Toward the de novo design of antimicrobial peptides: Lack of correlation between peptide permeabilization of lipid vesicles and antimicrobial, cytolytic, or cytotoxic activity in living cells

Biopolymers - Peptide Science Section

Volumn 102, Issue 1, 2014, Pages 1-6

  He, Jing ^a   Krauson, Aram J ^a   Wimley, William C ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antimicrobial peptide; High throughput screening; Vesicle leakage

Indexed keywords

BACTERIA; CYTOTOXICITY; MAMMALS; MICROORGANISMS; POLYPEPTIDES; THROUGHPUT;

ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; BROAD-SPECTRUM ACTIVITIES; COMBINATORIAL PEPTIDE LIBRARIES; HIGH THROUGHPUT SCREENING; HIGH-THROUGHPUT SCREENS; THERAPEUTIC APPLICATION; VESICLE LEAKAGE;

PEPTIDES;

POLYPEPTIDE ANTIBIOTIC AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; LIPID BILAYER;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CHO CELL LINE; CONSENSUS SEQUENCE; CONTROLLED STUDY; CYTOLYTIC ACTIVITY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; ERYTHROCYTE; ESCHERICHIA COLI; HUMAN; HUMAN CELL; LIPID COMPOSITION; LIPID VESICLE; MAMMAL CELL; MEMBRANE FLUIDITY; NONHUMAN; PEPTIDE LIBRARY; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; ANTIBACTERIAL ACTIVITY; BIOLOGICAL ACTIVITY; DRUG POTENCY; MEMBRANE PERMEABILITY; AMINO ACID SEQUENCE; ANIMAL; BACTERIUM; CELL DEATH; CELL SURVIVAL; CHEMISTRY; CRICETULUS; DRUG EFFECTS; HAMSTER; LIPID BILAYER; MICROBIAL SENSITIVITY TEST; MOLECULAR GENETICS; PERMEABILITY; SYNTHESIS;

MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; CELL DEATH; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DESIGN; LIPID BILAYERS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PERMEABILITY;

EID: 84907858203     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.22281     Document Type: Article

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