LS, de Jonghe JF, Kalisvaart KJ, Eikelenboom P, van Gool WA: Delirium in elderly patients and the risk of postdischarge mortality, institutionalization and dementia: a meta-analysis. JAMA 2010; 304: 443-451.
4. Davis DH, Muniz Terrera G, Keage H, Rahkonen T, Oinas M, Matthews FE, Cunningham C, Polvikoski T, Sulkava R, MacLullich AM, Brayne C: Delirium is a strong risk factor for dementia in the oldest-old: a populationbased cohort study. Brain 2012; 135(pt 9):2809-2816.
5. Fong TG, Jones RN, Shi P, Marcantonio ER, Yap L, Rudolph JL, Yang FM, Kiely DK, Inouye SK: Delirium accelerates cognitive decline in Alzheimer disease. Neurology 2009; 72: 1570-1575.
6. Sakai A: Phrenitis: inflammation of the mind and the body. Hist Psychiatry 1991; 2: 193-205.
7. Berrios GE: Delirium and confusion in the 19th century: a conceptual history. Br J Psychiatry 1981; 139: 439-449.
8. Nguyen MD, Julien JP, Rivest S: Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci 2002; 3: 216-227.
9. Barton GM: A calculated response: control of inflammation by the innate immune system. J Clin Invest 2008; 118: 413-420.
10. Weichhart T, Haidinger M, Hrl WH, Säemann MD: Current concepts of molecular defence mechanisms operative during urinary tract infection. Eur J Clin Invest 2008; 38 (suppl 2):29-38.
11. Downing JE, Miyan JA: Neural immunoregulation: emerging roles for nerves in immune homeostasis and disease. Immunol Today 2000; 21: 281-289.
12. Matsumura K, Kobayashi S: Signaling the brain in inflammation: the role of endothelial cells. Front Biosci 2004; 9: 2819-2826.
13. Perry VH: Contribution of systemic inflammation to chronic neurodegeneration. Acta Neuropathol 2010; 120: 277-286.
14. D'Mello C, Le T, Swain MG: Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factor-α signaling during peripheral organ inflammation. J Neurosci 2009; 29: 2089-2102.
15. Norden DM, Godbout JP: Review: microglia of the aged brain: primed to be activated and resistant to regulation. Neuropathol Appl Neurobiol 2013; 39: 19-34.
16. Frank MG, Barrientos RM, Biedenkapp JC, Rudy JW, Watkins LR, Maier SF: mRNA upregulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Neurobiol Aging 2006; 27: 717-722.
17. Sparkman NL, Johnson RW: Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation 2008; 15: 323-330.
18. Wynne AM, Henry CJ, Huang Y, Cleland A, Godbout JP: Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge. Brain Behav Immun 2010; 24: 1190-1201.
19. Harry GJ: Microglia during development and aging. Pharmacol Ther 2013; 139: 313-326.
20. Turnbull AV, Rivier CL: Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiol Rev 1999; 79: 1-71.
21. John CD, Buckingham JC: Cytokines: regulation of the hypothalamo-pituitary-adrenocortical axis. Curr Opin Pharmacol 2003; 3: 78-84.
22. Knoops AJ, van der Graaf Y, Mali WP, Geerlings MI: Age-related changes in hypothalamic-pituitary-adrenal axis activity in patients with manifest arterial disease. Endocrine 2010; 37: 231-238.
23. Robertsson B, Blennow K, Brne G, Edman A, Karlsson I, Wallin A, Gottfries CG: Hyperactivity in the hypothalamic-pituitary-adrenal axis in demented patients with delirium. Int Clin Psychopharmacol 2001; 16: 39-47.
24. O'Brien JT, Ames D, Schweitzer I, Mastwyk M, Colman P: Enhanced adrenal sensitivity to adrenocorticotrophic hormone (ACTH) is evidence of HPA axis hyperactivity in Alzheimer's disease. Psychol Med 1996; 26: 7-14.
25. Hatzinger M, Brand S, Herzig N, Holsboer-Trachsler E: In healthy young and elderly adults, hypothalamic-pituitary-adrenocortical axis reactivity (HPA AR) varies with increasing pharmacological challenge and with age, but not with gender. J Psychiatr Res 2011; 45: 1373-1380.
26. Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES: The sympathetic nerve-anintegrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000; 52: 595-638.
27. Sternberg EM: Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nat Rev Immunol 2006; 6: 318-328.
28. Rosas-Ballina M, Tracey KJ: Cholinergic control of inflammation. J Intern Med 2009; 265: 663-679.
29. McCusker RH, Kelley KW: Immune-neural connections: how the immune system's response to infectious agents influences behavior. J Exp Biol 2013; 216(pt 1):84-98.
30. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW: From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008; 9: 46-56.
31. Cunningham C, Campion S, Lunnon K, Murray CL, Woods JF, Deacon RM, Rawlins JN, Perry VH: Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biol Psychiatry 2009; 65: 304-312.
32. Field RH, Gossen A, Cunningham C: Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium. J Neurosci 2012; 32: 6288-6294.
33. Murray C, Sanderson DJ, Barkus C, Deacon RM, Rawlins JN, Bannerman DM, Cunningham C: Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiol Aging 2012; 33: 603-616.e3.
34. Macdonald A, Adamis D, Treloar A, Martin F: C-reactive protein levels predict the incidence of delirium and recovery from it. Age Ageing 2007; 36: 222-225.
35. Burkhart CS, Dell-Kuster S, Gamberini M, Moeckli A, Grapow M, Filipovic M, Seeberger MD, Monsch AU, Strebel SP, Steiner LA: Modifiable and nonmodifiable risk factors for postoperative delirium after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth 2010; 24: 555-559.
36. de Rooij SE, van Munster BC, Korevaar JC, Levi M: Cytokines and acute phase response in delirium. J Psychosom Res 2007; 62: 521-525.
37. Adamis D, Treloar A, Martin FC, Gregson N, Hamilton G, Macdonald AJ: APOE and cytokines as biological markers for recovery of prevalent delirium in elderly medical inpatients. Int J Geriatr Psychiatry 2007; 22: 688-694.
38. Adamis D, Lunn M, Martin FC, Treloar A, Gregson N, Hamilton G, Macdonald AJ: Cytokines and IGF-I in delirious and non-delirious acutely ill older medical inpatients. Age Ageing 2009; 38: 326-332.
39. MacLullich AM, Edelshain BT, Hall RJ, de Vries A, Howie SE, Pearson A, Middleton SD, Gillies F, Armstrong IR, White TO, Cunningham C, de Rooij SE, van Munster BC: Cerebrospinal fluid interleukin-8 levels are higher in people with hip fracture with perioperative delirium than in controls. J Am Geriatr Soc 2011; 59: 1151-1153.
40. Munster BC, Aronica E, Zwinderman AH, Eikelenboom P, Cunningham C, Rooij SE: Neuroinflammation in delirium: a postmortem case-control study. Rejuvenation Res 2011; 14: 615-622.
41. Cerejeira J, Nogueira V, Lus P, Vaz-Serra A, Mukaetova-Ladinska EB: The cholinergic system and inflammation: common pathways in delirium pathophysiology. J Am Geriatr Soc 2012; 60: 669-675.
42. Holmes C, Cunningham C, Zotova E, Culliford D, Perry VH: Proinflammatory cytokines, sickness behavior, and Alzheimer disease. Neurology 2011; 77: 212-218.
43. Holmes C, Cunningham C, Zotova E, Woolford J, Dean C, Kerr S, Culliford D, Perry VH: Systemic inflammation and disease progression in Alzheimer disease. Neurology 2009; 73: 768-774.
44. Maclullich AM, Ferguson KJ, Miller T, de Rooij SE, Cunningham C: Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J Psychosom Res 2008; 65: 229-238.
45. Hall RJ, Shenkin SD, Maclullich AM: A systematic literature review of cerebrospinal fluid biomarkers in delirium. Dement Geriatr Cogn Disord 2011; 32: 79-93.
46. Cerejeira J, Batista P, Nogueira V, Vaz-Serra A, Mukaetova-Ladinska EB: The stress response to surgery and postoperative delirium: evidence of hypothalamic pituitary-adrenal axis hyperresponsiveness and decreased suppression of the GH/IGF-1 axis. J Geriatr Psychiatry Neurol 2013; 26: 185-194.
47. Wolf OT: Stress and memory in humans: twelve years of progress? Brain Res 2009; 1293: 142-154.
48. Peng M, Wang YL, Wang CY, Chen C: Dexmedetomidine attenuates lipopolysaccharide-induced proinflammatory response in primary microglia. J Surg Res 2013; 179:e219-e225.